3,982 research outputs found
Recommended from our members
Characteristics of successful interventions to reduce turnover and increase retention of early career nurses: a systematic review
Background
nurse shortages have been identified as central to workforce issues in healthcare systems globally and although interventions to increase the nursing workforce have been implemented, nurses leaving their roles, particularly in the first year after qualification, present a significant barrier to building the nurse workforce.
Objective
to evaluate the characteristics of successful interventions to promote retention and reduce turnover of early career nurses.
Design
this is a systematic review
Data sources
Online databases including Academic Search Complete, Medline, Health Policy reference Centre, EMBASE, Psychinfo, CINAHL and the Cochran Library were searched to identify relevant publications in English published between 2001 and April 2018. Studies included evaluated an intervention to increase retention or reduce turnover and used turnover or retention figures as a measure.
Review methods
The review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Studies were quality-assessed using the Joanna Briggs Institute Critical Appraisal tools for Quasi Experimental and Randomised Controlled Trials. Retention/turnover data were used to guide the comparison between studies and appropriate measures of central tendency and dispersion were calculated and presented, based on the normality of the data.
Results
A total of 11, 656 papers were identified, of which 53 were eligible studies. A wide variety of interventions and components within those interventions were identified to improve nurse retention. Promising interventions appear to be either internship/residency programmes or orientation/transition to practice programmes, lasting between 27-52 weeks, with a teaching and preceptor and mentor component.
Conclusions
Methodological issues impacted on the extent to which conclusions could be drawn, even though a large number of studies were identified. Future research should focus on standardising the reporting of interventions and outcome measures used to evaluate these interventions and carrying out further research with rigorous methodology. Clinical practice areas are recommended to assess their current interventions against the identified criteria to guide development of their effectiveness. Evaluations of cost-effectiveness are considered an important next step to maximise return on investment
High Resolution Millimeter-Wave Mapping of Linearly Polarized Dust Emission: Magnetic Field Structure in Orion
We present 1.3 and 3.3 mm polarization maps of Orion-KL obtained with the
BIMA array at approximately 4 arcsec resolution. Thermal emission from
magnetically aligned dust grains produces the polarization. Along the Orion
``ridge'' the polarization position angle varies smoothly from about 10 degrees
to 40 degrees, in agreement with previous lower resolution maps. In a small
region south of the Orion ``hot core,'' however, the position angle changes by
90 degrees. This abrupt change in polarization direction is not necessarily the
signpost of a twisted magnetic field. Rather, in this localized region
processes other than the usual Davis-Greenstein mechanism might align the dust
grains with their long axes parallel with the field, orthogonal to their normal
orientation.Comment: AAS preprint:14 pages, 2 figures (3mm.eps and 1mm.eps); requires
aaspp4.sty To be published in Astrophysical Journal Letter
Brand Loyalty, Generic Entry and Price Competition in Pharmaceuticals in the Quarter Century After the 1984 Waxman-Hatch Legislation
The landmark Waxman-Hatch Act of 1984 represented a âgrand compromiseâ legislation that sought to balance incentives for innovation by establishing finite periods of market exclusivity yet simultaneously providing access to lower cost generics expeditiously following patent expiration. Here we examine trends in the first quarter century since passage of the legislation, building on earlier work by Grabowski and Vernon [1992,1996] and Cook [1998]. The generic share of retail prescriptions in the U.S. has grown from 18.6% in 1984 to 74.5% in 2009, with a notable acceleration in recent years. This increase reflects increases in both the share of the total market potentially accessible by generics, and the generic efficiency rate â the latter frequently approaching 100%. Whereas in 1994, the generic price index fell from 100 to 80 in the 12 months following initial generic entry and by 24 months to 65, in 2009 the comparable generic price indexes are 68 and 27, respectively. Recent studies sponsored by the American Association of Retired Persons focus only on brand prices and ignore substitution to lower priced options following loss of patent protection. For the prescription drugs most commonly used by beneficiaries in Medicare Part D, the average price per prescription declined by 21.3% from 2006 to 2009, rather than increasing by 25-28% as reported by the AARP. Finally, we quantify changes over time in the average daily cost of pharmaceutical treatment in nine major therapy areas, encompassing the entire set of molecules within each therapy class, not simply the molecule whose patent has expired. Across all nine therapeutic areas, at 24 months post-generic entry, the weighted mean reduction in pharmaceutical treatment cost per patient is 35.1%.
