267 research outputs found
A passively adaptive screwdriver: a novel concept for controlling off-diagonal stiffness
A concept for an automated screw driving mechanism is presented. The proposed mechanism has a self-adjusting axial stiffness that depends on the torsional resistance against screwing. It delivers a greater axial thrust when the torsional resistance is greater, for example, towards the final stage of a screwing operation
The barrier method as a new tool to assist in career selection: covert observational study
Objective To determine if senior doctors’ parking habits and skills are associated with clinical specialty and, if so, whether observation of junior doctors’ parking could provide guidance in choice of specialty
Optimising medicines use in older adults with intellectual disability who have epilepsy: challenges and perspectives.
BBC Charter Review, BBC Audience Council Northern Ireland Submission to the BBC Trust, December 2015
BBC Audience Council Northern Ireland Advice to the BBC Trust Service Review of Nations’ Radio and News and Current Affairs
BBC Trust Provisional Conclusions on BBC proposals for BBC Three, Audience Council Northern Ireland Advice to the Trust, September 2015
A Rare Myelin Protein Zero (MPZ) Variant Alters Enhancer Activity In Vitro and In Vivo
expression. variants. that resides within a previously described SOX10 binding site is associated with decreased enhancer activity, and alters binding of nuclear proteins. Additionally, the genomic segment harboring this variant directs tissue-relevant reporter gene expression in zebrafish. variant within a cis-acting transcriptional regulatory element. While we were unable to implicate this variant in disease onset, our data suggests that similar non-coding sequences should be screened for mutations in patients with neurological disease. Furthermore, our multi-faceted approach for examining the functional significance of non-coding variants can be readily generalized to study other loci important for myelin structure and function
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