Effect of 6-Month Athletic Training on Motor Abilities in Seven-Year-Old Schoolgirls

The effects of six-month athletic training on improving motor abilities in 7-year-old schoolgirls were assessed. Analysis of the results of 12 motor tests showed significant improvement in the study group (n=38) in comparison with control group (n=140) subjected to conventional physical education classes only. The improvement referred to the variables of aerobic endurance (3-min run), flexibility (forward bow), explosive strength (ball throwing and 20-m run), keeping balance (bench standing), static strength (bent arm hang), and repetitive strength (sit-ups). These are probably adaptive changes brought up by discriminant functions. The varimax factor and discriminative function correlations indicated that all four factors of changes contributed significantly to the explanation of discriminative function. An almost equally high correlation of varimax factors and discriminative function was obtained on the basis of differences in the third factor responsible for changes in the frequency of movements and in the explosive strength of the jump type; in the second factor responsible for changes in coordination with changes in the repetitive strength of the body; and in the fourth factor responsible for changes in the explosive strength of the throw and sprint types with changes and endurance

Successful treatment of polymedicamentous poisoning with metoprolol, diltiazem and cilazapril

Introduction. Poisoning caused by drugs with cardiodepressive effects is an urgent condition in medicine which is associated with high mortality rate regardless of modern therapeutic methods. Accidental or intentional poisoning whit these drugs produces heart activity depression and cardiovascular collapse as consequences. Current therapy for severe poisoning caused by beta-blockers and calcium channel blockers includes both unspecific and specific antidote therapy whit glucagon, as well as application of adrenergic drugs, calcium, phosphodiesterase inhibitors and hyperinsulinemia/euglycemia therapy. However, even whit the application of these drugs, prompt measures of unspecific detoxication therapy and cardiopulmonary reanimation are crucial for survival of patients with severe poisoning. Case report. A 28-year-old female patient was hospitalized for cardiogenic shock and altered state of conscioussnes (Glasgow coma score = 4), caused by acute poisoning with 2 g of metoprolol (Presolol®), 1.8 g of diltiazem (Cortiazem®) and 50 mg of cilazapril (Zobox®). Prolonged cardiopulmonary resuscitation was applied during the first 16 hours of hospitalization, including administration of crystaline solutions (8 L), 17 mg of adrenaline, 4 mg of atropine, 4 mg of glucagone and 1.6 g of dopamine, with electro-stimulation by temporary pacemaker and mechanical ventilation. In a defined time period, normalized state of consciousness was registered, mechanical ventilation was stopped and normal heart activity and hemodynamic stability were accomplished. During hospitalization the patient was treated for mild pneumonia and after ten days, completely recovered, was released and sent to home treatment. Conclusion. Prompt measures of cardiopulmonary resuscitation and multidisciplinary treatment in intensive care units significantly increase the chances of complete recovery of a patient with severe poisoning caused by drugs with cardiodepressive efects

Az első világháború és a lakásbérleti piac, 1914-1938 : Kelet-közép- és délkelet-európai folyamatok tágabb európai kontextusban

The universal tenant-protection schemes and rent control system (RCS) were born out of the huge turmoil triggered by World War I. By the end of the war, the trend towards an ever more elaborated RCS was gaining firm ground; throughout 1920s it was the prevailing model of housing policy on the European continent. The four countries under study followed the above mentioned European trends of increasing state intervention in the housing market, and furthermore, their authorities, representing distinctive Southeast- and East-Central European patterns of administrative modus operandi, applied some of the most intensive forms of housing policies in Europe during the first postwar decade. In the first place, this refers to the practice of requisitioning housing units, which was maintained in these countries, even after it was abolished by the most interventionist Central European countries. According to the innovative 6-level developmental typology, this proved to be the highest level of state intervention in the housing market in interwar Europe (5 out of maximum 6), if the Bolshevik practices (6 out of 6) are to be excluded from the comparison. On the other hand, Southeast European countries managed to effectively return to prewar liberal practices, while this was not accomplished by the most liberal Western European countries. From this perspective, East-Central and Southeast European countries represent confronted patterns of the most liberal and the most interventionist housing policies in Europe in the period under review

