Evolution of the density parameter in the anisotropic DGP cosmology

Evolution of the density parameter in the anisotropic DGP braneworld model is studied. The role of shear and cross-over scale in the evolution of $\Omega_\rho$ is examined for both the branches of solution in the DGP model. The evolution is modified significantly compared to the FRW model and further it does not depend on the value of $\gamma$ alone. Behaviour of the cosmological density parameter $\Omega_\rho$ is unaltered in the late universe. The study of decceleration parameter shows that the entry of the universe into self accelerating phase is determined by the value of shear. We also obtain an estimate of the shear parameter $\frac{\Sigma}{H_0} \sim 1.68 \times 10^{-10}$, which is in agreement with the constraints obtained in the literature using data.Comment: To apper in Int.J.Mod.Phys.D, 14 pages, 6 figure

Evaluation of bias correction methods for a multivariate drought index: case study of the Upper Jhelum Basin

Bias correction (BC) is often a necessity to improve the applicability of global and regional climate model (GCM and RCM, respectively) outputs to impact assessment studies, which usually depend on multiple potentially dependent variables. To date, various BC methods have been developed which adjust climate variables separately (univariate BC) or jointly (multivariate BC) prior to their application in impact studies (i.e., the component-wise approach). Another possible approach is to first calculate the multivariate hazard index from the original, biased simulations and bias-correct the impact model output or index itself using univariate methods (direct approach). This has the advantage of circumventing the difficulties associated with correcting the inter-variable dependence of climate variables which is not considered by univariate BC methods. Using a multivariate drought index (i.e., standardized precipitation evapotranspiration index – SPEI) as an example, the present study compares different state-of-the-art BC methods (univariate and multivariate) and BC approaches (direct and component-wise) applied to climate model simulations stemming from different experiments at different spatial resolutions (namely Coordinated Regional Climate Downscaling Experiment (CORDEX), CORDEX Coordinated Output for Regional Evaluations (CORDEX-CORE), and 6th Coupled Intercomparison Project (CMIP6)). The BC methods are calibrated and evaluated over the same historical period (1986–2005). The proposed framework is demonstrated as a case study over a transboundary watershed, i.e., the Upper Jhelum Basin (UJB) in the Western Himalayas. Results show that (1) there is some added value of multivariate BC methods over the univariate methods in adjusting the inter-variable relationship; however, comparable performance is found for SPEI indices. (2) The best-performing BC methods exhibit a comparable performance under both approaches with a slightly better performance for the direct approach. (3) The added value of the high-resolution experiments (CORDEX-CORE) compared to their coarser-resolution counterparts (CORDEX) is not apparent in this study.</p

The prevalence of domestic violence among pregnant women in Nigeria: a systematic review.

To identify, appraise, and synthesize research evidence on the prevalence of domestic violence (DV) among pregnant women in Nigeria. We conducted a systematic review of all published studies between April 2004 and June 2016. Comprehensive searches were conducted on electronic databases such as PubMed, CINAHL, Global Health, MEDLINE, PsycINFO, Directory of Open Access Journals, Google Scholar, and electronic libraries of the authors' institution. Identified articles were screened in two stages against the inclusion criteria with titles and abstract screened first followed by full-text screening. Selected articles were assessed using the "guidelines for evaluating prevalence studies," and findings were synthesized narratively. Among 19 studies that met the inclusion criteria, two articles were excluded due to low methodological quality and 17 articles were included in the review. The prevalence of DV during pregnancy in Nigeria ranged between 2.3% and 44.6% with lifetime prevalence rates ranging between 33.1% and 63.2%. Physical, sexual, psychological, and verbal abuses were the most frequent types of DV reported in this review. The most common perpetrators were husbands, as reported in 11 of the 17 studies. Pregnant women between the ages of 20 and 30 years were the most common victims of DV. Our review suggests high prevalence of DV in pregnancy among women in Nigeria and higher lifetime prevalence. However, determining an overall, synthesized accurate prevalence rate of DV within this population based on existing evidence presents a challenge. The findings have important implications for stakeholders such as planners, policy makers, maternity care providers, and researchers in public health and social policy at national, regional, and international levels toward combating the issue. OBJECTIVE METHOD RESULTS CONCLUSIO

Primary and malignant cholangiocytes undergo CD40 mediated Fas dependent Apoptosis, but are insensitive to direct activation with exogenous fas ligand

Introduction Cholangiocarcinoma is a rare malignancy of the biliary tract, the incidence of which is rising, but the pathogenesis of which remains uncertain. No common genetic defects have been described but it is accepted that chronic inflammation is an important contributing factor. We have shown that primary human cholangiocyte and hepatocyte survival is tightly regulated via co-operative interactions between two tumour necrosis family (TNF) receptor family members; CD40 and Fas (CD95). Functional deficiency of CD154, the ligand for CD40, leads to a failure of clearance of biliary tract infections and a predisposition to cholangiocarcinoma implying a direct link between TNF receptor-mediated apoptosis and the development of cholangiocarcinoma. Aims To determine whether malignant cholangiocytes display defects in CD40 mediated apoptosis. By comparing CD40 and Fas-mediated apoptosis and intracellular signalling in primary human cholangiocytes and three cholangiocyte cell lines. Results Primary cholangiocytes and cholangiocyte cell lines were relatively insensitive to direct Fas-mediated killing with exogenous FasL when compared with Jurkat cells, which readily underwent Fas-mediated apoptosis, but were extremely sensitive to CD154 stimulation. The sensitivity of cells to CD40 activation was similar in magnitude in both primary and malignant cells and was STAT-3 and AP-1 dependent in both. Conclusions 1) Both primary and malignant cholangiocytes are relatively resistant to Fas–mediated killing but show exquisite sensitivity to CD154, suggesting that the CD40 pathway is intact and fully functional in both primary and malignant cholangiocytes 2) The relative insensitivity of cholangiocytes to Fas activation demonstrates the importance of CD40 augmentation of Fas dependent death in these cells. Agonistic therapies which target CD40 and associated intracellular signalling pathways may be effective in promoting apoptosis of malignant cholangiocytes

