CLINICAL CASE OF RESUMPTION OF ANTICOAGULANT THERAPY AFTER IMPLANTATION OF THE AMPLATZER CARDIAC PLUG LEFT ATRIAL APPENDAGE OCCLUDER

The article demonstrates a clinical case of forced renewal of anticoagulant therapy after the endovascular closure of the left atrial appendage. Patient with atrial fibrillation and high risk of thromboembolic complications and bleeding on the background of warfarin administration and inappropriate INR values had an acute hemorrhagic cerebral blood flow disorder developed. Endovascular closure of the left atrial appendage was performed. However, the thrombosis of the area of the delivery system fastening revealed after 12 months was an indication for the resumption of anticoagulant therapy.The article presents modern data on the use of occluders for closing the left atrial appendage, the frequency of complications and antiplatelet therapy schemes depending on the presence of thrombosis risk factors and bleeding

КЛИНИЧЕСКИЙ СЛУЧАЙ ВОЗОБНОВЛЕНИЯ АНТИКОАГУЛЯНТНОЙ ТЕРАПИИ ПОСЛЕ ИМПЛАНТАЦИИ ОККЛЮДЕРА УШКА ЛЕВОГО ПРЕДСЕРДИЯ AMPLATZER CARDIAC PLUG

The article demonstrates a clinical case of forced renewal of anticoagulant therapy after the endovascular closure of the left atrial appendage. Patient with atrial fibrillation and high risk of thromboembolic complications and bleeding on the background of warfarin administration and inappropriate INR values had an acute hemorrhagic cerebral blood flow disorder developed. Endovascular closure of the left atrial appendage was performed. However, the thrombosis of the area of the delivery system fastening revealed after 12 months was an indication for the resumption of anticoagulant therapy.The article presents modern data on the use of occluders for closing the left atrial appendage, the frequency of complications and antiplatelet therapy schemes depending on the presence of thrombosis risk factors and bleeding.В статье демонстрируется клинический случай вынужденного возобновления антикоагулянтной терапии после эндоваскулярного закрытия ушка левого предсердия. У больного с фибрилляцией предсердий и высоким риском тромбоэмболических осложнений и кровотечений на фоне приема варфарина и нецелевых значений МНО развилось острое нарушение мозгового кровообращения по геморрагическому типу. Было выполнено эндоваскулярное закрытие ушка левого предсердия. Однако выявленный через 12 мес. тромбоз области крепления доставочной системы явился показанием для возобновления антикоагулянтной терапии.В статье приводятся современные данные об использовании окклюдеров для закрытия ушка левого предсердия, частоте осложнений и схемах антитромботической терапии в зависимости от наличия факторов риска тромбоза и кровотечений

ENDOVASCULAR METHODS FOR CLOSURE OF THE LEFT ATRIAL APPENDAGE IN PATIENTS WITH NONVALVULAR ATRIAL FIBRILLATION FOR STROKE PREVENTION

The paper presents an update on endovascular methods for closure of the left atrial appendage in order to prevent thromboembolic events in patients with nonvalvular atrial fibrillation. It analyzes the results of occlusion devices as an alternative to longterm anticoagulant therapy from the standpoint of evidencebased medicine, advantages, and features of design and implantation of occlusion devices, such as Watchman, Amplatzer, WaveCrest, and Lariat system. Literature searching was carried out using the databases PubMed and Scopus

CLINICAL CASE OF RESUMPTION OF ANTICOAGULANT THERAPY AFTER IMPLANTATION OF THE AMPLATZER CARDIAC PLUG LEFT ATRIAL APPENDAGE OCCLUDER

The article demonstrates a clinical case of forced renewal of anticoagulant therapy after the endovascular closure of the left atrial appendage. Patient with atrial fibrillation and high risk of thromboembolic complications and bleeding on the background of warfarin administration and inappropriate INR values had an acute hemorrhagic cerebral blood flow disorder developed. Endovascular closure of the left atrial appendage was performed. However, the thrombosis of the area of the delivery system fastening revealed after 12 months was an indication for the resumption of anticoagulant therapy.The article presents modern data on the use of occluders for closing the left atrial appendage, the frequency of complications and antiplatelet therapy schemes depending on the presence of thrombosis risk factors and bleeding.</jats:p

Use of cardiac imaging in chronic coronary syndromes: the EURECA Imaging registry.

Abstract Background The prospective, multicentre EURECA registry assessed the use of imaging and adoption of the European Society of Cardiology (ESC) Guidelines (GL) in patients with chronic coronary syndromes (CCS). Methods Between May 2019 and March 2020, 5156 patients were recruited in 73 centres from 24 ESC member countries. The adoption of GL recommendations was evaluated according to clinical presentation and pre-test probability (PTP) of obstructive coronary artery disease (CAD). Results The mean age of the population was 64 ± 11 years, 60% of patients were males, 42% had PTP &amp;gt;15%, 27% had previous CAD, and ejection fraction was &amp;lt;50% in 5%. Exercise ECG was performed in 32% of patients, stress imaging as the first choice in 40%, and computed tomography coronary angiography (CTCA) in 22%. Invasive coronary angiography (ICA) was the first or downstream test in 17% and 11%, respectively. Obstructive CAD was documented in 24% of patients, inducible ischaemia in 19%, and 13% of patients underwent revascularization. In 44% of patients, the overall diagnostic process did not adopt the GL. In these patients, referral to stress imaging (21% vs. 58%; P &amp;lt; 0.001) or CTCA (17% vs. 30%; P &amp;lt; 0.001) was less frequent, while exercise ECG (43% vs. 22%; P &amp;lt; 0.001) and ICA (48% vs. 15%; P &amp;lt; 0.001) were more frequently performed. The adoption of GL was associated with fewer ICA, higher proportion of diagnosis of obstructive CAD (60% vs. 39%, P &amp;lt; 0.001) and revascularization (54% vs. 37%, P &amp;lt; 0.001), higher quality of life, fewer additional testing, and longer times to late revascularization. Conclusions In patients with CCS, current clinical practice does not adopt GL recommendations on the use of diagnostic tests in a significant proportion of patients. When the diagnostic approach adopts GL recommendations, invasive procedures are less frequently used and the diagnostic yield and therapeutic utility are superior. </jats:sec