De Soto’s First Headquarters in Florida

Knowing that Hernando de Soto, his expedition, and the places he visited will probably be matters of discussion for years and years, I have not recently ventured any further contributions regarding them. However, challenge of one of my conclusions, the probable site of the Indian town of Ucita where De Soto established his first North American headquarters, has recently been made in a scientifically motivated paper (“The Terra Ceia Site, Manatee County, Florida.” No. 3 of the Publications of the Florida Anthropological Society, by Ripley P. Bullen), and this calls for some comments

De Soto and Terra Cei

In connection with my work as chairman of the De Soto Expedition Commission between 1935 and 1938 I made a study of the documentary and geographical evidence regarding the location of the point where De Soto landed on the Florida coast in 1539 and the position of his first headquarters. While I was assisted to some extent by other members of the Commission, the conclusions reached were more particularly mine and I assume all responsibility for them. They were originally stated in a paper printed in “The Florida Historical Quarterly” (vol. XVI, no. 3; Jan. 1938) and were incorporated later in the “Final Report of the United States De Soto Expedition Commission” (Washington, 1939). The point where the greater part of the Spanish army was landed was believed to be Shaws Point, and the native town where he established his headquarters apparently at the Indian site on Terra Ceia Island

DEVELOPMENT OF A RECORDING SYSTEM TO EMPIRICALLY ANALYSE THE SHOOTING CHARACTERISTICS OF A CLAY PIGEON SHOOTER

There is a dearth of published information with regard to the sport of clay pigeon shooting. The discipline involves the shooter firing a shotgun at a disc of clay, which is released within a known area but with an unknown trajectory. If the shooter hits the target, the clay breaks and the shooter receives instant feedback on the outcome of the shot. However, if the shooter misses the target the situation requires more analysis. The coach would hugely benefit from a method which gives empirical evidence outlining the kinematics of the shot. This project wil first attempt to identify the relavent characteristics i.e. timings within the shot, acceleration/movement of the gun. Once identified, the variability within these characteristics will be evaluated against the shot outcome results from a commercially available shooting simulator (Dryfire, Derby, UK)

At Home in the Autumn: Seasonable Hints for the Woman of the House: a Household Miscellany

Published by the Dublin Catholic Truth Society of Ireland, Veritas House, 7 & 8 Lower Abbey Street, Dublin in 1945.https://arrow.tudublin.ie/irckbooks/1038/thumbnail.jp

Cancer evolution: Darwin and beyond

Clinical and laboratory studies over recent decades have established branched evolution as a feature of cancer. However, while grounded in somatic selection, several lines of evidence suggest a Darwinian model alone is insufficient to fully explain cancer evolution. First, the role of macroevolutionary events in tumour initiation and progression contradicts Darwin's central thesis of gradualism. Whole-genome doubling, chromosomal chromoplexy and chromothripsis represent examples of single catastrophic events which can drive tumour evolution. Second, neutral evolution can play a role in some tumours, indicating that selection is not always driving evolution. Third, increasing appreciation of the role of the ageing soma has led to recent generalised theories of age-dependent carcinogenesis. Here, we review these concepts and others, which collectively argue for a model of cancer evolution which extends beyond Darwin. We also highlight clinical opportunities which can be grasped through targeting cancer vulnerabilities arising from non-Darwinian patterns of evolution

Understanding the impact of immune-mediated selection on lung cancer evolution

Summary Understanding how a tumour evolves and avoids immune recognition is paramount to improving cancer immunotherapy and patient outcome. Here we examine our recent integration of multi-region genomic, transcriptomic, epigenomic, pathology, and clinical data, highlight the need for a systematic examination of immune escape mechanisms, and discuss implications for immunotherapy approaches

The effect of magnesium on the local structure and initial dissolution rate of simplified UK Magnox waste glasses

A series of simplified glasses were prepared to mimic the United Kingdom’'s Magnox radioactive waste glasses and determine the separate effect of the presence of Mg on the glass structure and the initial dissolution rate. These glasses had an alkaline earth (Ca/Mg) content of 6.5 mol% and relative ratios of Si, B and Na similar to 25 wt% waste loaded Magnox waste glass simulant. Each simplified glass had similar macroscopic properties, differing only in Ca/Mg ratio. 25Mg magic angle spinning nuclear magnetic resonance (MASNMR) spectra of the simplified Mg endmember (MgEM) glass (with no Ca) and the full-component simulant glass were similar, consistent with the similar Mg local environments in both glasses. 11B MASNMR spectra of the series of simplified glasses showed a systematic increase in the amount of three-coordinated boron ([3]B) with increasing amounts of Mg. A clear change in the charge balancing of four-coordinated boron ([4]B) by Mg compared with Ca is observed. However, 11B NMR measurements of the leached material showed that the additional [3]B was not preferentially leached from the Mg containing samples. Despite the structural changes in the glass induced by Ca/Mg substitution, initial dissolution rates (r0) remained invariant, within error, with Ca/Mg ratio. This indicates that the poorer aqueous durability of Mg-containing Magnox waste glass measured experimentally in long-term leaching experiments, compared with SON68 glass containing Ca, is not caused by a primary structural effect in the glass.R. Guo acknowledges the EPSRC and the University of Cambridge for an International Doctoral Scholarship. A portion of this work was funded by Radioactive Waste Management Limited (C.T. Brigden, S.W. Swanton and I. Farnan). The UK 850 MHz solid-state NMR Facility used in this research was funded by EPSRC and BBSRC (contract reference PR140003), as well as the University of Warwick including via part funding through Birmingham Science City Advanced Materials Projects 1 and 2 supported by Advantage West Midlands (AWM) and the European Regional Development Fund (ERDF). Collaborative assistance from the 850 MHz Facility Manager (Dinu Iuga, University of Warwick) is acknowledged

deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution

BACKGROUND: Analysis of somatic mutations provides insight into the mutational processes that have shaped the cancer genome, but such analysis currently requires large cohorts. We develop deconstructSigs, which allows the identification of mutational signatures within a single tumor sample. RESULTS: Application of deconstructSigs identifies samples with DNA repair deficiencies and reveals distinct and dynamic mutational processes molding the cancer genome in esophageal adenocarcinoma compared to squamous cell carcinomas. CONCLUSIONS: deconstructSigs confers the ability to define mutational processes driven by environmental exposures, DNA repair abnormalities, and mutagenic processes in individual tumors with implications for precision cancer medicine