245 research outputs found

    Findings of a comparison of five filing protocols

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    Filing protocols are essential for the management and dissemination of shared information within computer systems. This is a survey of the current state of the art in filing protocols. Five popular filing protocols were selected and subjected to a rigorous comparison. FTAM, FTP, UNIX rep, XNS Filing, and NFS are compared in the following areas: exported interface, concurrency control, access control, error recovery, and performance. The coverage of background material includes a taxonomy and a brief history of filing protocols

    \u3cem\u3edeElche v. Jacobsen\u3c/em\u3e: Recovering from Community Property for a Separate Tort Judgment

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    This note critically analyzes deElche against the historical background of community property statutes and evaluates its effect on previous case law that subverted community property principles, resulting in injustice to either the victim or the tortfeasor’s spouse. While deElche does not explicitly overrule these cases, it casts doubt on their current vitality. This note also responds to the dissent’s criticisms, and discusses the scope of the deElche decision

    \u3cem\u3edeElche v. Jacobsen\u3c/em\u3e: Recovering from Community Property for a Separate Tort Judgment

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    This note critically analyzes deElche against the historical background of community property statutes and evaluates its effect on previous case law that subverted community property principles, resulting in injustice to either the victim or the tortfeasor’s spouse. While deElche does not explicitly overrule these cases, it casts doubt on their current vitality. This note also responds to the dissent’s criticisms, and discusses the scope of the deElche decision

    Hedgehog Signalling in Androgen Independent Prostate Cancer

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    Objectives: Androgen-deprivation therapy effectively shrinks hormone-naĂŻve prostate cancer, both in the prostate and at sites of distant metastasis. However prolonged androgen deprivation generally results in relapse and androgen-independent tumour growth, which is inevitably fatal. The molecular events that enable prostate cancer cells to proliferate in reduced androgen conditions are poorly understood. Here we investigate the role of Hedgehog signalling in androgen-independent prostate cancer (AIPC). Methods: Activity of the Hedgehog signalling pathway was analysed in cultured prostate cancer cells, and circulating prostate tumour cells were isolated from blood samples of patients with AIPC. Results: AIPC cells were derived through prolonged culture in reduced androgen conditions, modelling hormone therapy in patients, and expressed increased levels of Hedgehog signalling proteins. Exposure of cultured AIPC cells to cyclopamine, which inhibits Hedgehog signalling, resulted in inhibition of cancer cell growth. The expression of the Hedgehog receptor PTCH and the highly prostate cancer-specific gene DD3PCA3 was significantly higher in circulating prostate cancer cells isolated from patients with AIPC compared with samples prepared from normal individuals. There was an association between PTCH and DD3PCA3 expression and the length of androgen-ablation therapy. Conclusions: Our data are consistent with reports implicating overactivity of Hedgehog signalling in prostate cancer and suggest that Hedgehog signalling contributes to the androgen-independent growth of prostate cancer cells. As systemic anti-Hedgehog medicines are developed, the Hedgehog pathway will become a potential new therapeutic target in advanced prostate cancer.Peer reviewedFinal Accepted Versio

    Seasonal and Spatial Dynamics of Alate Aphid Dispersal in Snap Bean Fields in Proximity to Alfalfa and Implications for Virus Management

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    Alfalfa is a source for viruses that may be acquired by aphids and transmitted to snap bean, Phaseolus vulgaris L. Snap bean fields in proximity to alfalfa could have an increased risk of virus infection. Knowledge of the abundance and temporal and spatial dispersal patterns of commonly encountered aphids in commercial snap bean fields, varying in distance from alfalfa, could provide insight into this risk. Alate aphids were monitored using water pan traps in snap bean and alfalfa fields that were adjacent to or >1 km away from each other. The pea aphid, Acyrthosiphon pisum (Harris), was the most common aphid species captured in early-planted snap bean fields in 2002 and 2003 (56 and 23% of total, respectively), whereas the corn leaf aphid, Rhopalosiphum maidis (Fitch), also was common in 2003 (15% of total). In contrast, the yellow clover aphid, Therioaphis trifolii (Monell), and soybean aphid, Aphis glycines Matsumura, were the most abundant species trapped in late-planted snap bean fields in 2002 (77% of total) and 2003 (64% of total), respectively. These species were prevalent in traps in alfalfa as well. The abundance and temporal dispersal patterns of these species in snap beans adjacent to and >1 km away from alfalfa were similar, suggesting that the risk for virus infection may not be affected by proximity to alfalfa. A similar number of alate aphids also were captured along snap bean field edges and field centers, regardless of their proximity to alfalfa. This suggests that the aphids dispersed into snap bean randomly rather than directionally from the field edge. The implication of these results is that separating snap bean fields from alfalfa or using crop borders/barriers are not likely to be successful virus management strategie

    Yield precursor dislocation avalanches in small crystals: the irreversibility transition

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    The transition from elastic to plastic deformation in crystalline metals shares history dependence and scale-invariant avalanche signature with other non-equilibrium systems under external loading: dilute colloidal suspensions, plastically-deformed amorphous solids, granular materials, and dislocation-based simulations of crystals. These other systems exhibit transitions with clear analogies to work hardening and yield stress, with many typically undergoing purely elastic behavior only after 'training' through repeated cyclic loading; studies in these other systems show a power law scaling of the hysteresis loop extent and of the training time as the peak load approaches a so-called reversible-irreversible transition (RIT). We discover here that deformation of small crystals shares these key characteristics: yielding and hysteresis in uniaxial compression experiments of single-crystalline Cu nano- and micro-pillars decay under repeated cyclic loading. The amplitude and decay time of the yield precursor avalanches diverge as the peak stress approaches failure stress for each pillar, with a power law scaling virtually equivalent to RITs in other nonequilibrium systems.Comment: 5 pages, 3 figure

    Circuit Quantum Electrodynamics with a Spin Qubit

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    Circuit quantum electrodynamics allows spatially separated superconducting qubits to interact via a "quantum bus", enabling two-qubit entanglement and the implementation of simple quantum algorithms. We combine the circuit quantum electrodynamics architecture with spin qubits by coupling an InAs nanowire double quantum dot to a superconducting cavity. We drive single spin rotations using electric dipole spin resonance and demonstrate that photons trapped in the cavity are sensitive to single spin dynamics. The hybrid quantum system allows measurements of the spin lifetime and the observation of coherent spin rotations. Our results demonstrate that a spin-cavity coupling strength of 1 MHz is feasible.Comment: Related papers at http://pettagroup.princeton.edu

    Yield precursor dislocation avalanches in small crystals: the irreversibility transition

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    The transition from elastic to plastic deformation in crystalline metals shares history dependence and scale-invariant avalanche signature with other nonequilibrium systems under external loading such as colloidal suspensions. These other systems exhibit transitions with clear analogies to work hardening and yield stress, with many typically undergoing purely elastic behavior only after “training” through repeated cyclic loading; studies in these other systems show a power-law scaling of the hysteresis loop extent and of the training time as the peak load approaches a so-called reversible-to-irreversible transition (RIT). We discover here that deformation of small crystals shares these key characteristics: yielding and hysteresis in uniaxial compression experiments of single-crystalline Cu nano- and micropillars decay under repeated cyclic loading. The amplitude and decay time of the yield precursor avalanches diverge as the peak stress approaches failure stress for each pillar, with a power-law scaling virtually equivalent to RITs in other nonequilibrium systems
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