37 research outputs found
Ferrocene-1-carbaldehyde thiosemicarbazone
The asymmetric unit of the title compound, [Fe(C5H5)(C7H8N3S)], consists of two crystallographically independent molecules, A and B. The cyclopentadienyl (Cp) rings in both molecules adopt an eclipsed conformation and are parallel to each other, forming dihedral angles of 2.5 (3) and 1.1 (3)°, respectively. The mean plane of the semicarbazone group is coplanar with the attached Cp ring in molecule A, whereas it is twisted away in molecule B. In the crystal structure, intermolecular N—H⋯S hydrogen bonds link the molecules into two-dimensional planes parallel to the ab plane. The structure is further consolidated by C—H⋯π interactions
Bis(1-ferrocenylmethylidene-4-phenylthiosemicarbazidato-κ2 N 1,S)zinc(II) monohydrate
In the title compound, [Fe2Zn(C5H5)2(C13H11N3S)2]·H2O, the ZnII ion is in a distorted tetrahedral geometry being coordinated by two thiosemicarbazone ligands via N and S atoms. One of the Cp rings is disordered over two positions with occupancies of 0.55 and 0.45. The dihedral angle between the substituted Cp rings is 56.1 (5)° and the two phenyl rings are orientated at a dihedral angle of 41.7 (4)°. In the crystal structure, intermolecular O—H⋯S, N—H⋯O and C—H⋯N hydrogen bonds link the molecules into chains along the b axis. The structure is further consolidated by O—H⋯π interactions
Ferrocene-1-carbaldehyde 4-ethylthiosemicarbazone
The asymmetric unit of title compound, [Fe(C5H5)(C9H12N3S)], contains two crystallographically independent molecules, A and B. The two cyclopentadienyl (Cp) rings are parallel to each other in both molecules, forming dihedral angles of 2.3 (3) and 1.0 (3)°, respectively, and adopt an eclipsed conformation. The mean plane of the semicarbazone group is twisted slightly away from the attached Cp ring in both molecules, the dihedral angles between the mean plane and the Cp ring being 15.3 (2) and 10.8 (2)°. The ethyl group in molecule A is coplanar with the mean plane of the semicarbazone group [C—N—C—C torsion angle = −175.2 (4)°], whereas it is nearly perpendicular in molecule B [C—N—C—C torsion angle = 84.8 (6)°]. In the crystal structure, intermolecular N—H⋯S hydrogen bonds link the molecules into dimers. These dimers are further linked into chains via intermolecular C—H⋯S hydrogen bonds. The crystal studied was a non-merohedral twin with a refined ratio of the twin components of 0.265 (2):0.735 (2)
Poly[[aquadi-μ3-malonato-hexaphenylditin(IV)] acetone solvate]
The asymmetric unit of the title polymeric complex, {[Sn2=(C6H5)6(C3H2O4)(H2O)]·C3H6O}n, comprises of two Sn cations, one malonate anion and a non-coordinating acetone solvent molecule. Both crystallographically independent Sn cations are five-coordinated by two O and three C atoms in a distorted trigonal-bipyrimidal geometry. One of the Sn cations is bridged by the malonate units, affording polymeric chains which run along [001]. Weak intramolecular C—H⋯π interactions stabilize the molecular structure. In the crystal structure, adjacent chains are interconnected by intermolecular O—H⋯O and C—H⋯O hydrogen bonds into a three-dimensional supramolecular structure. A weak intermolecular C—H⋯π interaction is also observed
Bis(ferrocenecarbaldehyde thiosemicarbazonato-κ2 N 1,S)zinc
In the title compound, [Fe2Zn(C5H5)2(C7H7N3S)2], the Cp rings of each ferrocene residue have a nearly eclipsed conformation. The two thiosemicarbazone ligands each coordinate the Zn atom in a bidentate mode via the N and S atoms, thereby defining a distorted tetrahedral environment. N—H⋯S, N—H⋯N, C—H⋯S and C—H⋯N intra- and intermolecular interactions connect the molecules into a two-dimensional array parallel to (010)
DNA Interactions and Cytotoxicity of the Aryls-Vertexed Zinc(II) Thiosemicarbazone Complex
A new mononuclear zinc complex of N-phenyl-substituted thiophene thiosemicarbazone ligand [Zn(Httsc-N-Ph)2] was synthesized and characterized, and investigated as nuclease mimic. As compared to carboplatin, a much greater activity against HeLa cells is exhibited by [Zn(Httsc-N-Ph)2] which binds to DNA through an intercalation mechanism
Femoral vein pulsatility: a simple tool for venous congestion assessment
