Constraining the extra heating of the Diffuse Ionized Gas in the Milky Way

The detailed observations of the diffuse ionized gas through the emission lines H$\alpha$, [NII], and [SII] in the Perseus Arm of our Galaxy by the Wisconsin H$\alpha$ Mapper (WHAM)--survey challenge photoionization models. They have to explain the observed rise in the line ratios [NII]/H$\alpha$ and [SII]/H$\alpha$. The models described here consider for the first time the detailed observational geometry toward the Perseus Arm. The models address the vertical variation of the line ratios up to height of 2 kpc above the midplane. The rising trends of the line ratios are matched. The increase in the line ratios is reflected in a rise of the temperature of the gas layer. This is due to the progressive hardening of the radiation going through the gas. However an extra heating above photoionization is needed to explain the absolute values. Two different extra heating rates are investigated which are proportional to $n^0$ and $n^1$. The models show that a combination of both are best to explain the data, where the extra heating independent of density is dominant for z $>$ 0.8 kpc.Comment: accepted for publication in Ap

Correlated charge polarization in a chain of coupled quantum dots

Coherent charge transfer in a linear array of tunnel-coupled quantum dots, electrostatically coupled to external gates, is investigated using the Bethe ansatz for a symmetrically biased Hubbard chain. Charge polarization in this correlated system is shown to proceed via two distinct processes: formation of bound states in the metallic phase, and charge transfer processes corresponding to a superposition of antibound states at opposite ends of the chain in the Mott-insulating phase. The polarizability in the insulating phase of the chain exhibits a universal scaling behavior, while the polarization charge in the metallic phase of the model is shown to be quantized in units of $e/2$.Comment: 9 pages, 3 figures, 1 tabl

Effect of vasopressin 1b receptor blockade on the hypothalamic-pituitary-adrenal response of chronically stressed rats to a heterotypic stressor

Exposure to chronic restraint (CR) modifies the hypothalamic–pituitary–adrenal (HPA) axis response to subsequent acute stressors with adaptation of the response to a homotypic and sensitization of the response to a heterotypic stressor. Since vasopressin (AVP) activity has been reported to change during chronic stress, we investigated whether this was an important factor in HPA facilitation. We therefore tested whether vasopressin 1b receptor (AVPR1B) blockade altered the ACTH and corticosterone response to heterotypic stressors following CR stress. Adult male rats were exposed to CR, single restraint, or were left undisturbed in the home cage. Twenty-four hours after the last restraint, rats were injected with either a AVPR1B antagonist (Org, 30 mg/kg, s.c.) or vehicle (5% mulgofen in saline, 0.2/kg, s.c.) and then exposed to either restraint, lipopolysaccharide (LPS) or white noise. CR resulted in the adaptation of the ACTH and corticosterone response to restraint and this effect was not prevented by pretreatment with Org. Although we found no effect of CR on LPS-induced ACTH and corticosterone secretion, both repeated and single episodes of restraint induced the sensitization of the ACTH, but not corticosterone response to acute noise. Pretreatment with Org reduced the exaggerated ACTH response to noise after both single and repeated exposure to restraint

Physical Conditions in Circumstellar Gas surrounding SN 1987A 12 Years After Outburst

Two-dimensional spectra of Supernova 1987A were obtained on 1998 November 14-15 (4282 days after outburst) with the Space Telescope Imaging Spectrograph (STIS) on board the Hubble Space Telescope (HST). The slit sampled portions of the inner circumstellar ring at the east and west ansae as well as small sections of both the northern and southern outer rings. The temperature and density at these locations are estimated by nebular analysis of [N II], [O III], and [S II] emission line ratios, and with time-dependent photoionization/recombination models. The results from these two methods are mutually consistent. The electron density in the inner ring is ~ 4000 cm-3 for S II, with progressively lower densities for N II and O III. The electron temperatures determined from [N II] and [O III] line ratios are ~11,000 K and \~22,000 K, respectively. These results are consistent with evolutionary trends in the circumstellar gas from similar measurements at earlier epochs. We find that emission lines from the outer rings come from gas of lower density (n_e \la 2000 cm-3) than that which emits the same line in the inner ring. The N/O ratio appears to be the same in all three rings. Our results also suggest that the CNO abundances in the northern outer ring are the same as in the inner ring, contrary to earlier results of Panagia et al. (1996). Physical conditions in the southern outer ring are less certain because of poorer signal-to-noise data. The STIS spectra also reveal a weak Ha emission redshifted by ~100 km s-1 at p.a. 103\arcdeg that coincides with the recently discovered new regions that are brightening (Lawrence et al. 2000). This indicates that the shock interaction in the SE section of the inner ring commenced over a year before it became apparent in HST images.Comment: 25 pages, 6 figures, to appear in December 1, 2000 Astrophysical Journa

Dose-dependent impact of larval Ascaris suum on host body weight in the mouse model

