Clock Quantum Monte Carlo: an imaginary-time method for real-time quantum dynamics

In quantum information theory, there is an explicit mapping between general unitary dynamics and Hermitian ground state eigenvalue problems known as the Feynman-Kitaev Clock. A prominent family of methods for the study of quantum ground states are quantum Monte Carlo methods, and recently the full configuration interaction quantum Monte Carlo (FCIQMC) method has demonstrated great promise for practical systems. We combine the Feynman-Kitaev Clock with FCIQMC to formulate a new technique for the study of quantum dynamics problems. Numerical examples using quantum circuits are provided as well as a technique to further mitigate the sign problem through time-dependent basis rotations. Moreover, this method allows one to combine the parallelism of Monte Carlo techniques with the locality of time to yield an effective parallel-in-time simulation technique

The Sun as a Star: 13 years of SoHO

The best known Solar oscillation-like star is the Sun. During the last 14 years, the ESA/NASA Solar and Heliospheric Observatory (SoHO) has been continuously observing this star from the Lagrange point L1 with an enormous success. Among the 11 instruments placed onboard, 3 of them are dedicated to helioseismology: GOLF, VIRGO and MDI. The first two observe the Sun as a star by integrating the velocity or intensity signal of the visible solar disk into a single point. They are thus similar to any other observation done in asteroseismology. During this review I will present the most important results obtained during the mission concerning the Sun seen as a star and how this results have evolved our thoughts of the inside of our star.Comment: Proceedings of the Stellar Pulsation Conference. Santa Fe. 6 pages, 4 figure

Anti‐atherosclerotic effect of the angiotensin 1–7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis

Background and Purpose: Inflammation plays a key role in atherosclerosis. A protective role of angiotensin-(1-7) in vascular pathologies opened a possibility for therapeutic use of small molecule non-peptide Ang-(1-7) mimetics, such as AVE0991. The mechanisms of these vaso-protective effects of a Mas receptor agonist, AVE0991, remain unclear. Experimental approach: We investigated the effects of AVE0991 on the spontaneous atherosclerosis in ApoE-/- mice, in the context of vascular inflammation and plaque stability. Key Results: AVE0991 has significant anti-atherosclerotic properties in ApoE-/- mice and increases plaque stability, by reducing plaque macrophage content, without effects on collagen. Using descending aorta of chow fed ApoE-/- mice, before significant atherosclerotic plaque develops, we gained insight to early events in atherosclerosis. Interestingly, perivascular adipose tissue (pVAT) and adventitial infiltration with macrophages and T cells precedes atherosclerotic plaque or the impairment of endothelium-dependent NO bioavailability as a measure of endothelial function. AVE0991 inhibited perivascular inflammation, through the reduction of chemokine expression in pVAT, as well as through direct actions on monocytes/macrophages inhibiting their activation, characterized by IL-1β, TNF-α, MCP-1 and CXCL10 and differentiation to M1 phenotype. Pre-treatment with AVE0991 inhibited migration of THP-1 monocytes towards supernatants of activated adipocytes (SW872). Mas receptors were expressed in pVAT and in THP-1 cells in vitro and anti-inflammatory effects of AVE0991 were partially Mas dependent. Conclusions & implications: Selective Mas receptor agonist AVE0991 possesses anti-atherosclerotic and anti-inflammatory properties, affecting monocyte/macrophage differentiation and recruitment to perivascular space at early stages of atherosclerosis in ApoE-/- mice

Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms

Hypertension and type 2 diabetes are common comorbidities. Hypertension is twice as frequent in patients with diabetes compared with those who do not have diabetes. Moreover, patients with hypertension often exhibit insulin resistance and are at greater risk of diabetes developing than are normotensive individuals. The major cause of morbidity and mortality in diabetes is cardiovascular disease, which is exacerbated by hypertension. Accordingly, diabetes and hypertension are closely interlinked because of similar risk factors, such as endothelial dysfunction, vascular inflammation, arterial remodelling, atherosclerosis, dyslipidemia, and obesity. There is also substantial overlap in the cardiovascular complications of diabetes and hypertension related primarily to microvascular and macrovascular disease. Common mechanisms, such as upregulation of the renin-angiotensin-aldosterone system, oxidative stress, inflammation, and activation of the immune system likely contribute to the close relationship between diabetes and hypertension. In this article we discuss diabetes and hypertension as comorbidities and discuss the pathophysiological features of vascular complications associated with these conditions. We also highlight some vascular mechanisms that predispose to both conditions, focusing on advanced glycation end products, oxidative stress, inflammation, the immune system, and microRNAs. Finally, we provide some insights into current therapies targeting diabetes and cardiovascular complications and introduce some new agents that may have vasoprotective therapeutic potential in diabetes

Beam phase and intensity monitor (BPIM) for the LHCb Experiment

The LHC bunch clock is transmitted over kilometres of fibre to the experiments where it is distributed to thousands of front-end electronics boards. In order to ensure that the detector signals are sampled properly, its long-term stability with respect to the bunch arrival times must be monitored with a precision of <100ps. In addition it is important to monitor the trigger conditions by measuring the intensity of each bunch locally in the experiment. For this purpose, we propose a beam phase and intensity acquisition board (BPIM) for the Button Electrode Beam Pick-ups which will be installed on both sides of the LHCb interaction point. The board measures the two quantities per bunch, and processes the information in an onboard FPGA. The information is read-out by the Experiment Control System and is directly fed to the LHCb Timing and Fast Control (TFC) [1]. In the TFC system the information is included in an event data bank but may also be used as a bunch crossing trigger or gate

Evidence of increasing acoustic emissivity at high frequency with solar cycle 23 in Sun-as-a-star observations

We used long high-quality unresolved (Sun-as-a-star observations) data collected by GOLF and VIRGO instruments on board the ESA/NASA SOHO satellite to investigate the amplitude variation with solar cycle 23 in the high-frequency band (5.7 < nu< 6.3 mHz). We found an enhancement of acoustic emissivity over the ascending phase of about 18+-3 in velocity observations and a slight enhancement of 3+-2 in intensity. Mode conversion from fast acoustic to fast magneto-acoustic waves could explain the enhancement in velocity observations. These findings open up the possibility to apply the same technique to stellar intensity data, in order to investigate stellar-magnetic activity.Comment: Proceedings of the Stellar Pulsation. Santa Fe, USA. 3 pages, 5 figure