Hyperbaric oxygen therapy for late radiation-induced tissue toxicity: Prospectively patient-reported outcome measures in breast cancer patients

__Introduction:__ This study examines patient reported outcome measures of women undergoing hyperbaric oxygen treatment (HBOT) after breast-conserving therapy. __Method:__ Included were 57 women treated with HBOT for late radiation-induced tissue toxicity (LRITT) referred in the period January 2014-December 2015. HBOT consisted of (on average) 47 sessions. In total, 80 min of 100 % O2 was administered under increased pressure of 2.4 ATA. Quality of life was assessed before and after treatment using the European Organization for Research and Treatment of Cancer (EORTC) QLQ-BR23, and a NRS pain score. __Results:__ Fifty-seven women were available for evaluation before and after treatment. Before HBOT, patients had severe complaints of pain in the arm/shoulder (46 %), swollen arm/hand (14 %), difficulty to raise arm or move it sideways (45 %), pain in the area of the affected breast (67 %), swollen area of the affected breast (45 %), oversensitivity of the affected breast (54 %), and skin problems on/in the area of the affected breast (32 %); post HBOT, severe complaints were still experienced in 17, 7, 22, 15, 13, 15, and 11 % of the women, respectively. Differences were all significant. The NRS pain score improved at least 1 point (range 0-10) in 81 % of the patients (p < 0.05). __Conclusion:__ In these breast cancer patients treated with HBOT for LRITT, the patient-reported outcomes were positive and improvements were observed. HBOT was a well-tolerated treatment for LRITT and its side-effects were both minimal and reversible

Autotransplantation of premolars

Autotransplantation is a reliable treatment option for the replacement of missing teeth; however, there is a wide variation in reported survival rates. The purpose of this study was to evaluate the success and survival rate of premolar autotransplantation and to underline the importance of autotransplantation in the treatment of missing teeth. We present the treatment and follow-up of 63 premolar autotransplants in 44 patients. After transplantation under local anaesthesia, radiological and clinical follow-up showed a survival rate of 100%, ie all premolars were still functional. We conclude that autotransplantation of premolars is a reliable treatment method especially for agenesis. It is not difficult to perform and is aesthetically superior and more cost-effective than other treatments, especially when orthodontic alignment is necessary

Autotransplantation of premolars

Autotransplantation is a reliable treatment option for the replacement of missing teeth; however, there is a wide variation in reported survival rates. The purpose of this study was to evaluate the success and survival rate of premolar autotransplantation and to underline the importance of autotransplantation in the treatment of missing teeth. We present the treatment and follow-up of 63 premolar autotransplants in 44 patients. After transplantation under local anaesthesia, radiological and clinical follow-up showed a survival rate of 100%, ie all premolars were still functional. We conclude that autotransplantation of premolars is a reliable treatment method especially for agenesis. It is not difficult to perform and is aesthetically superior and more cost-effective than other treatments, especially when orthodontic alignment is necessary

Neuropathic Pain Due to Iatrogenic Lingual Nerve Lesion: Nerve Grafting to Reduce Otherwise Untreatable Pain

Scientific Assessment and Innovation in Neurosurgical Treatment Strategie

Diffuse sclerosing osteomyelitis and florid osseous dysplasia

The literature on diffuse sclerosing osteomyelitis of the mandible has included at least two groups of lesions: (1) those from which bacterial infectious agents are rarely isolated (chronic-tendoperiostitis); and (2) those from which bacteria are readily isolated (true diffuse sclerosing osteomyelitis). The latter should be distinguished from secondarily infected florid osseous dysplasia. In this article the features of 16 patients with sclerotic jawbone lesions associated with symptoms of infection are analyzed. Eleven patients showed a large area of sclerosis of the mandible that was not restricted to the alveolar process and was surrounding an infectious focus. The histologic pattern revealed a deposition of reactive bone. These lesions are considered to represent true diffuse sclerosing osteomyelitis. The remaining five patients showed sclerotic lesions restricted to the alveolar process in one or more quadrants of the jaws. Apart from inflammation and reactive changes, histologic pattern revealed a fibroblastic stroma with bone and cementum-like structures that are formed by metaplasia. These lesions are considered to represent secondarily infected florid osseous dysplasi

Intra-operative complications in sagittal and vertical ramus osteotomies

In orthognatic surgery of the mandibular ramus, intra-operative complications as a lesion of the inferior alveolar nerve, fractures of the osteotomised segments, incomplete sectioning, malpositioning of segments and haemorrhage may occur. In this report, intra-operative complications in 124 sagittal split osteotomies and 34 vertical ramus osteotomies, carried out in 80 patients, are described. The incidence of intra-operative complications in the sagittal split osteotomies was 25.8%. The complication occurring most frequently was incomplete sectioning (11.2%). This may be avoided by using the modified sagittal split technique. The incidence of complications in the vertical ramus osteotomies was 11.8

Neurosensory disturbances one year after bilateral sagittal split osteotomy of the mandibula performed with separators: A multi-centre prospective study

Development and application of statistical models for medical scientific researc

Accuracy of computer-assisted template-guided autotransplantation of teeth with custom three-dimensional designed/printed surgical tooling: A cadaveric study

Purpose: The aim of the present cadaveric study was to assess the accuracy of computer-assisted template-guided autotransplantation of teeth with custom 3-dimensional (3D) designed/printed surgical tooling. Materials and Methods: Ten partially edentulous human mandibular cadavers were scanned using a cone-beam computed tomography (CBCT) system and an intraoral scanning system. The 3D data of these cadavers were imported to specialized software and used to analyze the region of the recipient sites, and the donor teeth were selected. Subsequently, congruent to the donor teeth, custom surgical tooling and surgical-guided templates were designed and 3D printed. The guided osteotomies were performed and the donor teeth transplanted. To evaluate the planned donor teeth positions compared with the transplanted donor teeth positions, the mandibles were scanned again using the CBCT system, and software matching was applied to measure the accuracy of the procedure. Results: The mean angular deflection of the transplanted donor teeth with the planned donor teeth positions was 5.6 ± 5.4°. Comparing the 3D positions of the shoulders, a mean deviation of 3.15 ± 1.16 mm and a mean apical deviation of 2.61 ± 0.78 mm were found. Conclusions: The described method of computer-assisted template-guided autotransplantation of teeth with custom 3D designed/printed surgical tooling could potentially provide a relatively accurate alternative for the currently available treatment approaches. Further research should focus on improving the accuracy of this technique and evaluating the clinical success and advantages of this method