The Ethnic Discourse in the Serbian Opposition Press: Demokratija and Srpska reč, 1990–1991

Članak se bavi karakterom i zastupljenošću etničkoga diskursa u srbijanskim opozicijskim glasilima Demokratija i Srpska reč u periodu 1990./1991. Jedno od pitanja koje razmatra ovaj rad odnosi se na preispitivanje teze o nepostojanju relevantne političke alternative tzv. nacionalnom programu Slobodana Miloševića i njegove političke partije u Srbiji u predvečerje raspada Jugoslavije.A statistical analysis of the presence of ethnic discourse (ED) and its subcategory, discourse of ethnic intolerance (DEI), in the party organs Demokratija and Srpska reč shows the indisputably different political character and physiognomy of these two papers. Namely, the average presence of ED in the Srpska reč in the period from June 1990 to June 1991 was four times higher, and the prevalence of DEI ten times higher, than in the Demokratija. In addition to the varying prevalence and character of their ED content, these two organs were fundamentally different as regards the character of their remaining contents. In the Serbian Renewal Movement’s organ, the predominant part of the remaining discourse consisted of revisionist serials and essays dedicated to promoting the Chetnik Movement. These texts made up as much as half of the contents of individual issues of the monthly Srpska reč. Putting together all the pro-Chetnik contents and the ED contents of the Srpska reč, we can conclude that, on average, over 60 percent of each issue’s contents were exceptionally irrational, conservative, and nationalist. On the other hand, after its first few issues, the Demokratija preserved an ethic of responsibility and a critical stance towards the social reality and political situation in the country. After these first few issues, the ethnic discourse in this organ was present only as a precedent and derailment, and was not a commonplace of political rhetoric, unlike in the case of the Srpska reč. The leadership of the Democratic Party certainly played a role in setting up these standards of civil discourse in this organ but, paradoxically, it often also took responsibility for sharpening the ‘national’ line of reasoning within the frame of (forced) political pragmatism. Đinđić’s or Mićunovićev’s ethnic discourse from August 1990 and May 1991 was not supported by a corresponding change in the physiognomy of the paper, which remained predominantly rational, critically oriented, civil, and socially responsible. The analytical verification of facts in this paper certainly supports the thesis of Dubravka Stojanović from 1996 that there was no alternative to this programme in Serbia, at least not within the frame of these two most relevant opposition parties. Furthermore, this paper indicates that, in the summer and autumn of 1990 and in May 1991, the rhetoric of the party leaders of the Serbian Renewal Movement and Democratic Party attempted to be—and often was—more belligerent than Milošević’s. As regards almost all questions of the internal order of Yugoslavia, and especially regarding the status of the autonomy of Kosovo and the regulation of the position of Serbian people outside Serbia, the solutions advocated by the opposition were more radical than the ones advocated by Slobodan Milošević’s regime.

Variability of pomological characteristics of the Šumatovka apple

Variability refers to a process by which differences occur among individuals of the same plant species. However, some characteristics change very little while others, especially quantative ones, change rather quickly and readily even when environmental conditions change slightly. This fact has prompted an investigation aimed to establish the variability of pomological characteristics of the Šumatovka cv. apple tree, a rather old and autochthonous cultivar grown widely throughout Eastern Serbia. Its special characteristic is an ability to grow and bear fruit without any particular care and cultivation, and in conditions of especially severe water deficiency and drought. Šumatovka cv. fruits are small- or medium-sized on the average, the length Measuring 51.3 ± 6.62 mm (CV 12.9%), width 55.5 ± 6.35 mm (CV 11.4%), pedicel lenght 19.5 ± 3.2 mm (CV 16.4%) and fruit mass 66.0 ±20.6 g (CV 31.3%). Total soluble dry matter content of the mesocarp varies between 15.6 and 1.92% (CV 12.31%), total sugars 14.3 ± 4.7% (CV 32.8%) and total sour substances 0.95 ± 0.11% (CV 18.6%). Especially examined were the large-sized Šumatovka fruits measuring 72.0 mm in lenght and width, and 169.4 g in mass

