Carnero v. Boston Scientific Corporation: Interpreting the Extraterritorial Effect of the Civil Whistleblower Protection Provision of the Sarbanes-Oxley Act

This Comment argues that, had the First Circuit employed the effects test, the court could have logically reached the conclusion that the Whistleblower Provision of the Sarbanes-Oxley Act should have extraterritorial effect

Titanocene anticancer complexes and their binding mode of action to human serum albumin: a computational study

Due to the pivotal role played by human serum albumin (HSA) in the transport and cytotoxicity of titanocene complexes, a docking study has been performed on a selected set of titanocene complexes to aid in the current understanding of the potential mode of action of these titanocenes upon binding HSA. Analysis of the docking results has revealed potential binding at the known drug binding sites in HSA and has provided some explanation for the specificity and subsequent cytotoxicity of these titanocenes. Additionally, a new alternative binding site for these titanocenes has been postulated

SunDay: a second application of a simultaneous preference reporting methodology

This paper, the second of three publications reporting on a Simultaneous Preference Reporting Methodology (SPRM), describes the collection of data on SunDay in May 1978. Respondents were drawn from among public visitors to SunDay activities on the Boston Common. The authors find among this presumably sophisticated and knowledgeable respondent group that photovoltaic (PV) solar energy is an undifferentiated innovation, that i PV is too new for a broad sample of the public to comprehend and thus to make distinctions about the technology or its application. However, as in a previous application, the Simultaneous Preference Reporting Methodology appears to be an effective technique for collecting data on public preferences.Prepared for the U.S. Dept. of Energy under Contract no. EX-76-A-01-2295, Task order no. 37

Synchrony and conflict: the relationships among eating disordered attitudes, gender role orientation, and dating styles

College students were surveyed to explore the relationship between eating disordered attitudes, gender role, and dating style. Specifically, two theories regarding gender role were examined: femininity theory and discrepancy theory. The premise of femininity theory was supported in that femininetyped individuals were more likely to report eating disordered behaviors. In addition, a new measure of dating attitudes was created to provide an assessment of nontraditional dating attitudes; surprisingly not only did those scoring high on eating disordered behaviors also score low on nontraditional dating attitudes, but so did both feminine and androgynous individuals. The results underscore the complexity of the issues and provide even greater impetus for more fine-tuned studies of gender orientation

GABA-B receptor function in healthy volunteers, a pharmacokinetic and pharmacodynamic study of two doses of baclofen compared to placebo

AIMS AND HYPOTHESIS To assess the subjective and objective effects of baclofen on brain function in healthy volunteers. BACKGROUND Recent evidence suggests baclofen, a γ-aminobutyric acid type B (GABA-B) receptor agonist, reduces alcohol consumption and craving and promotes abstinence in alcoholics. However, characterisation of the GABA-B receptor system in clinical addiction is limited, and it is unclear why some patients require, or tolerate, higher doses to treat alcoholism. This study assesses the effects of baclofen on brain function in healthy volunteers to inform future studies investigating the sensitivity of GABA-B receptors in alcohol addiction. METHODS Eight healthy male volunteers completed a double blind randomised 3-way cross over study, receiving oral placebo (vitamin C 100mg), 10mg and 60mg baclofen. Subjective and objective measurements were taken at baseline (before medication) and at +30mins, 1, 2, 3, 4 and 6 hours after dosing. Objective measures included blood plasma samples, heart rate and blood pressure. Subjective measures included; the Subjective High Assessment Questionnaire (SHAS), visual analogue scales for sleepy, relaxed, tense and alert and a motor coordination task (zig-zag task). Pharmacokinetic data was obtained using liquid chromatography mass-spectrometry (LC-MS) to measure plasma baclofen concentrations. RESULTS 60mg Baclofen showed changes in subjective measures peaking at 2 hours post dosing compared with placebo, including a significant increase (p<0.05) in total SHAS scores with individual items, including feeling ‘drunk or intoxicated’, effects of alcohol and ‘muddled or confused’ particular affected.. Systolic blood pressure was significantly increased (p<0.05) at the 2 hours post 60mg dose. For both 10mg and 60mg baclofen, peak plasma concentration was achieved 60 minutes post dose. Pharmacokinetic data will be presented. There were no significant changes in these measures between 10mg Baclofen and placebo. CONCLUSIONS The objective and subjective measures used in this study are able to differentiate between placebo and 60mg baclofen. These findings will inform further research investigating the sensitivity of GABA-B receptors in alcohol addiction

A simultaneous preference reporting methodology applied to the Nebraska agricultural community

Prepared for the United States Dept. of Energy under Contract no. EX-76-A-01-2295, Task order 37.One of a series of publications which are part of the institutional analysis research conducted under the Department of Energy's Photovoltaic (PV) Program, this paper describes the Simultaneous Preference Reporting Methodology and reports the results of collecting data in conjunction with an agricultural field test of PV in rlead, Nebraska. The authors find that in the Nebraska Agricultural Community, PV is an undifferentiated innovation. They also conclude that the Simultaneous Preference Reporting Methodology is a promising diagnostic and predictive tool regarding the acceptance of institutional innovation

A COMPARATIVE STUDY BETWEEN BLADES AND STUDS IN FOOTBALL BOOTS

The incidence of non-contact injuries in football is high. A significant proportion of the blame is aimed at the footwear worn. Bladed design boots have attracted criticism, with high profile sports teams banning them amid fears of causing knee injury BBC, 2009). This study aimed to biomechanically compare a bladed boot design with a more conventional studded boot design to assess if either boot type produces a greater muscle response and suggest their potential for causing non-contact injury

Correction to: The hidden therapist: evidence for a central role of music in psychedelic therapy.

The article The hidden therapist: evidence for a central role of music in psychedelic therapy, written by Mendel Kaelen, Bruna Giribaldi, Jordan Raine, Lisa Evans, Christopher Timmerman, Natalie Rodriguez, Leor Roseman, Amanda Feilding, David Nutt, Robin Carhart-Harris, was originally published electronically on the publisher's internet portal

Ab initio Study of Misfit Dislocations at the SiC/Si(001) Interface

The high lattice mismatched SiC/Si(001) interface was investigated by means of combined classical and ab initio molecular dynamics. Among the several configurations analyzed, a dislocation network pinned at the interface was found to be the most efficient mechanism for strain relief. A detailed description of the dislocation core is given, and the related electronic properties are discussed for the most stable geometry: we found interface states localized in the gap that may be a source of failure of electronic devices

Barriers to Graduate Student Innovation in Social Media

In 2010, entrepreneurial innovation emerged as the theme for a $125 million fundraising initiative at the University of North Carolina at Chapel Hill. The leaders of the initiative argue that if universities embrace entrepreneurial thinking then these “engines of innovation” are poised to help solve some of the world’s biggest problems. In this paper, I argue that the blueprint for such an engine is far from complete, especially where the role of graduate students is concerned. Over the course of my Master’s program, I tried to launch a venture to build a community-owned “social archive site” for poverty alleviation. This paper is a case study of that entrepreneurial effort and the barriers to innovation I encountered