Popular Culture, Radical Egalitarianism, and Formations of Muslim Selfhood in South Asia

In early twentieth century leftist politics on the geographical fringes of South Asia, Islam played a major role. Were activists in these movements leftist despite their understandings of Islam, or because of them? This essay introduces the project represented in the essays of this special section of South Asian History and Culture, as well as the essays that will appear in a complementary section in a subsequent issue this year. The editors of this project reconstruct a conversation on surprising resonances in subaltern sources in Pashto and Bengali of early twentieth-century grassroots indigenous traditions of radical Muslim egalitarianism. What should we make of these resonances? Building on Latin American decolonisation theory in the wake of Subaltern Studies, we introduce a series of articles that together illustrate what Ramon Grosfoguel calls a ‘pluriverse’ of perspectives on the ethical self: some rooted in the local lifeworlds of Bengal and some in the Afghan borderland; all interlinked through a series of ‘middle actors’. In so doing, we excavate some dense but hidden two-way traffic between subaltern worlds of Muslim piety and devotion on two distant ends of South Asia, and all-India, international or cosmopolitan politics. These together helped constitute a surprising amount of what we know as the South Asian left, from what are usually seen as its geographical, social, and especially intellectual peripheries

Brain mapping in cognitive disorders: a multidisciplinary approach to learning the tools and applications of functional neuroimaging

<p>Abstract</p> <p>Background</p> <p>With rapid advances in functional imaging methods, human studies that feature functional neuroimaging techniques are increasing exponentially and have opened a vast arena of new possibilities for understanding brain function and improving the care of patients with cognitive disorders in the clinical setting. There is a growing need for medical centers to offer clinically relevant functional neuroimaging courses that emphasize the multifaceted and multidisciplinary nature of this field. In this paper, we describe the implementation of a functional neuroimaging course focusing on cognitive disorders that might serve as a model for other medical centers. We identify key components of an active learning course design that impact student learning gains in methods and issues pertaining to functional neuroimaging that deserve consideration when optimizing the medical neuroimaging curriculum.</p> <p>Methods</p> <p>Learning gains associated with the course were assessed using polychoric correlation analysis of responses to the SALG (Student Assessment of Learning Gains) instrument.</p> <p>Results</p> <p>Student gains in the functional neuroimaging of cognition as assessed by the SALG instrument were strongly associated with several aspects of the course design.</p> <p>Conclusion</p> <p>Our implementation of a multidisciplinary and active learning functional neuroimaging course produced positive learning outcomes. Inquiry-based learning activities and an online learning environment contributed positively to reported gains. This functional neuroimaging course design may serve as a useful model for other medical centers.</p

Role of proline, K/Na ratio and chlorophyll content in salt tolerance of wheat (Triticum aestivum

Abstract Studies to determine the role of proline, K/Na ratio and chlorophyll contents in salt tolerance of wheat genotypes were conducted in lysimeters using hydroponics technique. Seeds were allowed to germinate under normal condition (1.5 dS m -1 ) and salinity treatment of 12 dS m -1 was imposed after one week of germination. Crop was irrigated at the interval of two weeks or whenever required with 1/4 th Hoagland nutrient solution of respective concentrations. Results clearly indicated that wheat genotypes with higher proline, K/Na ratio and chlorophyll contents had higher grain yield. On the basis of yield reduction, three genotypes viz. Lu-26s, Sarsabz and KTDH were found tolerant. These genotypes also maintained the higher concentration of proline, K/Na ratio and chlorophyll contents under saline conditions

Dynamics in nonlocal linear models in the Friedmann-Robertson-Walker metric

A general class of cosmological models driven by a nonlocal scalar field inspired by the string field theory is studied. Using the fact that the considering linear nonlocal model is equivalent to an infinite number of local models we have found an exact special solution of the nonlocal Friedmann equations. This solution describes a monotonically increasing Universe with the phantom dark energy.Comment: 18 pages, 3 figures, a few misprints in Section 5 have been correcte

Nonclassical Fields and the Nonlinear Interferometer

We demonstrate several new results for the nonlinear interferometer, which emerge from a formalism which describes in an elegant way the output field of the nonlinear interferometer as two-mode entangled coherent states. We clarify the relationship between squeezing and entangled coherent states, since a weak nonlinear evolution produces a squeezed output, while a strong nonlinear evolution produces a two-mode, two-state entangled coherent state. In between these two extremes exist superpositions of two-mode coherent states manifesting varying degrees of entanglement for arbitrary values of the nonlinearity. The cardinality of the basis set of the entangled coherent states is finite when the ratio $\chi / \pi$ is rational, where $\chi$ is the nonlinear strength. We also show that entangled coherent states can be produced from product coherent states via a nonlinear medium without the need for the interferometric configuration. This provides an important experimental simplification in the process of creating entangled coherent states.Comment: 21 pages, 2 figure