37 research outputs found
Type II compactifications on manifolds with SU(2) x SU(2) structure
We study compactifications of type II theories on SU(2) x SU(2) structure
manifolds to six, five and four spacetime dimensions. We use the framework of
generalized geometry to describe the NS-NS sector of such compactifications and
derive the structure of their moduli spaces. We show that in contrast to SU(3)
x SU(3) structure compactifications, there is no dynamical SU(2) x SU(2)
structure interpolating between an SU(2) structure and an identity structure.
Furthermore, we formulate type II compactifications on SU(2) x SU(2) structures
in the context of exceptional generalized geometry which makes the U-duality
group manifest and naturally incorporates the scalar degrees of freedom arising
in the Ramond-Ramond sector. Via this formalism we derive the structure of the
moduli spaces as it is expected from N=4 supergravity.Comment: 69 pages, v2 published versio
Type IIA orientifold compactification on SU(2)-structure manifolds
We investigate the effective theory of type IIA string theory on
six-dimensional orientifold backgrounds with SU(2)-structure. We focus on the
case of orientifolds with O6-planes, for which we compute the bosonic effective
action in the supergravity approximation. For a generic SU(2)-structure
background, we find that the low-energy effective theory is a gauged N=2
supergravity where moduli in both vector and hypermultiplets are charged. Since
all these supergravities descend from a corresponding N=4 background, their
scalar target space is always a quotient of a SU(1,1)/U(1) x
SO(6,n)/SO(6)xSO(n) coset, and is therefore also very constrained.Comment: 31 pages; v2: local report number adde
E7(7) formulation of N=2 backgrounds
In this paper we reformulate N=2 supergravity backgrounds arising in type II
string theory in terms of quantities transforming under the U-duality group
E7(7). In particular we combine the Ramond--Ramond scalar degrees of freedom
together with the O(6,6) pure spinors which govern the Neveu-Schwarz sector by
considering an extended version of generalised geometry. We give
E7(7)-invariant expressions for the Kahler and hyperkahler potentials
describing the moduli space of vector and hypermultiplets, demonstrating that
both correspond to standard E7(7) coset spaces. We also find E7(7) expressions
for the Killing prepotentials defining the scalar potential, and discuss the
equations governing N=1 vacua in this formalism.Comment: 40 pages, final version to appear in JHE
The development of common data elements for a multi-institute prostate cancer tissue bank: The Cooperative Prostate Cancer Tissue Resource (CPCTR) experience
BACKGROUND: The Cooperative Prostate Cancer Tissue Resource (CPCTR) is a consortium of four geographically dispersed institutions that are funded by the U.S. National Cancer Institute (NCI) to provide clinically annotated prostate cancer tissue samples to researchers. To facilitate this effort, it was critical to arrive at agreed upon common data elements (CDEs) that could be used to collect demographic, pathologic, treatment and clinical outcome data. METHODS: The CPCTR investigators convened a CDE curation subcommittee to develop and implement CDEs for the annotation of collected prostate tissues. The draft CDEs were refined and progressively annotated to make them ISO 11179 compliant. The CDEs were implemented in the CPCTR database and tested using software query tools developed by the investigators. RESULTS: By collaborative consensus the CPCTR CDE subcommittee developed 145 data elements to annotate the tissue samples collected. These included for each case: 1) demographic data, 2) clinical history, 3) pathology specimen level elements to describe the staging, grading and other characteristics of individual surgical pathology cases, 4) tissue block level annotation critical to managing a virtual inventory of cases and facilitating case selection, and 5) clinical outcome data including treatment, recurrence and vital status. These elements have been used successfully to respond to over 60 requests by end-users for tissue, including paraffin blocks from cases with 5 to 10 years of follow up, tissue microarrays (TMAs), as well as frozen tissue collected prospectively for genomic profiling and genetic studies. The CPCTR CDEs have been fully implemented in two major tissue banks and have been shared with dozens of other tissue banking efforts. CONCLUSION: The freely available CDEs developed by the CPCTR are robust, based on "best practices" for tissue resources, and are ISO 11179 compliant. The process for CDE development described in this manuscript provides a framework model for other organ sites and has been used as a model for breast and melanoma tissue banking efforts
Moduli Stabilization and Cosmology of Type IIB on SU(2)-Structure Orientifolds
We consider type IIB flux compactifications on six-dimensional
SU(2)-structure manifolds with O5- and O7-planes. These six-dimensional spaces
allow not only for F_3 and H_3 fluxes but also for F_1 and F_5 fluxes. We
derive the four-dimensional N=1 scalar potential for such compactifications and
present one explicit example of a fully stabilized AdS vacuum with large volume
and small string coupling. We then discuss cosmological aspects of these
compactifications and derive several no-go theorems that forbid dS vacua and
slow-roll inflation under certain conditions. We also study concrete examples
of cosets and twisted tori and find that our no-go theorems forbid dS vacua and
slow-roll inflation in all but one of them. For the latter we find a dS
critical point with \epsilon numerically zero. However, the point has two
tachyons and eta-parameter \eta \approx -3.1.Comment: 35 pages + appendices, LaTeX2e; v2: numerical dS extremum added,
typos corrected, references adde
Supersymmetric Vacua in N=2 Supergravity
We use the embedding tensor formalism to analyse maximally symmetric
backgrounds of N=2 gauged supergravities which have the full N=2 supersymmetry.
We state the condition for N=2 vacua and discuss some of their general
properties. We show that if the gauged isometries leave the SU(2) R-symmetry
invariant, then the N=2 vacuum must be Minkowski. This implies that there are
no AdS backgrounds with eight unbroken supercharges in the effective N=2
supergravity of six-dimensional SU(3) x SU(3) structure compactifications of
type II string theory and M-theory. Combined with previous results on N=1
vacua, we show that there exist N=2 supergravities with a given set of gauged
Abelian isometries that have both N=2 and N=1 vacua. We also argue that an
analogue of our analysis holds in five and six spacetime dimensions.Comment: 14 pages, v2: references added, statement on SU(3) x SU(3) structure
compactifications clarified; v3: published version with statement on moduli
space of N=2 AdS vacua correcte