Docking Studies, Synthesis, Characterization and Evaluation of Their Antioxidant and Cytotoxic Activities of Some Novel Isoxazole-Substituted 9-Anilinoacridine Derivatives

A convenient synthesis of novel isoxazole-substituted 9-anilinoacridine derivatives 5a–j was reported. The compounds were confirmed by physical and analytical data and screened for in vitro antioxidant activity by DPPH method, reducing power assay and total antioxidant capacity method. The cytotoxic activity of the compounds was also studied in HEp-2 cell line. The docking studies of the synthesized compounds were performed towards the key nucleoside dsDNA by using AutoDock vina 4.0 programme. All the isoxazole-substituted compounds have significant activities

Rice Production in Sri Lanka

Crop Production/Industries,

Efficiency and productivity change across the economic sectors in Lithuania (2000–2010): the DEA–MULTIMOORA approach

Reasonable strategic management requires the complex assessment of the regulated area. This study, thus, presents a multi-criteria framework for frontier assessment of efficiency and productivity across the Lithuanian economic sectors throughout 2000–2010. The data envelopment analysis was employed to estimate efficiency in terms of an output indicator (value added) and input indicators (intermediate consumption, capital consumption, and remunerations). Furthermore, the decomposition of the Malmquist productivity index enabled to describe the impact of frontier shifts and catch-up effect on the overall change in efficiency. The multi-criteria decision making method MULTIMOORA aggregated different indicators of efficiency and productivity and thus resulted in the ranking of the economic sectors. The analysis suggests that services sector was the most efficient one, whereas manufacturing was second best. Certain branches of manufacturing, namely pharmaceutical, wood, food, and furniture industry, were rather efficient