1,780 research outputs found
Fast-Light in a Photorefractive Crystal for Gravitational Wave Detection
We demonstrate superluminal light propagation using two frequency multiplexed
pump beams to produce a gain doublet in a photorefractive crystal of Ce:BaTiO3.
The two gain lines are obtained by two-wave mixing between a probe field and
two individual pump fields. The angular frequencies of the pumps are
symmetrically tuned from the frequency of the probe. The frequency difference
between the pumps corresponds to the separation of the two gain lines; as it
increases, the crystal gradually converts from normal dispersion without
detuning to an anomalously dispersive medium. The time advance is measured as
0.28 sec for a pulse propagating through a medium with a 2Hz gain separation,
compared to the same pulse propagating through empty space. We also demonstrate
directly anomalous dispersion profile using a modfied experimental
configuration. Finally, we discuss how anomalous dispersion produced this way
in a faster photorefractive crystal (such as SPS: Sn2P2S6) could be employed to
enhance the sensitivity-bandwidth product of a LIGO type gravitational wave
detector augmented by a White Light Cavity.Comment: 14 pages, 5 figure
Cavity Nonlinear Optics at Low Photon Numbers from Collective Atomic Motion
We report on Kerr nonlinearity and dispersive optical bistability of a
Fabry-Perot optical resonator due to the displacement of ultracold atoms
trapped within. In the driven resonator, such collective motion is induced by
optical forces acting upon up to Rb atoms prepared in the lowest
band of a one-dimensional intracavity optical lattice. The longevity of atomic
motional coherence allows for strongly nonlinear optics at extremely low cavity
photon numbers, as demonstrated by the observation of both branches of optical
bistability at photon numbers below unity.Comment: 4 pages, 3 figures. Modifed following reviewer comment
Altered metabolic pathways elucidated via untargeted in vivo toxicometabolomics in rat urine and plasma samples collected after controlled application of a human equivalent amphetamine dose
Amphetamine is widely consumed as drug of abuse due to its stimulating and cognitive enhancing effects. Since amphetamine has been on the market for quite a long time and it is one of the most commonly used stimulants worldwide, to date there is still limited information on its effects on the metabolome. In recent years, untargeted toxicometabolomics have been increasingly used to study toxicity-related pathways of such drugs of abuse to find and identify important endogenous and exogenous biomarkers. In this study, the acute effects of amphetamine intake on plasma and urinary metabolome in rats were investigated. For this purpose, samples of male Wistar rats after a single dose of amphetamine (5 mg/kg) were compared to a control group using an untargeted metabolomics approach. Analysis was performed using normal and reversed phase liquid chromatography coupled to high-resolution mass spectrometry using positive and negative ionization mode. Statistical evaluation was performed using Welch’s two-sample t test, hierarchical clustering, as well as principal component analysis. The results of this study demonstrate a downregulation of amino acids in plasma samples after amphetamine exposure. Furthermore, four new potential biomarkers N-acetylamphetamine, N-acetyl-4-hydroxyamphetamine, N-acetyl-4-hydroxyamphetamine glucuronide, and amphetamine succinate were identified in urine. The present study complements previous data and shows that several studies are necessary to elucidate altered metabolic pathways associated with acute amphetamine exposure
- …