Abstract Background Femoral vein Doppler (FVD) is simpler than the VExUS score which is a multimodal scoring system based on combination of IVC diameter, hepatic venous Doppler, portal vein pulsatility and renal vein Doppler, may be useful in assessing right ventricular overload and signs of venous congestion. There is limited data on the relationship between FVD and VExUS score. Results Adult post-cardiac surgery patients were assessed for venous congestion using the VExUS score and FVD. Agreement between VExUS and FVD was studied using Kappa test, sensitivity, specificity, PPV and NPV for VExUS and FVD was calculated keeping CVP as gold standard. In total, 107 patients were enrolled, with a mean age of 55.67 ± 12.76. The accuracy of VExUS and FVD for detecting venous congestion was 80.37 (95% CI of 71.5 to 87.4) and 74.7 (95% CI of 65.4 to 82.6), respectively. The level of agreement between FVD and VExUS was moderate (Kappa value of 0.62, P < 0.001) while the agreement between FVD and CVP was weak (Kappa value of 0.49, P < 0.001). Conclusion FVD has good accuracy for detecting venous congestion and shows moderate agreement with VExUS grading. With potentially easier physical accessibility and a shorter learning curve for novices, it may be a simple and valuable tool for assessing venous congestion
18F-FDG PET/CT as a potential predictor of survival in patient with oesophageal cancer: a preliminary result
Aims: A study was undertaken to investigate the value of pretreatment PET–CT in predicting survival in patients with oesophageal cancer (OC). Methods: Between June 2010 and December 2011, 18 consecutive OC patients median (61.00 ± 12.07 years) with median survival of 7.5 month had a pretreatment PET–CT scan. Staging of the disease was made in accordance to the American Joint Committee on Cancer staging system (7th edition) and grouped as stage I–IIA and stage IIB–IV. Maximum standardized uptake value (SUVmax), size of a primary tumour and the presence of fluorodeoxyglucose (FDG)-avid lymph nodes were evaluated for all patients. Survival was analysed using the Kaplan–Meier product limit method and Cox proportional hazards regression model. Results: PET–CT stages I–IIA and IIB–IV had a 1-year survival of 50% and 25%, respectively. Patient with size of primary tumour (4.5 cm). Multivariate Cox regression analysis showed that SUVmax of >5.5 in the primary tumour [hazard ratio (HR) 23.017; 95% confidence interval, p = 0.038] and the presence of FDG-avid lymph node (HR 1.248; p = 0.028) were strongly predictive of poor overall survival on multivariate analysis. Conclusion: Pretreatment 18F-FDG PET–CT SUVmax of a primary tumour and the presence of FDG-avid lymph nodes independently predict survival in patients with oesophageal carcinoma which may potentially be used as surrogate markers for prognostic and therapeutic purposes
A new thio-Schiff base fluorophore with copper ion sensing, DNA binding and nuclease activity
Copper ion recognition and DNA interaction of a newly synthesized fluorescent Schiff base (HPyETSC) were investigated using UV-vis and fluorescent spectroscopy. Examination using these two techniques revealed that the detection of copper by HPyETSC is highly sensitive and selective, with a detection limit of 0.39 μm and the mode of interaction between HPyETSC and DNA is electrostatic, with a binding constant of 8.97 × 104 M-1. Furthermore, gel electrophoresis studies showed that HPyETSC exhibited nuclease activity through oxidative pathway
HEPATOPROTECTIVE ACTIVITY OF LEAF OF METHANOL EXTRACT OF LAURUS NOBILIS.L AGAINST PARACETAMOL INDUCED HEPATOTOXICITY IN RATS
Objective: The present study was conducted to evaluate the hepatoprotective activity of methanol extract of Laurus nobilis against paracetamol induced liver damage in rats.Materials and Methods: The methanol extract of Laurus nobilis (200 mg/kg & 400 mg/kg) was administered orally to the animals with hepatotoxicity induced by paracetamol (400 mg/kg). Silymarin (25mg/kg) was given as reference standard. All the test drugs were administered orally by suspending in 0.5% Carboxy methyl cellulose solution.Results: Paracetamol has enhanced the levels of ALT, AST, ALP and bilirubin, whereas the group receiving high dose (400 mg/kg body weight) methanol extract of Laurus nobilis was effective in protecting the liver against the injury induced by paracetamol in rats than that of low dose (200mg/kg body weight) treated group. This was evident from a significant reduction in serum enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and bilirubin.Conclusion: It was concluded from the result that the methanol extract of Laurus nobilis acts on the liver as a potent scavenger of free radicals to prevent the toxic effects of paracetamol induced hepatotoxicity in rats.Keywords: Laurus nobilis, ALT, AST, ALP, hepatotoxicity