Pharmacological correction of formation of connective tissue with mesh hernia repair in experiment

The use of foreign materials in modern herniology, on the one hand, reduces the number of recurrences, and on the other - increases the risk of several complications: profuse exudation and possible infection in the postoperative wound, extensive cicatricial deformation of a zone of operations, persistent pain syndrome and possible reduced fertility in men. In the experiment 30 rats were studied influence of drugs «mesogel®» and «iodopiron» in the course of wound process during operations using mesh explant. Histological methods were evaluated the usefulness of the formation of connective tissue, degree of involvement in cicatricial process is located in the area of operation of tissues and structures. Compared with the control group of animals is set to a relatively low density and fewer collagen fibers. In the control group of animals had a marked proliferative response in the surrounding tissue prosthesis, gross deformity and involvement in the scar process near structures

CLINICAL AND IMMUNOHISTOCHEMICAL STUDIES IN THE DIAGNOSIS OF UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA IN PATIENTS WITH CHOLELITHIASIS

There were examined 132 patients in the age of 29-77 years old. Morphological features of abnormal shape or position of gallbladder were detected at 26.9% of patients with undifferentiated connective tissue dysplasia, and this may contribute to the formation of gallstones

VISCERAL MANIFESTATIONS UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA IN PATIENTS WITH CHOLELITHIASIS

The study included 132 patients with cholelithiasis (108 women and 24 men) aged 29 to 77 years. Mean age of patients 53,9 ± 12,8 years. In 63 (47,7%) patients with cholelithiasis clinical signs undifferentiated connective tissue dysplasia of varying severity. Of these, 34% of patients detected abnormality of the gastrointestinal tract. In 26,9% of patients with cholelithiasis diagnosed NDCTD anomalies identified various shapes and positions of the gallbladder

LONG-TERM RESULTS OF VARIOUS TREATMENT OPTIONS FOR VENTRAL HERNIAS

In modern herniology tension free technic of hernia repair is a leading, thanks mainly to fewer recurrences. However, hernia repair breaks anatomy and functionality of the anterior abdominal wall, which leads to a deterioration in the quality of life of patients. Objective: To analyze the quality of life of patients after hernia repair ventral hernias. Materials and Methods: The analysis of the results of surgical treatment of 199 patients with ventral hernias after hernia repair in 6 months. For the study used questionnaires quality of life using the SF-36 form. Results: characteristics of each operation, positive and negative, are reflected in the indices of physical and mental health of the survey. Conclusions: onlay, inlay methods of hernia repair are characterized by the best indicators of physical health in the late postoperative period. Methods sublayplastics have a greater impact on the health of the patient in the postoperative period. However, mental health indicators surpass a simple hernia repair techniques

CORRECTION OF METABOLIC DISTRESSES IN PATIENTS WITH DIABETIC FOOT SYNDROME WITH RESEARCH OF STRUCTURAL PHENOMENA OF SERUM OF A BLOOD

Introduced in the article the way of correction of metabolic distresses can be utilised in an intensive care surgical ill with a syndrome of diabetic foot. Nature of a way is the recovery normal of frame of serum of a blood for ill with diabetic foot, improvement of processes of microcirculation in tissues and normalization of parameters of exchange processes in an organism during indirect electrochemical oxidation of a blood

Lipid profile in hospitalized patients with COVID-19 depending on the outcome of its acute phase: data from the international registry "Dynamics analysis of comorbidities in SARS-CoV-2 infection survivors"

Aim. To study the lipid profile in hospitalized patients with coronavirus disease 2019 (COVID-19) depending on the outcome of its acute phase according to the AKTIV international registry.Material and methods. The AKTIV registry included men and women over 18 years of age with a diagnosis of COVID-19, who were treated in a hospital. A total of 9364 patients were included in the registry, of which 623 patients were analyzed for levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C) and triglycerides on days 1-2 of hospitalization. The level of high-density lipoprotein cholesterol (HDL-C) was calculated using the Friedewald equation.Results. We found that a decrease in LDL-C level was significantly associated with an unfavorable prognosis for hospitalized patients with COVID-19. This pattern persisted in both univariate and multivariate analyses. LDL-C levels in the final multivariate model had a significant relationship with the prognosis (an increase in the death risk by 1,7 times with a decrease per 1 mmol/l). In addition, we found that the survival of patients with an indicator level of <2,45 mmol/l is significantly worse than in patients with an LDL-C level ≥2,45 mmol/l. All patients with high LDL-C ((≥4,9 mmol/l) survived, while among patients with low LDL-C (<2,45 mmol/l. All patients with high LDL-C ((≥4,9 mmol/l) survived, while among patients with low LDL-C (<1,4 mmol/l), mortality was 13,04%, which was significantly higher than in patients with LDL-C ≥1,4 mmol/l (6,32%, p=0,047).Conclusion. A decrease in LDL-C in the acute period is significantly associated with an unfavorable prognosis for hospitalized patients with COVID-19. Determination of LDL-C can be included in the examination program for patients with COVID-19. However, the predictive value of this parameter requires further study in prospective clinical studies