(In)validity of large N orientifold equivalence

It has been argued that the bosonic sectors of supersymmetric SU(N) Yang-Mills theory, and of QCD with a single fermion in the antisymmetric (or symmetric) tensor representation, are equivalent in the $N\to\infty$ limit. If true, this correspondence can provide useful insight into properties of real QCD (with fundamental representation fermions), such as predictions [with O(1/N) corrections] for the non-perturbative vacuum energy, the chiral condensate, and a variety of other observables. Several papers asserting to have proven this large N ``orientifold equivalence'' have appeared. By considering theories compactified on $R^3 \times S^1$, we show explicitly that this large N equivalence fails for sufficiently small radius, where our analysis is reliable, due to spontaneous symmetry breaking of charge conjugation symmetry in QCD with an antisymmetric (or symmetric) tensor representation fermion. This theory is also chirally symmetric for small radius, unlike super-Yang-Mills. The situation is completely analogous to large-N equivalences based on orbifold projections: simple symmetry realization conditions are both necessary and sufficient for the validity of the large N equivalence. Whether these symmetry realization conditions are satisfied depends on the specific non-perturbative dynamics of the theory under consideration. Unbroken charge conjugation symmetry is necessary for validity of the large N orientifold equivalence. Whether or not this condition is satisfied on $R^4$ (or $R^3 \times S^1$ for sufficiently large radius) is not currently known.Comment: 23 pages, added discussion of P, T symmetry realizatio

Energy barrier in the two-Higgs model

The electroweak model is extended by a second Higgs doublet and a numerical investigation of static, finite energy classical solutions is performed. The results indicate that for a large domain of the parameters of the Higgs potential, the energy barrier between topologically distinct vacua of the Lagrangian is constituted by a bisphaleron.Comment: 19 pages, including 4 eps figures, LaTex format, new results include

Non-perturbative equivalences among large N gauge theories with adjoint and bifundamental matter fields

We prove an equivalence, in the large N limit, between certain U(N) gauge theories containing adjoint representation matter fields and their orbifold projections. Lattice regularization is used to provide a non-perturbative definition of these theories; our proof applies in the strong coupling, large mass phase of the theories. Equivalence is demonstrated by constructing and comparing the loop equations for a parent theory and its orbifold projections. Loop equations for both expectation values of single-trace observables, and for connected correlators of such observables, are considered; hence the demonstrated non-perturbative equivalence applies to the large N limits of both string tensions and particle spectra.Comment: 40 pages, JHEP styl

From Instantons to Sphalerons: Time-Dependent Periodic Solutions of SU(2)-Higgs Theory

We solve numerically for periodic, spherically symmetric, classical solutions of SU(2)-Higgs theory in four-dimensional Euclidean space. In the limit of short periods the solutions approach tiny instanton-anti-instanton superpositions while, for longer periods, the solutions merge with the static sphaleron. A previously predicted bifurcation point, where two branches of periodic solutions meet, appears for Higgs boson masses larger than $3.091 M_W$.Comment: 14 pages, RevTeX with eps figure

Necessary and sufficient conditions for non-perturbative equivalences of large N orbifold gauge theories

Large N coherent state methods are used to study the relation between U(N) gauge theories containing adjoint representation matter fields and their orbifold projections. The classical dynamical systems which reproduce the large N limits of the quantum dynamics in parent and daughter orbifold theories are compared. We demonstrate that the large N dynamics of the parent theory, restricted to the subspace invariant under the orbifold projection symmetry, and the large N dynamics of the daughter theory, restricted to the untwisted sector invariant under "theory space'' permutations, coincide. This implies equality, in the large N limit, between appropriately identified connected correlation functions in parent and daughter theories, provided the orbifold projection symmetry is not spontaneously broken in the parent theory and the theory space permutation symmetry is not spontaneously broken in the daughter. The necessity of these symmetry realization conditions for the validity of the large N equivalence is unsurprising, but demonstrating the sufficiency of these conditions is new. This work extends an earlier proof of non-perturbative large N equivalence which was only valid in the phase of the (lattice regularized) theories continuously connected to large mass and strong coupling.Comment: 21 page, JHEP styl

Center-stabilized Yang-Mills theory: confinement and large NN volume independence

