DOPRINOSI NEUROKIRURGIJI SAMUELA D. GROSSA

One of the most famous American Surgeons of the early 1800s was Samuel David Gross (1805-1884). His mastery of surgery was immortalized in Thomas Eakins’ 1875 painting of Gross titled The Gross Clinic. Gross was a prolific surgeon and one of his textbooks, a System of Surgery, went through 6 editions. Not known to many is the fact that this book also covered neurosurgical diseases and techniques. Gross was a skilled surgeon and able writer. His textbooks on surgery were well received in his day. Moreover, he should be considered an early pioneer of neurosurgery as his System of Surgery is filled with neurosurgical diagnoses and neurosurgical techniques.Samuel David Gross (1805.–1884.) bio je jedan od najpoznatijih američkih kirurga prvog dijela 19. stoljeća. Njegova kirurška vještina stekla je besmrtnost u Grossovoj slici Thomasa Eakinsa iz 1875. naslovljenoj Grossova klinika (The Gross Clinic). Gross je bio plodan kirurg i jedan je od njegovih udžbenika, Sustav kirurgije (System of Surgery), doživio 6 izdanja. Ono što je malo poznato jest činjenica da je ta knjiga također pokrila neurokirurške bolesti i tehnike. Gross je bio vješt kirurg i sposoban pisac. Njegovi udžbenici o kirurgiji bili su dobro primljeni u njegovo vrijeme. Štoviše, trebao bi se smatrati ranim pionirom neurokirurgije, budući da je njegov Sustav kirurgije ispunjen neurokirurškim dijagnozama i neurokirurškim tehnikama

DOPRINOSI NEUROKIRURGIJI SAMUELA D. GROSSA

One of the most famous American Surgeons of the early 1800s was Samuel David Gross (1805-1884). His mastery of surgery was immortalized in Thomas Eakins’ 1875 painting of Gross titled The Gross Clinic. Gross was a prolific surgeon and one of his textbooks, a System of Surgery, went through 6 editions. Not known to many is the fact that this book also covered neurosurgical diseases and techniques. Gross was a skilled surgeon and able writer. His textbooks on surgery were well received in his day. Moreover, he should be considered an early pioneer of neurosurgery as his System of Surgery is filled with neurosurgical diagnoses and neurosurgical techniques.Samuel David Gross (1805.–1884.) bio je jedan od najpoznatijih američkih kirurga prvog dijela 19. stoljeća. Njegova kirurška vještina stekla je besmrtnost u Grossovoj slici Thomasa Eakinsa iz 1875. naslovljenoj Grossova klinika (The Gross Clinic). Gross je bio plodan kirurg i jedan je od njegovih udžbenika, Sustav kirurgije (System of Surgery), doživio 6 izdanja. Ono što je malo poznato jest činjenica da je ta knjiga također pokrila neurokirurške bolesti i tehnike. Gross je bio vješt kirurg i sposoban pisac. Njegovi udžbenici o kirurgiji bili su dobro primljeni u njegovo vrijeme. Štoviše, trebao bi se smatrati ranim pionirom neurokirurgije, budući da je njegov Sustav kirurgije ispunjen neurokirurškim dijagnozama i neurokirurškim tehnikama

The Current Understanding of MicroRNA\u27s Therapeutic, Diagnostic, and Prognostic Role in Chordomas: A Review of the Literature.

Chordomas are primary low-grade bone tumors derived from the embryonic notochord that make up less than 5% of all osseous malignancies and commonly affect the spine at its vertebral body and at its two ends i.e., skull base and the sacrum. Although histologically defined to be low-grade, chordoma is locally destructive, metastatic, and has a serious recurrence rate, which all contribute to the dismal median survival rate of six years. Its locally destructive nature places the adjacent vital neurovascular structures at risk, making an en-bloc resection a challenge. This tumor is also known to show high resistance to currently available chemoradiotherapy, although the benefit of proton beam therapy for skull base chordoma has been demonstrated. There is an additional need to focus our attention on investigating the molecular biology of this chemoradiotherapy-resistant tumor to develop a more targeted therapy, which has additional diagnostic and prognostic values. In this paper, we discuss the therapeutic, diagnostic, and prognostic role of microRNAs (miRNAs) in chordomas