7T functional MRI finds no evidence for distinct functional subregions in the subthalamic nucleus during a speeded decision-making task

The subthalamic nucleus (STN) is a small, subcortical brain structure. It is a target for deep brain stimulation, an invasive treatment that reduces motor symptoms of Parkinson’s disease. Side effects of DBS are commonly explained using the tripartite model of STN organization, which proposes three functionally distinct subregions in the STN specialized in cognitive, limbic, and motor processing. However, evidence for the tripartite model exclusively comes from anatomical studies and functional studies using clinical patients. Here, we provide the first experimental tests of the tripartite model in healthy volunteers using ultra-high field 7 Tesla (T) functional magnetic resonance imaging (fMRI). Thirty-four participants performed a random-dot motion decision-making task with a difficulty manipulation and a choice payoff manipulation aimed to differentially affect cognitive and limbic networks. Moreover, participants responded with their left and right index finger, differentially affecting motor networks. We analysed BOLD signal in three subregions of the STN along the dorsolateral-ventromedial axis, identified using manually delineated high resolution anatomical images and based on a previously published atlas. Using these paradigms, all segments responded equally to the experimental manipulations, and the tasks did not provide evidence for the tripartite model

Effect of 6-Month Athletic Training on Motor Abilities in Seven-Year-Old Schoolgirls

The effects of six-month athletic training on improving motor abilities in 7-year-old schoolgirls were assessed. Analysis of the results of 12 motor tests showed significant improvement in the study group (n=38) in comparison with control group (n=140) subjected to conventional physical education classes only. The improvement referred to the variables of aerobic endurance (3-min run), flexibility (forward bow), explosive strength (ball throwing and 20-m run), keeping balance (bench standing), static strength (bent arm hang), and repetitive strength (sit-ups). These are probably adaptive changes brought up by discriminant functions. The varimax factor and discriminative function correlations indicated that all four factors of changes contributed significantly to the explanation of discriminative function. An almost equally high correlation of varimax factors and discriminative function was obtained on the basis of differences in the third factor responsible for changes in the frequency of movements and in the explosive strength of the jump type; in the second factor responsible for changes in coordination with changes in the repetitive strength of the body; and in the fourth factor responsible for changes in the explosive strength of the throw and sprint types with changes and endurance

The importance of potassium channels in the mechanism of the relaxing effect of pentoxifylline on isolated rat uteri

