The Efficacy of Selected Desensitizing OTC Products: A Systematic Review.

Licensed by the Creative Commons Attribution LicenseObjectives. The aim of the present study was to review the published literature in order to identify relevant studies for inclusion and to determine whether there was any evidence on the clinical effectiveness of selected desensitizing toothpastes, calcium sodium phosphosilicate (CSPS), amorphous calcium phosphate (ACP), nanohydroxyapatite, and casein phosphopeptide-amorphous calcium phosphate (tooth mousse) on reducing dentine hypersensitivity (DH). Materials and Methods. Following a review of 593 papers identified from searching both electronic databases (PUBMED) and hand searching of relevant written journals, only 5 papers were accepted for inclusion. Results. Analysis of the included studies (3 CSPS and 2 ACP) would suggest that there may be some benefit for patients using these products for reducing DH. No direct comparative studies were available to assess all these products under the same conditions neither were there any comparative randomised controlled studies that compared at least two of these products in determining their effectiveness in treating DH. Conclusions. Due to the small number of included studies, there are limited clinical data to support any claims of clinical efficacy of these OTC products. Further studies are therefore required to determine the efficacy of these products in well-controlled RCT studies with a larger sample size

In Vitro Evaluation of the Abrasiveness of Novel Bioactive Glass Powders (Biominf®) on Ivory Dentine in Air Polishing Procedures Compared to Selected Reference Powders

Objectives: To evaluate the abrasiveness of novel Bioactive Glass Powders (BiominF®) on Ivory Dentine compared to selected reference powders. Materials and Methods: Ivory dentine was used as the study sample. Bioactive glasses (Biomin F® and Sylc® Blend) was compared with sodium bicarbonate, glycine, erythritol powders. Particle size analysis and powder output rate were undertaken. The powders were applied for 5 and 10s in a standardized procedure. Evaluation of wear depth on dentine in μm was assessed using White Light Profilometry. Results: BiominF®, Glycine, and erythritol powders showed similar powder output rates. Bioactive glasses (BiominF® and Sylc® Blend) resulted in significantly deeper wear depth compared to references powders. There were no significant differences in wear depth between sodium bicarbonate, glycine, and erythritol powders. Conclusions: Bioactive glasses (BiominF® and Sylc® Blend) were significant more abrasive than sodium bicarbonate, glycine, and erythritol powders. Clinical Relevance: Application of bioactive glasses powder on the root surface should be used with caution despite the desensitizing effect and the promotion of remineralization

The use of a Novel Bioactive Glass in Air Polishing

Aims: To determine the abrasiveness of using a novel bioactive glass (BioMin™ F) in air polishing for subgingival root debridement by measuring dentine loss and compare this value to the reference powders. Furthermore, to confirm the tubular occlusion effect of air polishing with the bioactive glass using Scanning Electron Microscopy techniques. Material and Methods: Ivory derived from an elephant’s tusk was used as the study sample. A balled milled BioMin™ F powder (D90 = 87.9 μm), was used as the test powder; This choice was based on a previously performed pilot study [1]. This powder was compared to two reference powders, sodium bicarbonate and glycine. Each powder group constituted of six samples of ivory. The dentine lost was measured in μm using white light profilometry. Scanning electron microscopy was performed for all the tested powders, to evaluate particle shape, and to the study samples to assess the effect of the air abrasive/polishing procedure on dentinal tubules. Results: The depth of dentine removed (mean ± standard deviation) of the test group, air polishing with the bioactive glass, was 11.0 ± 1.05 μm, control group 1, air polishing with sodium bicarbonate, was 44.1 ± 0.77μm, and control group 2, air polishing with glycine, was 28.1 ± 1.87μm. The differences between the three groups were statistically significant. SEM images showed a partial tubular occlusion effect in the test group, and this was absent in both control groups. Conclusion: The novel bioactive glass, BioMin™ F, with ball milled particles 90% sized less than 87.9 μm, was significantly more conservative than sodium bicarbonate powder and glycine powder. There was evidence of partial tubular occlusion following bioactive glass air polishing; however, no tubular occlusion was evident in the samples treated with either sodium bicarbonate or glycine air polishing

Prevalence of Moderate to Severe Periodontitis in an 18–19th Century Sample—St. Bride’s Lower Churchyard (London, UK)

The aim of the study was to determine the prevalence of moderate to severe periodontitis in 18–19th century skulls in the St Bride’s Lower Churchyard in London, UK. Materials and methods: A total of 105 adult skulls (66 M: F 39) from the Museum of London collection were examined for evidence of dental disease. The primary method was to measure the presence of moderate to severe periodontitis. Other dental pathologies were recorded such as tooth wear, calculus, and caries. Results: Overall, the prevalence of moderate to severe periodontitis in the sample was 21–24%. Males were observed to be more susceptible to periodontal disease than females. The severity of bone loss in the skull collection also increased with age. There was no significant difference in the amount of calculus deposition when comparing either age or sex. A total of 14% of the individuals in the sample showed signs of smoking. Conclusion: The results of the study indicated that the prevalence of moderate to severe periodontitis in an 18–19th century skull sample was 21–24%, which was higher than in previous studies. This may be due to the lack of basic personal mouth care and professional dental treatment as well as known risk factors such as smoking, stress, low socioeconomic status, and malnutrition

An In Vitro Comparison of A Novel Self-Assembling Peptide Matrix Gel and Selected Desensitizing Toothpastes in Reducing Fluid Flow by Dentine Tubular Occlusion