Impact of birth weight and gender on early postnatal hypothalamic energy balance regulatory gene expression in the young lamb
Peer reviewedPreprin
Characterizing Markets for Biopharmaceutical Innovations: Do Biologics Differ from Small Molecules?
Much has been written about the seemingly less formal, more agile biotechnology industry and its extensive interactions with academia and startups, as well as its distinct scientific, manufacturing and regulatory profile. Employing a data base encompassing all 96 biologics and 212 small molecules newly launched in the U.S. between 1998Q1 and 2008Q4, we compare their downstream clinical and commercial characteristics -- therapeutic class concentration, launch delays following approval, Orphan Drug and priority review status, supplemental indications, black box warning and safety record, and pricing and revenue growth during the product life cycle. We conclude that the market dynamics of biologics differ substantially from those of small molecules, although therapeutic class composition plays a major role.
Recommended from our members
Repeated sleep-quality assessment and use of sleep-promoting interventions in ICU.
To describe sleep quality using repeated subjective assessment and the ongoing use of sleep-promoting interventions in intensive care. It is well known that the critically ill experience sleep disruption while receiving treatment in the intensive care unit. Both the measurement and promotion of sleep is challenging in the complex environment of intensive care unit. Repeated subjective assessment of patients' sleep in the intensive care unit and use of sleep-promoting interventions has not been widely reported. An observational study was conducted in a 58-bed adult intensive care unit. Sleep quality was assessed using the Richards-Campbell Sleep Questionnaire (RCSQ) each morning. intensive care unit audit sleep-promoting intervention data were compared to data obtained prior to the implementation of a sleep guideline. Patients answered open-ended questions about the facilitators and deterrents of their sleep in intensive care unit. The sample (n = 50) was predominately male (76%) with a mean age: 62.6±16.9âyears. Sleep quality was assessed on 2âdays or more for 21 patients. The majority of patients (98%) received sleep-promoting interventions. Sleep quality had not improved significantly since the guideline was first implemented. The mean Richards-Campbell Sleep Questionnaire score was 47.9±24.1âmm. The main sleep deterrents were discomfort and noise. Frequently cited facilitators were nothing (i.e. nothing helped) and analgesia. The Richards-Campbell Sleep Questionnaire was used on repeated occasions, and sleep-promoting interventions were used extensively. There was no evidence of improvement in sleep quality since the implementation of a sleep guideline. The use of the Richards-Campbell Sleep Questionnaire for the subjective self-assessment of sleep quality in intensive care unit patients and the implementation of simple-promoting interventions by intensive care unit clinicians is both feasible and may be the most practical way to assess sleep in the intensive care unit context
Has The Era Of Slow Growth For Prescription Drug Spending Ended?
In the period 2005â13 the US prescription drug market grew at an average annual pace of only 1.8 percent in real terms on an invoice price basis (that is, in constant dollars and before manufacturersâ rebates and discounts). But the growth rate increased dramatically in 2014, when the market expanded by 11.5 percentâwhich raised questions about future trends. We determined the impact of manufacturersâ rebates and discounts on prices and identified the underlying factors likely to influence prescription spending over the next decade. These include a strengthening of the innovation pipeline; consolidation among buyers such as wholesalers, pharmacy benefit managers, and health insurers; and reduced incidence of patent expirations, which means that fewer less costly generic drug substitutes will enter the market than in the recent past. While various forecasts indicate that pharmaceutical spending growth will moderate from its 2014 level, the business tension between buyers and sellers could play out in many different ways. This suggests that future spending trends remain highly uncertain.United States. National Institutes of Health (NIANIH/R01AG043560
Entropy, non-ergodicity and non-Gaussian behaviour in ballistic transport
Ballistic transportation introduces new challenges in the thermodynamic
properties of a gas of particles. For example, violation of mixing, ergodicity
and of the fluctuation-dissipation theorem may occur, since all these processes
are connected. In this work, we obtain results for all ranges of diffusion,
i.e., both for subdiffusion and superdiffusion, where the bath is such that it
gives origin to a colored noise. In this way we obtain the skewness and the
non-Gaussian factor for the probability distribution function of the dynamical
variable. We put particular emphasis on ballistic diffusion, and we demonstrate
that in this case, although the second law of thermodynamics is preserved, the
entropy does not reach a maximum and a non-Gaussian behavior occurs. This
implies the non-applicability of the central limit theorem.Comment: 9 pages, 2 figure
- âŠ