Vehicle for civil helicopter ride quality research

A research aircraft for investigating the factors involved in civil helicopter operations was developed for NASA Langley Research Center. The aircraft is a reconfigured 17000 kg (36000 lb) military transport helicopter. The basic aircraft was reconfigured with advanced acoustic treatment, air-conditioning, and a 16-seat airline cabin. During the spring of 1975, the aircraft was flight tested to measure interior environment characteristics - noise and vibration - and was flown on 60 subjective flight missions with over 600 different subjects. Data flights established noise levels somewhat higher than expected, with a pure tone at 1400 Hz and vertical vibration levels between 0.07g and 0.17g. The noise and vibration levels were documented during subjective flight evaluations as being the primary source of discomfort. The aircraft will be utilized to document in detail the impact of various noise and vibration levels on passenger comfort during typical short-haul missions

Development of a 1000V, 200A, low-loss, fast-switching, gate-assisted turn-off thyristor

Feasibility was demonstrated for a thyristor that blocks 1000V forward and reverse, conducts 200A, and turns on in little more than 2 microsec with only 2A of gate drive. Its features include a turn-off time of 3 microsec achieved with 2A of gate assist current of a few microseconds duration and an energy dissipation of only 12 mJ per pulse for a 20 microsec half sine wave, 200A pulse. Extensive theoretical and experimental study of the electrical behavior of thyristors having a fast turn-off time have significantly improved the understanding of the physics of turning thyristor off. Thyristors of two new designs were fabricated and evaluated. The high speed and low power were achieved by a combination of gate amplification, cathode shunting, and gate-assisted turn-off. Two techniques for making this combination practical are described

Development of a 1000V, 200A, low-loss, fast-switching, gate-assisted turn-off thyristor

The results of a program to develop a fast high power thyristor that can operate in switching circuits at frequencies of 10 to 20 kHz with very low power loss are given. Feasibility was demonstrated for a thyristor that blocks 1000V forward and reverse, conducts 200A, turns on in little more than 2 more microseconds with only 2A of gate drive, turns off in 3 microseconds with 2A of gate assist current and has an energy dissipation of only 12 mJ per pulse for a 20 microsecond half sine wave 200A pulse. Data were generated that clearly showed the tradeoffs that can be made between the turn off time and forward drop. The understanding of this relationship is necessary in the selection of deliverable thyristors with turn off times up to 7 microseconds to give improved efficiency in a series resonant dc to dc inverter application

Soft X-ray Emission from the Spiral Galaxy NGC 1313

The nearby barred spiral galaxy NGC 1313 has been observed with the PSPC instr- ument on board the ROSAT X-ray satellite. Ten individual sources are found. Three sources (X-1, X-2 and X-3 [SN~1978K]) are very bright (~10^40 erg/s) and are unusual in that analogous objects do not exist in our Galaxy. We present an X-ray image of NGC~1313 and \xray spectra for the three bright sources. The emission from the nuclear region (R ~< 2 kpc) is dominated by source X-1, which is located ~1 kpc north of the photometric (and dynamical) center of NGC~1313. Optical, far-infrared and radio images do not indicate the presence of an active galactic nucleus at that position; however, the compact nature of the \xray source (X-1) suggests that it is an accretion-powered object with central mass M >~ 10^3 Msun. Additional emission (L_X ~ 10^39 erg/s) in the nuclear region extends out to ~2.6 kpc and roughly follows the spiral arms. This emission is from 4 sources with luminosity of several x 10^38 erg/s, two of which are consistent with emission from population I sources (e.g., supernova remnants, and hot interstellar gas which has been heated by supernova remnants). The other two sources could be emission from population II sources (e.g., low-mass \xray binaries). The bright sources X-2 and SN~1978K are positioned in the southern disk of NGC~1313. X-2 is variable and has no optical counterpart brighter than 20.8 mag (V-band). It is likely that it is an accretion-powered object in NGC~1313. The type-II supernova SN~1978K (Ryder \etal 1993) has become extra- ordinarily luminous in X-rays $\sim$13 years after optical maximum.Comment: to appear in 10 Jun 1995 ApJ, 30 pgs uuencoded compressed postscript, 25 pgs of figures available upon request from colbert, whole preprint available upon request from Sandy Shrader ([email protected]), hopefully fixed unknown problem with postscript fil

Detection of amplified DNA sequences by reverse chromosome painting using genomic tumor DNA as probe

A modification of reverse chromosome painting was carried out using genomic DNA from tumor cells as a complex probe for chromosomal in situ suppression hybridization to normal metaphase chromsome spreads. Amplified DNA sequences contained in such probes showed specific signals, revealing the normal chromosome positions from which these sequences were derived. As a model system, genomic DNAs were analyzed from three tumor cell lines with amplification units including the proto-oncogene c-myc. The smallest amplification unit was about 90 kb and was present in 16–24 copies; the largest unit was bigger than 600 kb and was present in 16–32 copies. Specific signals that co-localized with a differently labeled c-myc probe on chromosome band 8q24 were obtained with genomic DNA from each cell line. In further experiments, genomic DNA derived from primary tumor material was used in the case of a male patient with glioblastoma multiforme (GBM). Southern blot analysis using an epidermal growth factor receptor gene (EGFR) probe that maps to 7p13 indicated the amplification of sequences from this gene. Using reverse chromosome painting, signals were found both on band 7p13 and bands 12q13–q15. Notably, the signal on 12q13–q15 was consistently stronger. The weaker 7p13 signal showed co-localization with the major signal of the differently labeled EGFR probe. A minor signal of this probe was seen on 12q13, suggesting cross-hybridization to ERB3 sequences homologous to EGFR. The results indicate co-amplification of sequences from bands 12q13–q15, in addition to sequences from band 7p13. Several oncogenes map to 12q13–q15 providing candidate genes for a tumor-associated proto-oncogene amplification. Although the nature of the amplified sequences needs to be clarified, this experiment demonstrates the potential of reverse chromosome painting with genomic tumor DNA for rapidly mapping the normal chromosomal localization of the DNA from which the amplified sequences were derived. In addition, a weaker staining of chromosomes 10 and X was consistently observed indicating that these chromosomes were present in only one copy in the GBM genome. This rapid approach can be used to analyze cases where no metaphase spreads from the tumor material are available. It does not require any preknowledge of amplified sequences and can be applied to screen large numbers of tumors