Global monopole as dual-vacuum solution in Kaluza-Klein spacetime

By application of the duality transformation, which implies interchange of active and passive electric parts of the Riemann curvature (equivalent to interchange of Ricci and Einstein tensors) it is shown that the global monopole solution in the Kaluza-Klein spacetime is dual to the corresponding vacuum solution. Further we also obtain solution dual to flat space which would in general describe a massive global monopole in 4-dimensional Euclidean space and would have massless limit analogus to the 4-dimensional dual-flat solution.Comment: 8 pages, LaTEX versio

Spectrophotometric Studies on Fe(III) Complexes

286-28

TRAVOS: Trust and Reputation in the Context of Inaccurate Information Sources

In many dynamic open systems, agents have to interact with one another to achieve their goals. Here, agents may be self-interested, and when trusted to perform an action for another, may betray that trust by not performing the action as required. In addition, due to the size of such systems, agents will often interact with other agents with which they have little or no past experience. There is therefore a need to develop a model of trust and reputation that will ensure good interactions among software agents in large scale open systems. Against this background, we have developed TRAVOS (Trust and Reputation model for Agent-based Virtual OrganisationS) which models an agent's trust in an interaction partner. Specifically, trust is calculated using probability theory taking account of past interactions between agents, and when there is a lack of personal experience between agents, the model draws upon reputation information gathered from third parties. In this latter case, we pay particular attention to handling the possibility that reputation information may be inaccurate

Synthesis, Characterization and Biological Studies of Mononuclear Copper(II) Complexes with Ciprofloxacin and N, O Donor Ligands

The mixed ligand Cu(II) complexes of ciprofloxacin and N, O donor Schiff bases have been prepared and characterized by physicochemical techniques. In these complexes, ciprofloxacin acts as bidentate deprotonated ligand bound to the metal through the pyridone oxygen and one carboxylate oxygen. The antimicrobial activity of the complexes has been tested on three Gram(− ve) and two Gram(+ ve) microorganisms in terms of minimum inhibitory concentration (MIC) and colony forming unit (CFU). The interaction study of the complexes with Herring Sperm DNA (HS-DNA) has been performed by absorption titration and viscosity measurement. The DNA cleavage activity has been carried out by gel electrophoresis experiment using supercoiled form of pUC19 DNA. Potential cytotoxic effect of complexes has been investigated by brine shrimp lethality assay method. The complexes have been also screened for their enzymatic behaviour in terms of IC50 value

Cytotoxic, Antibacterial, DNA Interaction and Superoxide Dismutase Like Activities of Sparfloxacin Drug Based Copper(II) Complexes with Nitrogen Donor Ligands

The novel neutral mononuclear copper(II) complexes with fluoroquinolone antibacterial drug, sparfloxacin and nitrogen donor heterocyclic ligand have been synthesized and characterized. An antimicrobial efficiency of the complexes has been tested against five different microorganisms and showed diverse biological activity. The interaction of complex with Herring sperm (HS) DNA was investigated using viscosity titration and absorption titration techniques. The results indicate that the complexes bind to DNA by intercalative mode and have rather high DNA-binding constants. DNA cleavage study showed better cleaving ability of the complexes compare to metal salt and standard drug. All the complexes showed good cytotoxic activity with LC50 values ranging from 4.89 to 11.94 μg mL−1. Complexes also exhibit SOD-like activity with their IC50 values ranging from 0.717 to 1.848 μM

DNA Interaction, In Vitro Antimicrobial and SOD-like Activity of Copper(II) Complexes with Norfloxacin and Terpyridines

The novel octahedral copper(II) complexes with the second generation fluoroquinolone, norfloxacin and terpyridine derivatives were prepared and characterized. The antimicrobial efficiency of the complexes were tested on five different microorganisms and showed good biological activity. Viscosity measurement and absorption titration were employed to determine the mode of binding of complexes with DNA whereas the cleavage efficacy of the complexes towards pUC19 DNA was determined by electrophoresis in presence of ethidium bromide. SOD mimic behaviour was actively sought for clinical and mechanistic purposes under a nonenzymatic system (NBT/NADH/PMS), and was found to have good antioxidant activity

Interaction of Drug Based Copper(II) Complexes with Herring Sperm DNA and Their Biological Activities

Square pyramidal Cu(II) complexes with NS donor ligand and ciprofloxacin have been synthesized and characterized using analytical and spectral techniques. The synthesized complexes have been tested for their antimicrobial activity using double dilution technique in terms of minimum inhibitory concentration (MIC) and colony forming unit (CFU). The DNA binding ability of the complexes with Sperm Herring DNA has been performed using absorption titration and viscosity measurement. The nuclease activity of complexes with plasmid DNA (pUC19) has been carried out using agarose gel electrophoresis technique. Synthesized complexes have been tested for their SOD mimic activity using NBT/NADH/PMS system. The cytotoxic properties of metal complexes have been evaluated using brine shrimp lethality bioassay

Copper(II) Complexes with Norfloxacin and Neutral Terpyridines: Cytotoxic, Antibacterial, Superoxide Dismutase and DNA-interaction Approach

Cu(II) complexes of the type [Cu(NFL)(Ln)Cl] (Ln = substituted terpyridines, NFL = norfloxacin) were synthesised and characterized. Antibacterial activity was assayed against selective Gram(+ve) and Gram(-ve) microorganisms using the double dilution technique. The binding behavior of the complexes toward Herring Sperm (HS) DNA was determined using absorption titration and hydrodynamic measurements, whereas the cleavage efficacy of the complexes toward pUC19 DNA was determined by the gel electrophoresis technique. The brine shrimp bioassay was carried out to study the in vitro cytotoxic properties of the synthesized metal complexes. The superoxide dismutase (SOD) like activity of the complexes was measured using an NBT/NADH/PMS system and is expressed in term of the concentration of complex which terminates the formation of formazan by 50% (IC50 value). The IC50 values were observed to be in the range 0.653–1.344 lM