Functional changes in the primary somatosensory cortex in complex regional pain syndrome (CRPS): A systematic review

The brain plays a key role in CRPS. A widely-studied brain region in pain research is the primary somatosensory cortex (S1), a somatotopic map of our body’s surface which functionally reorganises in pain [1]. Changes in the S1 representation of the CRPS-affected body part have contributed to new CRPS treatments, e.g. graded motor imagery. This systematic review and meta-analysis aimed to determine whether CRPS is associated with: a) a change in the size of the S1 representation of the affected body part; b) altered S1 activity, in terms of activation levels and latency of responses

Body Fluid Cytokine Levels in Mild Cognitive Impairment and Alzheimer’s Disease: a Comparative Overview

This article gives a comprehensive overview of cytokine and other inflammation associated protein levels in plasma, serum and cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). We reviewed 118 research articles published between 1989 and 2013 to compare the reported levels of 66 cytokines and other proteins related to regulation and signaling in inflammation in the blood or CSF obtained from MCI and AD patients. Several cytokines are evidently regulated in (neuro-) inflammatory processes associated with neurodegenerative disorders. Others do not display changes in the blood or CSF during disease progression. However, many reports on cytokine levels in MCI or AD are controversial or inconclusive, particularly those which provide data on frequently investigated cytokines like tumor necrosis factor alpha (TNF-α) or interleukin-6 (IL-6). The levels of several cytokines are possible indicators of neuroinflammation in AD. Some of them might increase steadily during disease progression or temporarily at the time of MCI to AD conversion. Furthermore, elevated body fluid cytokine levels may correlate with an increased risk of conversion from MCI to AD. Yet, research results are conflicting. To overcome interindividual variances and to obtain a more definite description of cytokine regulation and function in neurodegeneration, a high degree of methodical standardization and patients collective characterization, together with longitudinal sampling over years is essential

Numerical simulation of solidification of a casting taking into account fluid flow and heat transfer phenomena. The axisymmetrical problem

In the paper, a mathematical and a numerical model of solidification of a cylindrical shaped casting, which takes into account the process of filling the mould cavity with the molten metal, has been proposed. The feeding of the casting by a riser head during solidification has also been taken into cansideration. Velocity fields were obtained by solving the Navier-Stokes equations and the continuity equation, while thermal fields were obtained by solving the conduction equation containing the convection term. The changes in the thermophysical parameters, with respect to temperature, were taken into consideration. The problem was solved by the finite element method.Symulacja numeryczna krzepnięcia odlewu z uwzględnieniem zjawisk cieplno-przepływowych. Zadanie osiowo-symetryczne. W pracy sformułowano model matematyczny i numeryczny procesu krzepnięcia odlewu o kształcie cylindrycznym z uwzględnieniem procesu wypełniania wnęki formy ciekłym metalem i zasilania odlewu przez nadlew podczas jego krzepnięcia. Uwzględniono wzajemną zależność zjawisk cieplnych i dynamicznych. Pola prędkości otrzymano z równań Naviera-Stokesa i równania ciągłości, natomiast pola temperatury z rozwiązania równania przewodzenia ciepła z członem konwekcyjnym. Uwzględniano zmianę parametrów termofizycznych w funkcji temperatury. Postawione zadanie rozwiązano metodą elementów skończonych

Development of a quadrotor UAV robot for submarine and oceanic scenarios

Toby Clark, Renjie Du, Ryan Harvie, Sebastian Parkitny, Amir Anva

Primary somatosensory cortex function in complex regional pain syndrome: A systematic review and meta-analysis

That complex regional pain syndrome (CRPS) is associated with functional reorganization in the primary somatosensory cortex (S1) is widely accepted and seldom questioned. Despite more than a decade of research, there has been no systematic review of the CRPS literature concerning the changes in S1 function, and therefore the extent of these changes is unclear. Here we conduct a systematic review and meta-analysis to quantify the spatial and temporal aspects of S1 function in CRPS. A comprehensive search strategy identified functional neuroimaging studies of S1 in CRPS. We adhered to a rigorous systematic review protocol when extracting data and appraising risk of bias. Outcomes were grouped into spatial representation; activation levels, including disinhibition; peak latency of activation; and glucose metabolism. Meta-analysis was conducted where possible. Fifteen studies were included, all investigating upper-extremity CRPS. In patients with CRPS, the S1 spatial representation of the affected hand is smaller than that of the unaffected hand and that of non-CRPS controls; however, this evidence comes from only a few studies. There is no difference in activation, disinhibition, or latency of peripherally evoked S1 responses in CRPS. The risk of bias was high across studies, mainly from unclear sampling methods and unblinded analysis of outcomes. Perspective: The evidence for a difference in function of the primary somatosensory cortex in CRPS compared with controls is clouded by high risk of bias and conflicting results, but reduced representation size seems consisten

Primary motor cortex function in complex regional pain syndrome: A systematic review and meta-analysis

Dysfunction in the central nervous system is thought to underlie the movement disorders that commonly occur in complex regional pain syndrome (CRPS), with much of the literature focusing on reorganization of the primary motor cortex (M1). Presumed changes in the M1 representation of the CRPS-affected body part have contributed to new CRPS treatments, which are increasingly being integrated in the clinic. We systematically investigated the evidence for altered M1 function in CRPS. We adhered to rigorous systematic review procedure in our search strategy, risk-of-bias appraisal, and data extraction. Eighteen studies comprising 14 unique data sets were included. The included studies used several neuroimaging techniques, whose outcomes we grouped into M1 cortical excitability, spatial representation, reactivity, and glucose metabolism, and conducted meta-analyses where possible. Risk of bias across studies was high, mainly due to missing data and unblinded assessment of outcomes. No definitive conclusions can be drawn regarding M1 spatial representation, reactivity, or glucose metabolism in CRPS. There is limited evidence for bilateral M1 disinhibition in CRPS of the upper limb