IL-6, IL-12, and IL-23 STAT-Pathway Genetic Risk and Responsiveness of Lymphocytes in Patients with Multiple Sclerosis

Multiple sclerosis (MS) is an immune-mediated demyelinating disease characterized by central nervous system (CNS) lymphocyte infiltration, abundant production of pro-inflammatory cytokines, and inappropriate activation of Th1 and Th17 cells, B cells, and innate immune cells. The etiology of MS is complex, and genetic factors contribute to disease susceptibility. Genome-wide association studies (GWAS) have revealed numerous MS-risk alleles in the IL-6/STAT3, IL-12/STAT4, and IL-23/STAT3-pathways implicated in the differentiation of Th1 and Th17 cells. In this study, we investigated the signaling properties of these pathways in T, B, and NK cells from patients with relapsing-remitting MS (RRMS) and healthy controls, and assessed the genetic contribution to the activity of the pathways. This revealed a great variability in the level of STAT-pathway molecules and STAT activation between the cell types investigated. We also found a strong donor variation in IL-6, IL-12, and IL-23 responsiveness of primed CD4+ T cells. This variation could not be explained by a single MS-risk variant in a pathway component, or by an accumulation of multiple STAT-pathway MS-risk SNPs. The data of this study suggests that other factors in cohesion with the genetic background contribute to the responsiveness of the IL-6/STAT3, IL-12/STAT4, and IL-23/STAT3-pathways

Wildlife in the Digital Anthropocene: examining human-animal relations through surveillance technologies

Digital surveillance technologies enable a range of publics to observe the private lives of wild animals. Publics can now encounter wildlife from their smartphones, home computers, and other digital devices. These technologies generate public-wildlife relations that produce digital intimacy, but also summon wildlife into relations of care, commodification, and control. Via three case studies, this paper examines the biopolitical implications of such technologically mediated human-animal relations, which are becoming increasingly common and complex in the Digital Anthropocene. Each of our case studies involves a different biopolitical rationale deployed by a scientific-managerial regime: (1) clampdown (wild boar); (2) care (golden eagle); and (3) control (moose). Each of these modalities of biopower, however, is entangled with the other, inaugurating complex relations between publics, scientists, and wildlife. We show how digital technologies can predetermine certain representations of wildlife by encouraging particular gazes, which can have negative repercussions for public-wildlife relations in both digital and offline spaces. However, there remains work to be done to understand the positive public-wildlife relations inaugurated by digital mediation. Here, departing from much extant literature on digital human-animal relations, we highlight some of these positive potentials, notably: voice, immediacy, and agency

Broad-band spectrophotometry of the hot Jupiter HAT-P-12b from the near-UV to the near-IR

The detection of trends or gradients in the transmission spectrum of extrasolar planets is possible with observations at very low spectral resolution. Transit measurements of sufficient accuracy using selected broad-band filters allow for an initial characterization of the atmosphere of the planet. We obtained time series photometry of 20 transit events and analyzed them homogeneously, along with eight light curves obtained from the literature. In total, the light curves span a range from 0.35 to 1.25 microns. During two observing seasons over four months each, we monitored the host star to constrain the potential influence of starspots on the derived transit parameters. We rule out the presence of a Rayleigh slope extending over the entire optical wavelength range, a flat spectrum is favored for HAT-P-12b with respect to a cloud-free atmosphere model spectrum. A potential cause of such gray absorption is the presence of a cloud layer at the probed latitudes. Furthermore, in this work we refine the transit parameters, the ephemeris and perform a TTV analysis in which we found no indication for an unseen companion. The host star showed a mild non-periodic variability of up to 1%. However, no stellar rotation period could be detected to high confidence.Comment: 13 pages, 6 figures, Accepted for publication in A&

