233 research outputs found
Aloysia macrostachya Moldenke
https://thekeep.eiu.edu/herbarium_specimens_byname/18933/thumbnail.jp
Forestiera pubescens Nutt.
https://thekeep.eiu.edu/herbarium_specimens_byname/21087/thumbnail.jp
Forestiera pubescens Nutt.
https://thekeep.eiu.edu/herbarium_specimens_byname/21086/thumbnail.jp
Mutations of the BRAF gene in human cancer
Cancers arise owing to the accumulation of mutations in critical genes that alter normal programmes of cell proliferation, differentiation and death. As the first stage of a systematic genome-wide screen for these genes, we have prioritized for analysis signalling pathways in which at least one gene is mutated in human cancer. The RAS RAF MEK ERK MAP kinase pathway mediates cellular responses to growth signals. RAS is mutated to an oncogenic form in about 15% of human cancer. The three RAF genes code for cytoplasmic serine/threonine kinases that are regulated by binding RAS. Here we report BRAF somatic missense mutations in 66% of malignant melanomas and at lower frequency in a wide range of human cancers. All mutations are within the kinase domain, with a single substitution (V599E) accounting for 80%. Mutated BRAF proteins have elevated kinase activity and are transforming in NIH3T3 cells. Furthermore, RAS function is not required for the growth of cancer cell lines with the V599E mutation. As BRAF is a serine/threonine kinase that is commonly activated by somatic point mutation in human cancer, it may provide new therapeutic opportunities in malignant melanoma
Polyphenols From Cutch Tree ( Acacia catechu Willd.): Normalize In Vitro Oxidative Stress and Exerts Antiproliferative Activity
Analysis and Purification of Bioactive Natural Products: The AnaPurNa Study
Based on a meta-analysis of data mined from almost
2000 publications on bioactive natural products (NPs) from >80 000
pages of 13 different journals published in 1998−1999, 2004−2005,
and 2009−2010, the aim of this systematic review is to provide both a
survey of the status quo and a perspective for analytical methodology
used for isolation and purity assessment of bioactive NPs. The study provides numerical measures of the common means of
sourcing NPs, the chromatographic methodology employed for NP purification, and the role of spectroscopy and purity
assessment in NP characterization. A link is proposed between the observed use of various analytical methodologies, the
challenges posed by the complexity of metabolomes, and the inescapable residual complexity of purified NPs and their biological
assessment. The data provide inspiration for the development of innovative methods for NP analysis as a means of advancing the
role of naturally occurring compounds as a viable source of biologically active agents with relevance for human health and global
benefit
Fatores limitantes ao crescimento do capim-Tanzânia em um sistema agrossilvipastoril com eucalipto, na região dos Cerrados de Minas Gerais
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The annual probability of an aircraft crash on the US Department of Energy reservation in Oak Ridge, Tennessee
Aircraft hazards were evaluated to determine the total annual probability of an aircraft crash occurring at any structure located on the US Department of Energy (DOE) reservation in Oak Ridge, Tennessee. This report documents the use of an accepted methodology for calculating the probability of an aircraft crash as applied to the three Oak Ridge plant sites including the adjoining facilities. Based on the data contained herein, the evaluation concluded that the probability of an aircraft crash occurrence at a single facility is generally considered ``not credible`` as defined in DOE/OR-901. Additionally, reevaluation of probabilities would be necessary if significant changes were made to local air traffic. The probability of an aircraft crash could increase as a result of the opening of any new airport or heliport in the vicinity; a greater volume of air traffic from McGhee Tyson airport in Knoxville, should the airport status change from feeder airport to hub airport; the rerouting of commercial and/or military flights at the McGhee Tyson airport; and finally, a change in direction or the addition of a federal airway. At one time, DOE planned to establish a zone of prohibited airspace over the Y-12 plant; if the plans are enacted in the future, the probability of an aircraft crash at the Y-12 plant could decrease. Pilots since have been voluntarily requested not to fly below 3000 feet over the Y-12 plant. Also, the Federal Aviation Administration plans to reroute air traffic in the spring of 1993 on federal airway V16. However, the section of V16 which traverses the three plant sites and five adjoining facilities will not be altered. If this plan is implemented, the air traffic over the Oak Ridge facilities would not be affected significantly, and the probability of an aircraft crash as determined herein would be unchanged
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