What Does The Korringa Ratio Measure?

We present an analysis of the Korringa ratio in a dirty metal, emphasizing the case where a Stoner enhancement of the uniform susceptibilty is present. We find that the relaxation rates are significantly enhanced by disorder, and that the inverse problem of determining the bare density of states from a study of the change of the Knight shift and relaxation rates with some parameter, such as pressure, has rather constrained solutions, with the disorder playing an important role. Some preliminary applications to the case of chemical substitution in the Rb$_{3-x}$K$_x$C$_{60}$ family of superconductors is presented and some other relevant systems are mentioned.Comment: 849, Piscataway, New Jersey 08855 24 June 199

Positive association of dopamine D2 receptor polymorphism with bipolar affective disorder in a European Multicenter Association Study of Affective Disorders

Convincing evidence for a genetic component in the etiology of affective disorders (AD), including bipolar affective disorder (BPAD) and unipolar affective disorder (UPAD), is supported by traditional and molecular genetic studies. Most arguments lead to the complex inheritance hypothesis, suggesting that the mode of inheritance is probably not Mendelian but most likely oligogenic (or polygenic) and that the contribution of genes could be moderate or weak. The purpose of the present European multicenter study (13 centers) was to test the potential role in BPAD and UPAD of two candidate dopaminergic markers, DRD2 and DRD3, using a case-control association design. The following samples were analyzed for DRD2: 358 BPAD/358 control (C) and 133 UPAD/ 133 C subjects, and for DRD3: 325 BPAD/ 325 C and 136 UPAD/136 C subjects. Patients and controls were individually matched for sex, age ( plus minus five years) and geographical origin. Evidence for significant association between BPAD and DRD2 emerged, with an over-representation of genotype 5-5 (P=0.004) and allele 5 (P=0.002) in BPAD cases compared to controls. No association was found for DRD2 in UPAD, and for DRD3 neither in BPAD or UPAD. Our results suggest that the DRD2 microsatellite may be in linkage disequilibrium with a nearby genetic variant involved in the susceptibility to BPAD. Our large European sample allowed for replicating of some previous reported positive findings obtained in other study populations.Journal ArticleMulticenter StudySCOPUS: ar.jinfo:eu-repo/semantics/publishe