Ascaris lumbricoides and Ascaris suum are important helminth parasites of humans and pigs, respectively. Although it is now well established that the presence of mature adult worms in the host intestine contributes to significant nutritional morbidity, the impact of larval migratory ascariasis is far less well understood. The development of a mouse model to explore susceptibility and resistance to larval ascariasis in the lungs provided an opportunity to observe the impact of larval migration on host growth during the course of infection. Changes in body weight were monitored in two strains of inbred mice, the susceptible C57BL/6j and the resistant CBA/Ca. Groups of mice received one of four doses: 100, 500, 1000 and 3000 fully embryonated A. suum ova. Infected mice underwent post-mortem on days 6, 7 and 8 post-infection. Control mice received a placebo dose of intubation medium and underwent post-mortem on day 7 post-infection. Mice were weighed pre-infection (day 0) and post-infection on the day of post-mortem. At post-mortem, the lungs of each mouse were removed for enumeration of Ascaris larval burdens by means of the modified Baermann method. Control mice of each strain showed an increase in weight from preinfection to post-infection day. Within the C57BL/6j strain, mice infected with higher doses of Ascaris eggs experienced a reduction in body weight; for those given 3000 eggs this was on all three post-mortem days, and for those given 1000, on days 7 and 8. For CBA/Ca mice, only mice receiving the 3000 dose demonstrated a reduction in body weight. These findings suggest that larval migratory ascariasis has a significant negative impact upon host growth and that this is related to infective dose and larval burden

Effect of the glucocorticoid receptor antagonist Org 34850 on fast and delayed feedback of corticosterone release

We investigated the effect of the glucocorticoid receptor (GR) antagonist Org 34850 on fast and delayed inhibition of corticosterone secretion in response to the synthetic glucocorticoid methylprednisolone (MPL). Male rats were implanted with a catheter in the right jugular vein, for blood sampling and MPL administration, and with an s.c. cannula for Org 34850 administration. All experiments were conducted at the diurnal hormonal peak in the late afternoon. Rats were connected to an automated sampling system and blood samples were collected every 5 or 10 min. Org 34850 (10 mg/kg, s.c.) or vehicle (5% mulgofen in saline) was injected at 1630 h; 30 min later, rats received an injection of MPL (500 μg/rat, i.v.) or saline (0.1 ml/rat). We found that an acute administration of MPL rapidly decreased the basal corticosterone secretion and this effect was not prevented by acute pretreatment with Org 34850. However, blockade of GR with Org 34850 prevented delayed inhibition of MPL on corticosterone secretion measured between 4 and 12 h after MPL administration. Our data suggest an involvement of GR in modulating delayed, but not fast, inhibition induced by MPL on basal corticosterone secretion

Coherent Resonant Tunneling Through an Artificial Molecule

Coherent resonant tunneling through an artificial molecule of quantum dots in an inhomogeneous magnetic field is investigated using an extended Hubbard model. Both the multiterminal conductance of an array of quantum dots and the persistent current of a quantum dot molecule embedded in an Aharanov-Bohm ring are calculated. The conductance and persistent current are calculated analytically for the case of a double quantum dot and numerically for larger arrays using a multi-terminal Breit-Wigner type formula, which allows for the explicit inclusion of inelastic processes. Cotunneling corrections to the persistent current are also investigated, and it is shown that the sign of the persistent current on resonance may be used to determine the spin quantum numbers of the ground state and low-lying excited states of an artificial molecule. An inhomogeneous magnetic field is found to strongly suppress transport due to pinning of the spin-density-wave ground state of the system, and giant magnetoresistance is predicted to result from the ferromagnetic transition induced by a uniform external magnetic field.Comment: 23 pages, 12 figure

Disorder and Interaction in 2D: Exact diagonalization study of the Anderson-Hubbard-Mott model

We investigate, by numerically calculating the charge stiffness, the effects of random diagonal disorder and electron-electron interaction on the nature of the ground state in the 2D Hubbard model through the finite size exact diagonalization technique. By comparing with the corresponding 1D Hubbard model results and by using heuristic arguments we conclude that it is \QTR{it}{unlikely} that there is a 2D metal-insulator quantum phase transition although the effect of interaction in some range of parameters is to substantially enhance the non-interacting charge stiffness.Comment: 13 pages, 2 figures Revised version. Accepted for publication in Phys. Rev. Let

Control of quantum interference in molecular junctions: Understanding the origin of Fano and anti- resonances

We investigate within a coarse-grained model the conditions leading to the appearance of Fano resonances or anti-resonances in the conductance spectrum of a generic molecular junction with a side group (T-junction). By introducing a simple graphical representation (parabolic diagram), we can easily visualize the relation between the different electronic parameters determining the regimes where Fano resonances or anti-resonances in the low-energy conductance spectrum can be expected. The results obtained within the coarse-grained model are validated using density-functional based quantum transport calculations in realistic T-shaped molecular junctions.Comment: 5 pages, 5 figure