We examine a double trace deformation of SU(N) Yang-Mills theory which, for large $N$ and large volume, is equivalent to unmodified Yang-Mills theory up to $O(1/N^2)$ corrections. In contrast to the unmodified theory, large $N$ volume independence is valid in the deformed theory down to arbitrarily small volumes. The double trace deformation prevents the spontaneous breaking of center symmetry which would otherwise disrupt large $N$ volume independence in small volumes. For small values of $N$, if the theory is formulated on $\R^3 \times S^1$ with a sufficiently small compactification size $L$, then an analytic treatment of the non-perturbative dynamics of the deformed theory is possible. In this regime, we show that the deformed Yang-Mills theory has a mass gap and exhibits linear confinement. Increasing the circumference $L$ or number of colors $N$ decreases the separation of scales on which the analytic treatment relies. However, there are no order parameters which distinguish the small and large radius regimes. Consequently, for small $N$ the deformed theory provides a novel example of a locally four-dimensional pure gauge theory in which one has analytic control over confinement, while for large $N$ it provides a simple fully reduced model for Yang-Mills theory. The construction is easily generalized to QCD and other QCD-like theories.Comment: 29 pages, expanded discussion of multiple compactified dimension

American Geriatrics Society and National Institute on Aging Bench-to-Bedside conference: sensory impairment and cognitive decline in older adults

This article summarizes the presentations and recommendations of the tenth annual American Geriatrics Society and National Institute on Aging Bench‐to‐Bedside research conference, “Sensory Impairment and Cognitive Decline,” on October 2–3, 2017, in Bethesda, Maryland. The risk of impairment in hearing, vision, and other senses increases with age, and almost 15% of individuals aged 70 and older have dementia. As the number of older adults increases, sensory and cognitive impairments will affect a growing proportion of the population. To limit its scope, this conference focused on sensory impairments affecting vision and hearing. Comorbid vision, hearing, and cognitive impairments in older adults are more common than would be expected by chance alone, suggesting that some common mechanisms might affect these neurological systems. This workshop explored the mechanisms and consequences of comorbid vision, hearing, and cognitive impairment in older adults; effects of sensory loss on the aging brain; and bench‐to‐bedside innovations and research opportunities. Presenters and participants identified many research gaps and questions; the top priorities fell into 3 themes: mechanisms, measurement, and interventions. The workshop delineated specific research questions that provide opportunities to improve outcomes in this growing population.Funding was provided by National Institutes of Health (NIH) Grant U13 AG054139-01. Dr. Whitson's efforts and contributions were supported by R01AG043438, R24AG045050, UH2AG056925, and 5P30AG028716. Dr. Lin's effort and contributions were also supported by R01AG055426, R01HL096812, and R33DC015062. (U13 AG054139-01 - National Institutes of Health (NIH); R01AG043438; R24AG045050; UH2AG056925; 5P30AG028716; R01AG055426; R01HL096812; R33DC015062)Accepted manuscrip

Systematic Multi-Domain Alzheimer's Risk Reduction Trial (SMARRT): Study Protocol.

This article describes the protocol for the Systematic Multi-domain Alzheimer's Risk Reduction Trial (SMARRT), a single-blind randomized pilot trial to test a personalized, pragmatic, multi-domain Alzheimer's disease (AD) risk reduction intervention in a US integrated healthcare delivery system. Study participants will be 200 higher-risk older adults (age 70-89 years with subjective cognitive complaints, low normal performance on cognitive screen, and ≥ two modifiable risk factors targeted by our intervention) who will be recruited from selected primary care clinics of Kaiser Permanente Washington, oversampling people with non-white race or Hispanic ethnicity. Study participants will be randomly assigned to a two-year Alzheimer's risk reduction intervention (SMARRT) or a Health Education (HE) control. Randomization will be stratified by clinic, race/ethnicity (non-Hispanic white versus non-white or Hispanic), and age (70-79, 80-89). Participants randomized to the SMARRT group will work with a behavioral coach and nurse to develop a personalized plan related to their risk factors (poorly controlled hypertension, diabetes with evidence of hyper or hypoglycemia, depressive symptoms, poor sleep quality, contraindicated medications, physical inactivity, low cognitive stimulation, social isolation, poor diet, smoking). Participants in the HE control group will be mailed general health education information about these risk factors for AD. The primary outcome is two-year cognitive change on a cognitive test composite score. Secondary outcomes include: 1) improvement in targeted risk factors, 2) individual cognitive domain composite scores, 3) physical performance, 4) functional ability, 5) quality of life, and 6) incidence of mild cognitive impairment, AD, and dementia. Primary and secondary outcomes will be assessed in both groups at baseline and 6, 12, 18, and 24 months

On Axially Symmetric Solutions in the Electroweak Theory

We present the general ansatz, the energy density and the Chern-Simons charge for static axially symmetric configurations in the bosonic sector of the electroweak theory. Containing the sphaleron, the multisphalerons and the sphaleron-antisphaleron pair at finite mixing angle, the ansatz further allows the construction of the sphaleron and multisphaleron barriers and of the bisphalerons at finite mixing angle. We conjecture that further solutions exist.Comment: 17 pages, latex, THU-94/0