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    The relationship between SNPS in the genes of TLR signal transduction pathway downstream elements and rheumatoid arthritis susceptibility

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    Toll-like receptors (TLRs) play an important role in the induction and regulation of the innate immune system or adaptive immune responses. Genetic variations within human TLRs have been reported to be associated with rheumatoid arthritis (RA). This study was conducted to investigate correlation between SNP of downstream mononucleotide in signal transduction of Toll-like receptors and predisposing genes of RA. There was obviously correlative between single nucleotide polymorphism and predisposing genes of RA. G-type of IL-1RAP rs766442 may be protecting genes of RA, while T-type alleles of IL-6R rs11265618 and IL-1RAP rs766442 may be susceptible genes of RA. In conclusion, the studies on the nucleis acid polymorphism in TLRs signal pathway contribute to disclose genes’ influence on the attack mechanism of RA, early diagnosis and treatment of RA.Π’ΠΎΠ»Π»-ΠΏΠΎΠ΄ΠΎΠ±Π½Ρ‹Π΅ Ρ€Π΅Ρ†Π΅ΠΏΡ‚ΠΎΡ€Ρ‹ (TLRs) ΠΈΠ³Ρ€Π°ΡŽΡ‚ Π²Π°ΠΆΠ½ΡƒΡŽ Ρ€ΠΎΠ»ΡŒ Π² ΠΈΠ½Π΄ΡƒΠΊΡ†ΠΈΠΈ ΠΈ рСгуляции Π²Ρ€ΠΎΠΆΠ΄Π΅Π½Π½ΠΎΠΉ ΠΈΠΌΠΌΡƒΠ½Π½ΠΎΠΉ систСмы ΠΈΠ»ΠΈ Π°Π΄Π°ΠΏΡ‚ΠΈΠ²Π½Ρ‹Ρ… ΠΈΠΌΠΌΡƒΠ½Π½Ρ‹Ρ… ΠΎΡ‚Π²Π΅Ρ‚Π°Ρ…. Показано, Ρ‡Ρ‚ΠΎ Ρ‡Ρ‚ΠΎ гСнСтичСская ΠΈΠ·ΠΌΠ΅Π½Ρ‡ΠΈΠ²ΠΎΡΡ‚ΡŒ TLRs Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ° связана с Ρ€Π΅Π²ΠΌΠ°Ρ‚ΠΎΠΈΠ΄Π½Ρ‹ΠΌ Π°Ρ€Ρ‚Ρ€ΠΈΡ‚ΠΎΠΌ (РА). ЦСлью настоящСй Ρ€Π°Π±ΠΎΡ‚Ρ‹ Π±Ρ‹Π»ΠΎ ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΠ΅ коррСляций ΠΌΠ΅ΠΆΠ΄Ρƒ ΠΎΠ΄Π½ΠΎΠ½ΡƒΠΊΠ»Π΅ΠΎΡ‚ΠΈΠ΄Π½Ρ‹ΠΌ ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„ΠΈΠ·ΠΌΠΎΠΌ Π² сигнальной трансдукции TLRs ΠΈ Π³Π΅Π½Π°ΠΌΠΈ прСдрасполоТСнности ΠΊ РА. G-Ρ‚ΠΈΠΏ IL-1RAP rs766442 ΠΌΠΎΠ³ΡƒΡ‚ Π±Ρ‹Ρ‚ΡŒ Π³Π΅Π½Π°ΠΌΠΈ, ΠΏΡ€Π΅Π΄ΠΎΡ…Ρ€Π°Π½ΡΡŽΡ‰ΠΈΠΌΠΈ ΠΎΡ‚ РА, Π² Ρ‚ΠΎ врСмя ΠΊΠ°ΠΊ Π°Π»Π»Π΅Π»ΠΈ T-Ρ‚ΠΈΠΏΠ° IL-6R rs11265618 ΠΈ IL-1RAP rs766442 ΠΌΠΎΠ³ΡƒΡ‚ Π±Ρ‹Ρ‚ΡŒ Π³Π΅Π½Π°ΠΌΠΈ Ρ‡ΡƒΠ²ΡΡ‚Π²ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ ΠΊ РА. Π˜Π·ΡƒΡ‡Π΅Π½ΠΈΠ΅ ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„ΠΈΠ·ΠΌΠ° Π½ΡƒΠΊΠ»Π΅ΠΈΠ½ΠΎΠ²Ρ‹Ρ… кислот Π² сигнальном ΠΏΡƒΡ‚ΠΈ TLRs ΠΌΠΎΠΆΠ΅Ρ‚ внСсти Π²ΠΊΠ»Π°Π΄ Π² выявлСниС участия Π³Π΅Π½ΠΎΠ² Π² ΠΌΠ΅Ρ…Π°Π½ΠΈΠ·ΠΌΠ°Ρ… приступов РА, Ρ€Π°Π½Π½ΡŽΡŽ диагностику ΠΈ Π»Π΅Ρ‡Π΅Π½ΠΈΠ΅ РА.The study was supported by Shandong Province young scientist in incentive fund (Grant β„– 2006BS03018) and National Natural Science Foundation of China (Grant β„– 30801025)
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