Exactly solvable charged dilaton gravity theories in two dimensions

We find exactly solvable dilaton gravity theories containing a U(1) gauge field in two dimensional space-time. The classical general solutions for the gravity sector (the metric plus the dilaton field) of the theories coupled to a massless complex scalar field are obtained in terms of the stress-energy tensor and the U(1) current of the scalar field. We discuss issues that arise when we attempt to use these models for the study of the gravitational back-reaction.Comment: The introductory part is changed. a version to appear in Class. Quant. Grav. 6 pages, RevTe

Particle dynamics in a class of 2-dimensional gravity theories

We provide a method to determine the motion of a classical massive particle in a background geometry of 2-dimensional gravity theories, for which the Birkhoff theorem holds. In particular, we get the particle trajectory in a continuous class of 2-dimensional dilaton gravity theories that includes the Callan-Giddings-Harvey-Strominger (CGHS) model, the Jackiw-Teitelboim (JT) model, and the $d$-dimensional $s$-wave Einstein gravity. The explicit trajectory expressions for these theories are given along with the discussions on the results.Comment: 15 pages, LaTeX. The deletion of the repeated portion of the abstract and the proper line wrapping of the tex file. No other change

General Static Solutions of 2-dimensional Einstein-Dilaton-Maxwell-Scalar Theories

General static solutions of effectively 2-dimensional Einstein-Dilaton-Maxwell-Scalar theories are obtained. Our model action includes a class of 2-d dilaton gravity theories coupled with a $U(1)$ gauge field and a massless scalar field. Therefore it also describes the spherically symmetric reduction of $d$-dimensional Einstein-Scalar-Maxwell theories. The properties of the analytic solutions are briefly discussed.Comment: 16 pages, Latex fil

U(N) Instantons on N=1/2 superspace -- exact solution & geometry of moduli space

We construct the exact solution of one (anti)instanton in N=1/2 super Yang-Mills theory defined on non(anti)commutative superspace. We first identify N = 1/2 superconformal invariance as maximal spacetime symmetry. For gauge group U(2), SU(2) part of the solution is given by the standard (anti)instanton, but U(1) field strength also turns out nonzero. The solution is SO(4) rotationally symmetric. For gauge group U(N), in contrast to the U(2) case, we show that the entire U(N) part of the solution is deformed by non(anti)commutativity and fermion zero-modes. The solution is no longer rotationally symmetric; it is polarized into an axially symmetric configuration because of the underlying non(anti)commutativity. We compute the `information metric' of one (anti) instanton. We find that moduli space geometry is deformed from hyperbolic space (Euclidean anti-de Sitter space) in a way anticipated from reduced spacetime symmetry. Remarkably, the volume measure of the moduli space turns out to be independent of the non(anti)commutativity. Implications to D-branes in Ramond- Ramond flux background and Maldacena's gauge-gravity correspondence are discussed.Comment: 39 pages, 3 figures, JHEP style; v2. typos corrected + a paragraph adde

Dose-adapted post-transplant cyclophosphamide for HLA-haploidentical transplantation in Fanconi anemia.

We developed a haploidentical transplantation protocol with post-transplant cyclophosphamide (CY) for in vivo T-cell depletion (TCD) using a novel adapted-dosing schedule (25 mg/kg on days +3 and +4) for Fanconi anemia (FA). With median follow-up of 3 years (range, 37 days to 6.2 years), all six patients engrafted. Two patients with multiple pre-transplant comorbidities died, one from sepsis and one from sepsis with associated chronic GVHD. Four patients without preexisting comorbidities and early transplant referrals are alive with 100% donor chimerism and excellent performance status. We conclude that adjusted-dosing post-transplant CY is effective in in vivo TCD to promote full donor engraftment in patients with FA

Infinite Lorentz boost along the M-theory circle and non-asymptotically flat solutions in supergravities

Certain non-asymptotically flat but supersymmetric classical solution of the type IIA supergravity can be interpreted as the infinitely-boosted version of the D-particle solution along the M-theory circle. By a chain of T-dual transformations, this analysis also applies to yield non-asymptotically flat solutions from the asymptotically flat and (non)-extremal solutions with intersecting D-strings and D five-branes of the type IIB supergravity compactified on a five-torus. Under S-duality, the non-asymptotically flat solutions in this context can in particular be used to describe the (1+1)-dimensional CGHS type black holes via spontaneous compactifications.Comment: 14 pages, Revte

Interacting Dipoles from Matrix Formulation of Noncommutative Gauge Theories

We study the IR behavior of noncommutative gauge theory in the matrix formulation. We find that in this approach, the nature of the UV/IR mixing is easily understood, which allows us to perform a reliable calculation of the quantum effective action for the long wavelength modes of the noncommutative gauge field. At one loop, we find that our description is weakly coupled only in the supersymmetric theory. At two loops, we find non-trivial interaction terms suggestive of dipole degrees of freedom. These dipoles exhibit a channel duality reminiscent of string theory.Comment: LaTeX 11 pages, 4 figures; v.2 minor changes and some references added; v.3 many more technical details added and significantly different presentation, use REVTeX 4, to appear in PR

