439 research outputs found
Exactly solvable charged dilaton gravity theories in two dimensions
We find exactly solvable dilaton gravity theories containing a U(1) gauge
field in two dimensional space-time. The classical general solutions for the
gravity sector (the metric plus the dilaton field) of the theories coupled to a
massless complex scalar field are obtained in terms of the stress-energy tensor
and the U(1) current of the scalar field. We discuss issues that arise when we
attempt to use these models for the study of the gravitational back-reaction.Comment: The introductory part is changed. a version to appear in Class.
Quant. Grav. 6 pages, RevTe
Particle dynamics in a class of 2-dimensional gravity theories
We provide a method to determine the motion of a classical massive particle
in a background geometry of 2-dimensional gravity theories, for which the
Birkhoff theorem holds. In particular, we get the particle trajectory in a
continuous class of 2-dimensional dilaton gravity theories that includes the
Callan-Giddings-Harvey-Strominger (CGHS) model, the Jackiw-Teitelboim (JT)
model, and the -dimensional -wave Einstein gravity. The explicit
trajectory expressions for these theories are given along with the discussions
on the results.Comment: 15 pages, LaTeX. The deletion of the repeated portion of the abstract
and the proper line wrapping of the tex file. No other change
General Static Solutions of 2-dimensional Einstein-Dilaton-Maxwell-Scalar Theories
General static solutions of effectively 2-dimensional
Einstein-Dilaton-Maxwell-Scalar theories are obtained. Our model action
includes a class of 2-d dilaton gravity theories coupled with a gauge
field and a massless scalar field. Therefore it also describes the spherically
symmetric reduction of -dimensional Einstein-Scalar-Maxwell theories. The
properties of the analytic solutions are briefly discussed.Comment: 16 pages, Latex fil
U(N) Instantons on N=1/2 superspace -- exact solution & geometry of moduli space
We construct the exact solution of one (anti)instanton in N=1/2 super
Yang-Mills theory defined on non(anti)commutative superspace. We first identify
N = 1/2 superconformal invariance as maximal spacetime symmetry. For gauge
group U(2), SU(2) part of the solution is given by the standard
(anti)instanton, but U(1) field strength also turns out nonzero. The solution
is SO(4) rotationally symmetric. For gauge group U(N), in contrast to the U(2)
case, we show that the entire U(N) part of the solution is deformed by
non(anti)commutativity and fermion zero-modes. The solution is no longer
rotationally symmetric; it is polarized into an axially symmetric configuration
because of the underlying non(anti)commutativity. We compute the `information
metric' of one (anti) instanton. We find that moduli space geometry is deformed
from hyperbolic space (Euclidean anti-de Sitter space) in a way anticipated
from reduced spacetime symmetry. Remarkably, the volume measure of the moduli
space turns out to be independent of the non(anti)commutativity. Implications
to D-branes in Ramond- Ramond flux background and Maldacena's gauge-gravity
correspondence are discussed.Comment: 39 pages, 3 figures, JHEP style; v2. typos corrected + a paragraph
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Dose-adapted post-transplant cyclophosphamide for HLA-haploidentical transplantation in Fanconi anemia.
We developed a haploidentical transplantation protocol with post-transplant cyclophosphamide (CY) for in vivo T-cell depletion (TCD) using a novel adapted-dosing schedule (25 mg/kg on days +3 and +4) for Fanconi anemia (FA). With median follow-up of 3 years (range, 37 days to 6.2 years), all six patients engrafted. Two patients with multiple pre-transplant comorbidities died, one from sepsis and one from sepsis with associated chronic GVHD. Four patients without preexisting comorbidities and early transplant referrals are alive with 100% donor chimerism and excellent performance status. We conclude that adjusted-dosing post-transplant CY is effective in in vivo TCD to promote full donor engraftment in patients with FA
Infinite Lorentz boost along the M-theory circle and non-asymptotically flat solutions in supergravities
Certain non-asymptotically flat but supersymmetric classical solution of the
type IIA supergravity can be interpreted as the infinitely-boosted version of
the D-particle solution along the M-theory circle. By a chain of T-dual
transformations, this analysis also applies to yield non-asymptotically flat
solutions from the asymptotically flat and (non)-extremal solutions with
intersecting D-strings and D five-branes of the type IIB supergravity
compactified on a five-torus. Under S-duality, the non-asymptotically flat
solutions in this context can in particular be used to describe the
(1+1)-dimensional CGHS type black holes via spontaneous compactifications.Comment: 14 pages, Revte
Interacting Dipoles from Matrix Formulation of Noncommutative Gauge Theories
We study the IR behavior of noncommutative gauge theory in the matrix
formulation. We find that in this approach, the nature of the UV/IR mixing is
easily understood, which allows us to perform a reliable calculation of the
quantum effective action for the long wavelength modes of the noncommutative
gauge field. At one loop, we find that our description is weakly coupled only
in the supersymmetric theory. At two loops, we find non-trivial interaction
terms suggestive of dipole degrees of freedom. These dipoles exhibit a channel
duality reminiscent of string theory.Comment: LaTeX 11 pages, 4 figures; v.2 minor changes and some references
added; v.3 many more technical details added and significantly different
presentation, use REVTeX 4, to appear in PR
Links between the Big Dry in Australia and hemispheric multi-decadal climate variability – implications for water resource management
Southeast Australia (SEA) experienced a protracted drought during the
mid-1990s until early 2010 (known as the Big Dry or Millennium Drought) that
resulted in serious environmental, social and economic effects. This paper
analyses a range of historical climate data sets to place the recent drought
into context in terms of Southern Hemisphere inter-annual to multi-decadal
hydroclimatic variability. The findings indicate that the recent Big Dry in
SEA is in fact linked to the widespread Southern Hemisphere climate shift
towards drier conditions that began in the mid-1970s. However, it is shown
that this link is masked because the large-scale climate drivers responsible
for drying in other regions of the mid-latitudes since the mid-1970s did not
have the same effect on SEA during the mid- to late 1980s and early 1990s.