Om illegal jakt i Fennoskandia

Ett ökat missnöje bland delar av landsbygdsbefolkningen och jägarsamhället gentemot bevarandepolitiken för stora rovdjur har påverkat den sociopolitiskt motiverade illegala jakten på dessa arter. Denna typ av jaktbrott har legat som grund för undersökningen i ett tvärvetenskapligt internationellt samarbetsprojekt lett av forskare vid Sveriges lantbruksuniversitet, vid Ultuna. Efter tre år av djupintervjuer med jägare, en enkätundersökning, jämförelser med andra delar av världen och nära samarbete med forskare i Fennoskandia avslutades projektet 2016. Föreliggande rapport fullbordar resultatförmedlingen och den avslutande diskussionen omkring forskningsresultaten från projektet och ger samtidigt uppslag för framtida forskning. För första gången presenterades hela projektet och dess medlemmar för en publik bestående av praktiker och intressegrupper runt jakt. Rapporten sammanfattar på detta sätt två dagars temadiskussioner i en workshop med 45 representanter från olika samhällssektorer, bland annat jägare- jordbruks- och naturskyddsorganisationer, länsstyrelser, Naturvårdsverket, polis och åklagare som de ser ut i länderna som utgör Fennoskandia: Sverige, Norge, Danmark och Finland. Diskussionerna handlade om social kontroll och illegal jakt, att flytta viltförvaltningen till domstolarna, EUs inflytande och olika plattformar för att förebygga illegal jakt, speciellt på stora rovdjur, som vargar. Rapporten riktar sig till både forskare och praktiker som möter problem med social accepterade, men hemliga och gömda, former av illegal jakt som i sin tur beror av statsapparatens legitimitetskris, misstro mot politik och politiker och som också är en manifestation för landsbygdens motstånd i ett modernt samhälle.The following report marks the dissemination and discussion of the research results and insights for future research produced by this project. Hence, it represents the first time the full research project and its members stand before the public and interest groups. The report synthesizes two days of workshop thematic discussions between 45 participants from societal sectors including hunting and nature conservation NGOs, county administrative boards, Environmental Protection Agencies, law enforcement, environmental attorneys and farming associations as they feature across the Fennoscandian countries: Sweden, Norway, Denmark and Finland. Its discussions center on social control in wildlife crime, the juridification of hunting issues, the influence of the EU and platforms for going forward to mitigate poaching, in particular of large carnivores like the wolf. The report is an essential read for both researchers and practitioners faced with the problem of socially accepted, but secretive and hidden, forms of illegal hunting in response to governmental legitimacy crises, distrust of policy and policy-makers, and as a manifestation of rural resistance in modernity

On illegal killings of wildlife in Fennoscandia

Rising levels of discontent among rural residents and parts of the hunting community toward large carnivore conservation policy has effected a phenomenon of socio-politically motivated illegal killing of these unpopular species. Such wildlife crime formed the investigation of an interdisciplinary and internationally collaborative research project headed by the Swedish University of Agricultural Sciences in Ultuna, Uppsala. Through 3 years of in-depth interview studies with hunters in Sweden, a quantitative survey to hunters, comparative studies in other parts of the world and close collaboration with Fennoscandian researchers and practitioners, this project ran to completion at the end of 2016. The following report marks the dissemination and discussion of the research results and insights for future research produced by this project. Hence, it represents the first time the full research project and its members stand before the public and interest groups. The report synthesizes two days of workshop thematic discussions between 45 participants from societal sectors including hunting and nature conservation NGOs, county administrative boards, Environmental Protection Agencies, law enforcement, environmental attorneys and farming associations as they feature across the Fennoscandian countries: Sweden, Norway, Denmark and Finland. Its discussions center on social control in wildlife crime, the juridification of hunting issues, the influence of the EU and platforms for going forward to mitigate poaching, in particular of large carnivores like the wolf. The report is an essential read for both researchers and practitioners faced with the problem of socially accepted, but secretive and hidden, forms of illegal hunting in response to governmental legitimacy crises, distrust of policy and policy-makers, and as a manifestation of rural resistance in modernity