Links between the Big Dry in Australia and hemispheric multi-decadal climate variability – implications for water resource management

Southeast Australia (SEA) experienced a protracted drought during the mid-1990s until early 2010 (known as the Big Dry or Millennium Drought) that resulted in serious environmental, social and economic effects. This paper analyses a range of historical climate data sets to place the recent drought into context in terms of Southern Hemisphere inter-annual to multi-decadal hydroclimatic variability. The findings indicate that the recent Big Dry in SEA is in fact linked to the widespread Southern Hemisphere climate shift towards drier conditions that began in the mid-1970s. However, it is shown that this link is masked because the large-scale climate drivers responsible for drying in other regions of the mid-latitudes since the mid-1970s did not have the same effect on SEA during the mid- to late 1980s and early 1990s. More specifically, smaller-scale synoptic processes resulted in elevated autumn and winter rainfall (a crucial period for SEA hydrology) during the mid- to late 1980s and early 1990s, which punctuated the longer-term drying. From the mid-1990s to 2010 the frequency of the synoptic processes associated with elevated autumn/winter rainfall decreased, resulting in a return to drier than average conditions and the onset of the Big Dry. The findings presented in this paper have marked implications for water management and climate attribution studies in SEA, in particular for understanding and dealing with "baseline" (i.e. current) hydroclimatic risks

Invasion of the central nervous system by Cryptococcus neoformans requires a secreted fungal metalloprotease.

UnlabelledCryptococcus spp. cause life-threatening fungal infection of the central nervous system (CNS), predominantly in patients with a compromised immune system. Why Cryptococcus neoformans has this remarkable tropism for the CNS is not clear. Recent research on cerebral pathogenesis of C. neoformans revealed a predominantly transcellular migration of cryptococci across the brain endothelium; however, the identities of key fungal virulence factors that function specifically to invade the CNS remain unresolved. Here we found that a novel, secreted metalloprotease (Mpr1) that we identified in the extracellular proteome of C. neoformans (CnMpr1) is required for establishing fungal disease in the CNS. Mpr1 belongs to a poorly characterized M36 class of fungalysins that are expressed in only some fungal species. A strain of C. neoformans lacking the gene encoding Mpr1 (mpr1Δ) failed to breach the endothelium in an in vitro model of the human blood-brain barrier (BBB). A mammalian host infected with the mpr1Δ null strain demonstrated significant improvement in survival due to a reduced brain fungal burden and lacked the brain pathology commonly associated with cryptococcal disease. The in vivo studies further indicate that Mpr1 is not required for fungal dissemination and Mpr1 likely targets the brain endothelium specifically. Remarkably, the sole expression of CnMPR1 in Saccharomyces cerevisiae resulted in a robust migration of yeast cells across the brain endothelium, demonstrating Mpr1's specific activity in breaching the BBB and suggesting that Mpr1 may function independently of the hyaluronic acid-CD44 pathway. This distinct role for Mpr1 may develop into innovative treatment options and facilitate a brain-specific drug delivery platform.ImportanceCryptococcus neoformans is a medically relevant fungal pathogen causing significant morbidity and mortality, particularly in immunocompromised individuals. An intriguing feature is its strong neurotropism, and consequently the hallmark of cryptococcal disease is a brain infection, cryptococcal meningoencephalitis. For C. neoformans to penetrate the central nervous system (CNS), it first breaches the blood-brain barrier via a transcellular pathway; however, the identities of fungal factors required for this transmigration remain largely unknown. In an effort to identify extracellular fungal proteins that could mediate interactions with the brain endothelium, we undertook a proteomic analysis of the extracellular proteome and identified a secreted metalloprotease (Mpr1) belonging to the M36 class of fungalysins. Here we found that Mpr1 promotes migration of C. neoformans across the brain endothelium and into the CNS by facilitating attachment of cryptococci to the endothelium surface, thus underscoring the critical role of M36 proteases in fungal pathogenesis

Thermodynamics of doubly charged CGHS model and D1-D5-KK black holes of IIB supergravity

We study the doubly charged Callan-Giddings-Harvey-Strominger (CGHS) model, which has black hole solutions that were found to be U-dual to the D1-D5-KK black holes of the IIB supergravity. We derive the action of the model via a spontaneous compactification on S^3 of the IIB supergravity on S^1*T^4 and obtain the general static solutions including black holes corresponding to certain non-asymptotically flat black holes in the IIB supergravity. Thermodynamics of them is established by computing the entropy, temperature, chemical potentials, and mass in the two-dimensional setup, and the first law of thermodynamics is explicitly verified. The entropy is in precise agreement with that of the D1-D5-KK black holes, and the mass turns out to be consistent with the infinite Lorentz boost along the M theory circle that is a part of the aforementioned U-dual chain.Comment: 21 pages, Revte