More specifically, smaller-scale synoptic processes resulted in elevated
autumn and winter rainfall (a crucial period for SEA hydrology) during the
mid- to late 1980s and early 1990s, which punctuated the longer-term drying.
From the mid-1990s to 2010 the frequency of the synoptic processes associated
with elevated autumn/winter rainfall decreased, resulting in a return to
drier than average conditions and the onset of the Big Dry. The findings
presented in this paper have marked implications for water management and
climate attribution studies in SEA, in particular for understanding and
dealing with "baseline" (i.e. current) hydroclimatic risks
Invasion of the central nervous system by Cryptococcus neoformans requires a secreted fungal metalloprotease.
UnlabelledCryptococcus spp. cause life-threatening fungal infection of the central nervous system (CNS), predominantly in patients with a compromised immune system. Why Cryptococcus neoformans has this remarkable tropism for the CNS is not clear. Recent research on cerebral pathogenesis of C. neoformans revealed a predominantly transcellular migration of cryptococci across the brain endothelium; however, the identities of key fungal virulence factors that function specifically to invade the CNS remain unresolved. Here we found that a novel, secreted metalloprotease (Mpr1) that we identified in the extracellular proteome of C. neoformans (CnMpr1) is required for establishing fungal disease in the CNS. Mpr1 belongs to a poorly characterized M36 class of fungalysins that are expressed in only some fungal species. A strain of C. neoformans lacking the gene encoding Mpr1 (mpr1Δ) failed to breach the endothelium in an in vitro model of the human blood-brain barrier (BBB). A mammalian host infected with the mpr1Δ null strain demonstrated significant improvement in survival due to a reduced brain fungal burden and lacked the brain pathology commonly associated with cryptococcal disease. The in vivo studies further indicate that Mpr1 is not required for fungal dissemination and Mpr1 likely targets the brain endothelium specifically. Remarkably, the sole expression of CnMPR1 in Saccharomyces cerevisiae resulted in a robust migration of yeast cells across the brain endothelium, demonstrating Mpr1's specific activity in breaching the BBB and suggesting that Mpr1 may function independently of the hyaluronic acid-CD44 pathway. This distinct role for Mpr1 may develop into innovative treatment options and facilitate a brain-specific drug delivery platform.ImportanceCryptococcus neoformans is a medically relevant fungal pathogen causing significant morbidity and mortality, particularly in immunocompromised individuals. An intriguing feature is its strong neurotropism, and consequently the hallmark of cryptococcal disease is a brain infection, cryptococcal meningoencephalitis. For C. neoformans to penetrate the central nervous system (CNS), it first breaches the blood-brain barrier via a transcellular pathway; however, the identities of fungal factors required for this transmigration remain largely unknown. In an effort to identify extracellular fungal proteins that could mediate interactions with the brain endothelium, we undertook a proteomic analysis of the extracellular proteome and identified a secreted metalloprotease (Mpr1) belonging to the M36 class of fungalysins. Here we found that Mpr1 promotes migration of C. neoformans across the brain endothelium and into the CNS by facilitating attachment of cryptococci to the endothelium surface, thus underscoring the critical role of M36 proteases in fungal pathogenesis
Path integral formulation of Hodge duality on the brane
In the warped compactification with a single Randall-Sundrum brane, a
puzzling claim has been made that scalar fields can be bound to the brane but
their Hodge dual higher-rank anti-symmetric tensors cannot. By explicitly
requiring the Hodge duality, a prescription to resolve this puzzle was recently
proposed by Duff and Liu. In this note, we implement the Hodge duality via path
integral formulation in the presence of the background gravity fields of warped
compactifications. It is shown that the prescription of Duff and Liu can be
naturally understood within this framework.Comment: 7 pages, LaTe
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