Between Choice and Stigma:Identifications of Economically Successful Migrants

In this contribution, we draw on the unusual but interesting comparison between ‘immigrants’ and ‘expats’, with the aim of scrutinizing identity construction and the tensions between stigma and identity of choice against the background of the (reluctant) superdiverse city of Rotterdam. We focus on two types of socioeconomically successful migrants which, despite their similarities in class position, are generally regarded as rather different. First, middle-class migrants and members of the second generation from ‘classic’ migration groups in the Netherlands (with roots in Surinam, Turkey and Morocco, including descendants of former guest workers). Second, expatriates or knowledge workers of various national backgrounds (including American, English, Indian, Chinese) who came to the Netherlands on a temporary basis because of their highly-skilled jobs (or the jobs of their partners, as we also included trailing spouses). We address the questions of how these migrants perceive themselves, how they think that others perceive them, and how discrepancies between these two affect their feelings of belonging in the city of Rotterdam and the Netherlands. Our findings suggest that while both ‘immigrants’ and ‘expatriates’ combine various identities, immigrants have more difficulty to adopt alternative identities (such as ‘cosmopolitan’) than expatriates because of their dominant label as ‘allochtoon’ (non-native Dutch).</p

The dangers of resource myopia in work and organisational psychology: a plea for broadening and integration broadening

In this essay the limitations of the traditional quantitative approach in work and organisational psychology are put forward. It is argued that an extension of the methods, a broadening of the type of problems to be addressed, and a stronger integration with associated disciplines as well as with the application and implementation of the research findings are needed to ensure the usefulness and application of future W&O psychology. It is not suggested that micro-level problems should not be investigated, but it is postulated that W&O psychology should not be deprived of the opportunity to tackle other, and often more relevant, meso-and macro-level issues because we lack appropriate tools for attacking them

Detection of recurrent copy number alterations in the genome: taking among-subject heterogeneity seriously

Se adjunta un fichero pdf con los datos de investigación titulado "Supplementary Material for \Detection of Recurrent Copy Number Alterations in the Genome: taking among-subject heterogeneity seriously"Background: Alterations in the number of copies of genomic DNA that are common or recurrent among diseased individuals are likely to contain disease-critical genes. Unfortunately, defining common or recurrent copy number alteration (CNA) regions remains a challenge. Moreover, the heterogeneous nature of many diseases requires that we search for common or recurrent CNA regions that affect only some subsets of the samples (without knowledge of the regions and subsets affected), but this is neglected by most methods. Results: We have developed two methods to define recurrent CNA regions from aCGH data. Our methods are unique and qualitatively different from existing approaches: they detect regions over both the complete set of arrays and alterations that are common only to some subsets of the samples (i.e., alterations that might characterize previously unknown groups); they use probabilities of alteration as input and return probabilities of being a common region, thus allowing researchers to modify thresholds as needed; the two parameters of the methods have an immediate, straightforward, biological interpretation. Using data from previous studies, we show that we can detect patterns that other methods miss and that researchers can modify, as needed, thresholds of immediate interpretability and develop custom statistics to answer specific research questions. Conclusion: These methods represent a qualitative advance in the location of recurrent CNA regions, highlight the relevance of population heterogeneity for definitions of recurrence, and can facilitate the clustering of samples with respect to patterns of CNA. Ultimately, the methods developed can become important tools in the search for genomic regions harboring disease-critical genesFunding provided by Fundación de Investigación Médica Mutua Madrileña. Publication charges covered by projects CONSOLIDER: CSD2007-00050 of the Spanish Ministry of Science and Innovation and by RTIC COMBIOMED RD07/0067/0014 of the Spanish Health Ministr

A likelihood ratio approach for utilizing case-control data in the clinical classification of rare sequence variants: Application to BRCA1 and BRCA2

A large number of variants identified through clinical genetic testing in disease susceptibility genes are of uncertain significance (VUS). Following the recommendations of the American College of Medical Genetics and Genomics (ACMG) and Association for Molecular Pathology (AMP), the frequency in case-control datasets (PS4 criterion) can inform their interpretation. We present a novel case-control likelihood ratio-based method that incorporates gene-specific age-related penetrance. We demonstrate the utility of this method in the analysis of simulated and real datasets. In the analysis of simulated data, the likelihood ratio method was more powerful compared to other methods. Likelihood ratios were calculated for a case-control dataset of BRCA1 and BRCA2 variants from the Breast Cancer Association Consortium (BCAC) and compared with logistic regression results. A larger number of variants reached evidence in favor of pathogenicity, and a substantial number of variants had evidence against pathogenicity findings that would not have been reached using other case-control analysis methods. Our novel method provides greater power to classify rare variants compared with classical case-control methods. As an initiative from the ENIGMA Analytical Working Group, we provide user-friendly scripts and preformatted Excel calculators for implementation of the method for rare variants in BRCA1, BRCA2, and other high-risk genes with known penetrance