Background. Pentoxifylline is a methylxanthine derivative that is used to treat peripheral vascular disease. One of the mechanisms of action of pentoxifylline is the vasodilatation of blood vessels. This study examined the effect of increasing pentoxifylline concentrations on the contractility of isolated rat uteri in the presence of a potassium channel antagonist. Methods. The uteri were isolated from virgin Wistar rats (180-220 g) and suspended in an isolated organ bath chamber containing De Jalon's solution and aerated with 95% O2 and 5% CO2. The temperature was maintained at 37єC. Isometric contractions were recorded using an isometric force transducer (Ugo Basile). The preload of the preparation was approximately 1 g. The uteri were allowed to contract spontaneously or in the presence of Ca2+ (0.018 and 0.36 mM) and acetylcholine (ACh) and were treated with pentoxifylline. Results. Pentoxifylline caused concentration-dependent inhibition of spontaneous rhythmic uterine activity and uterine activity caused by calcium Ca2+ (0.018 mM and 0,36 mM). We showed that the inhibitory effects of pentoxifylline depend on the type of muscle contractions activated and that the inhibitory effect is significantly stronger for spontaneous rhythmic activity and forin Ca2 -induced contractions of isolated rat uteri+. The relaxing effect of pentoxifylline depends on the calcium concentration in the medium. Pentoxifylline exerted the weakest relaxant effects on contractions induced by acetylcholine. In contrast to methylene blue, tetraethylammonium, or 4-aminopyridine, glibenclamide did not antagonise the relaxing effect of pentoxifylline on isolated rat uteri. Conclusion. The results obtained suggest that the mechanism of action of pentoxifylline does not lead to the opening of KATP channels. However, the opening of BKCa and voltage-dependent Ca2+ channels had some role, but to varying degrees, in the mechanism of the relaxing effect of pentoxifylline on the spontaneous rhythmic activity and calcium-induced contractions of isolated rat uteri. Our results provide additional confirmation of the dominance of the NO/cGMP signaling pathway in the mechanism of the relaxing effect of pentoxifylline (because the presence of methylene blue significantly antagonised this effect) in relation to the opening of potassium channels, especially KATP channels. These results indicate that pentoxifylline could be a potential tocolytic drug.Cilj. Pentoksifilin, koji se koristi za lečenje perifernih vaskularnih oboljenja, je derivat metilksantina. Jedan od načina delovanja pentoksifilina je prouzrokovanje vazodilatacije krvnih sudova. U ovom radu ispitivali smo efekat rastućih koncentracija pentoksifilina na kontraktilnost izolovanog uterusa pacova, u prisustvu blokatora kalijumskih kanala. Metode. Uterusi, koji su izolovani od neparenih ženki pacova Wistar soja (180-220 g), držani su u kupatilu za izolovane organe na temperaturi od 37oC, u De Jalon-ovom rastvoru kroz koji je propuštana smeša gasova od 95% kiseonika i 5% ugljendioksida. Izometrijske kontrakcije su registrovane korišćenjem izometrijskog transdjusera Ugo Basile, pri opterećenju preparata od 1 g. Ispitivan je efekat pentoksifilina na kontrakcije za vreme spontane ritmičke aktivnosti i u prisustvu kalcijuma, Ca2+ (0.018 and 0.36 mM)) i acetilholina (ACh). Rezultati. Pentoksifilin je prouzrokovao koncentracijski zavisnu inhibiciju spontane ritmičke aktivnosti, kao i fazne aktivnosti prouzrokovane kalcijumom. Inhibicijski efekt pentoksifilina zavisio je od tipa aktivacije glatkog mišića uterusa. On je ispoljio značajno jači relaksirajući efekt na spontanu ritmičku aktivnost i kontrakcije prouzrokovane sa 0.018 mM kalcijuma. Njegov relaksirajući efekt zavisi i od koncentracije Ca2+ u medijumu..Najslabiji relaksirajući efekat pentoksifilina je zabeležen na acetilholinskom tipu aktivacije. Nasuprot metilenskom plavilu, 4-aminopiridinu i tetraetilamonijumu, glibenklamid ne antagonizuje relaksirajući efekat pentoksifilina na izolovanom uterusu pacova. Zaključak. Dobijeni rezultati sugerišu da u mehanizmu relaksantnog delovanja pentoksifilina nije zastupljeno otvaranje ATP kalijumskih kanala. Međutim, otvaranje BKCa i voltažno zavisnih Ca2+ kalijumskih kanala ima izvestan značaj, ali u različitom stepenu, u mehanizmu relaksirajućeg delovanja pentoksifilina na spontanu ritmičku aktivnost i kontrakcije prouzrokovane kalcijumom. Naši rezultati su dodana potvrda o dominaciji NO/cGMP signalinih puteva kojima pentoksifilin prouzrokuje relaksaciju glatkih mišičnih ćelija uterusa (jer metilensko plavilo značajno antagonizuje njegov efekt), u odnosu na otvaranje kalijumskih kanala, posebno ATP zavisnih kalijumskih kanala. Rezultati ukazuju da bi pentoksifilin mogao da bude potencijalni tokolitički lek.nul