Severe bilateral atrophy of the spinati muscles in a cadaver

During the routine dissection of a 62-year-old male cadaver, bilateral atrophy of the supra and infraspinatus muscles was observed. The suprascapular nerves, cervical spinal cord and surrounding muscles were found to be normal. We propose that, in the face of normal histology and other normal shoulder girdle muscles and normal nerves, this case represents an instance of Parsonage-Turner syndrome. To our knowledge, this is the first report of bilateral spinati atrophy in a cadaver

Emerging Cellular Therapies for Glioblastoma Multiforme.

Glioblastoma multiforme (GBM) is the most common type of malignant primary brain cancer in adults. It is composed of highly malignant cells that display metastatic and angiogenic characteristics, making it resistant to current first-line chemotherapy with temozolomide, an alkylating agent. Despite many years of research, GBM remains poorly responsive to multiple available therapies, giving GBM patients, who receive the conventional combination of chemoradiotherapies and surgical resection, a dismal prognosis. There is growing evidence that the conventional systemic chemotherapeutic agents for GBM are ineffective in improving the disease progression. We aim to explore the emerging cellular therapies which may play a significant role in treating GBM

The Current Trend of the Translational Research Paradigm.

The translational research paradigm is a process of discovering basic science concepts and applying the knowledge in clinical practice, aiming to improve patient care. The stages involved in the paradigm form a complex network of shared knowledge amongst research collaborators, including patients. This nature of the paradigm allows those involved to work together effectively. However, the translational research paradigm is often overlooked by many scientists, educators, and research institutions. Hence, a large amount of comprehensive and hugely invested research projects fail to make a scientific impact. We aim to outline and describe this paradigm in order to aid in the successful translation of effective research

Unilateral agenesis of the facial artery with compensation by a giant transverse facial artery

During routine dissections carried out in the course of our medical gross anatomy work, an unusual structure was found unilaterally on the left side of an adult male cadaver. Upon investigation, this was determined to be a hugely dilated transverse facial artery. Also noted was the complete absence of the ipsilateral facial artery. To our knowledge, this is the first report of complete agenesis and not simply diminution of the facial artery with compensatory enlargement of the transverse facial artery

Transsylvian selective amygdalohippocampectomy for treatment of medial temporal lobe epilepsy: Surgical technique and operative nuances to avoid complications

Background: A number of different surgical techniques are effective for treatment of drug-resistant medial temporal lobe epilepsy. Of these, transsylvian selective amygdalohippocampectomy (SA), which was originally developed to maximize temporal lobe preservation, is arguably the most technically demanding to perform. Recent studies have suggested that SA may result in better neuropsychological outcomes with similar postoperative seizure control as standard anterior temporal lobectomy, which involves removal of the lateral temporal neocortex. Methods: In this article, the authors describe technical nuances to improve the safety of SA. Results: Wide sylvian fissure opening and use of neuronavigation allows an adequate exposure of the amygdala and hippocampus through a corticotomy within the inferior insular sulcus. Avoidance of rigid retractors and careful manipulation and mobilization of middle cerebral vessels will minimize ischemic complications. Identification of important landmarks during amygdalohippocampectomy, such as the medial edge of the tentorium and the third nerve within the intact arachnoid membranes covering the brainstem, further avoids operator disorientation. Conclusion: SA is a safe technique for resection of medial temporal lobe epileptogenic foci leading to drug-resistant medial temporal lobe epilepsy

Variant Prevertebral Muscle: Unique Cadaveric Findings.

The levator scapulae muscle typically runs from the transverse process of the atlas to the superior angle of the scapula. In this paper, we describe a rare finding identified during a dissection of a male cadaver, wherein a continuation of the right levator scapulae ran past its normal attachment to the C1 transverse process, fusing with the inferior attachment of the rectus capitis lateralis muscle. No variants were found on the opposite side, and the innervation of the levator scapulae muscle variant was typical of that of a normal levator scapulae. We also describe other related variants of the cranial levator scapulae muscle, hypothesize the embryologic origin of our finding, and finally discuss potential clinical relevance of levator scapulae muscle variants