Objectives: The objective of this explorative in vitro study was to evaluate the ability of a novel self-assembling peptide matrix gel with calcium phosphate in effectively occluding dentine tubules compared to selected desensitizing toothpastes. Methods: Mid-coronal dentine discs with a thickness of 1 mm were sectioned from caries-free human molars. The discs were etched with 6% citric acid for 2 minutes, halved and subjected to a 2-minute brushing with a novel gel (SAPM) and three selected desensitizing toothpastes ([SRP], [SRR] and [CSP]). The ability of the desensitizing gel and toothpastes to occlude the dentine tubules was assessed and compared before and after brushing using Scanning Electron Microscopy (SEM) on both etched and fractured dentine surfaces. The SEM observations were supplemented by hydraulic conductance measurements using a modified Pashley model before and after tooth brushing (n=5). Results: The results demonstrated that there was a reduction in both the number and the diameter of the open dentine tubules, which was evident for all the treated dentine discs. The particles that occluded the open dentine tubules, however had different morphologies and distribution. The selfassembling peptide matrix gel (SAPM) demonstrated greater reduction in the number of open tubules compared to the other desensitizing toothpastes. Reductions in the hydraulic conductance measurements were observed for all tested materials (mean [SD, %]: SAPM 55.1 [12.5], SRP 64.9 [18.5], SRR 39.1 [17.1] and CSP 27.6 [6.8]). No statistically differences were observed between the SAPM and SRP, SRR toothpastes (paired t-Test; ≤0.05) although a significant difference was noted between the SAPM and the CSP toothpastes. There was an overall trend for reduction for the SAPM compared to the SRR toothpaste. Conclusion: The results would suggest that a novel self-assembling peptide matrix gel (SAPM) was effective in blocking the dentine tubules and may therefore have the potential to be an effective desensitizing product for the treatment of Dentine Hypersensitivity

Quantifying the Effect of Adding Alkaline Phosphatase Enzyme to Silicate/Phosphate Glass Mixtures to Enhance Bone Regeneration

Bioactive silicate glass-based (PerioGlas®) has been previously used to enhance periodontal bone regeneration. However, the degradation of this glass in the body fluid generates a high pH (>8) which may enhance the growth of periodontopathic bacteria, such as Porphyromonas gingivalis (P. gingivalis) thereby inhibiting osteoblastic activity. The aim of this study was to: (i) develop a mixture of a phosphate and silicate glass to produce a more neutral pH environment where the alkaline pH arising from the bioactive silicate glass can be offset by the acidity of phosphate glass, (ii) whether the alkaline phosphatase enzyme (ALP) when added to the silicate/phosphate glass mixture can enzymatically hydrolyse the Q2 metaphosphate chains to release Q0 orthophosphate species that can be used in forming apatite and bone mineralization. For this purpose, nine compositions of bioactive silicate/ phosphate glass-mixtures were prepared. The glass bioactivity was performed by immersing the prepared glass mixtures in ALP containing Tris buffer solution. The pH change in solutions was measured as a function of time. The glass mixtures degradation and apatite formation were investigated by 31P Solid and 31P Solution Nuclear Magnetic Resonance (NMR) spectroscopies. The results showed that the pH behaviour was modulated by immersing the glass-mixtures in buffered solutions. Solid and Solution NMR revealed that the terminal Q1 species belonging to the Q2-metaphosphate chains was hydrolysed by the ALP and converted into a Q0 orthophosphate species. In conclusion, the glass mixtures regulated the pH through its degradation stepwise on immersion. The output of the NMR spectra significantly supported the enzymatic degradation of glass mixtures with ALP enabling apatite precipitation for new bone formation. The concept of using silicate/phosphate glass mixtures with ALP is innovative and pioneering technology, suggesting its potentiality to develop new biomedical materials for different applications

A Potassium Based Fluorine Containing Bioactive Glass for Use as a Desensitizing Toothpaste

Potassium releasing bioactive glasses (BAGs) may offer improved relief for dentine hypersensitivity compared to conventional sodium containing BAGs by releasing K+ ions for nerve desensitization and occluding dentinal tubules to prevent fluid flow within dentinal tubules. Potassium oxide was substituted for sodium oxide on a molar basis in a fluoride containing BAG used in toothpastes for treating dentine hypersensitivity. The BAG powders were then immersed in an artificial saliva at pH 7 and tris buffer and the pH rise and ion release behavior were characterized by ICP-OES and ISE. The potassium and sodium containing BAGs were characterized by XRD, DSC, FTIR and NMR. Both BAGs presented amorphous diffraction patterns and the glass transition temperature of the potassium glass was higher than that of the sodium glass. The 31P MAS-NMR spectra indicated a peak at 2.7 ppm corresponding to apatite and a small peak at −103 ppm indicated crystallization to fluorapatite. Both BAGs dissolved and formed apatite at similar rates, although the dissolution of the potassium glass was slightly slower and it released less fluoride as a result of partial nanocrystallization to fluorapatite upon quenching. The potassium release from the potassium ions could potentially result in nerve deactivation when used in toothpastes

TECHNOLOGY THREAT AVOIDANCE FACTORS AS PREDICTORS OF RISKY CYBERSECURITY BEHAVIOR WITHIN THE ENTERPRISE

Recent research of information technology (IT) end-user cybersecurity-related risky behaviors has focused on items such as IT user decision-making, impulsiveness, and internet use as predictors of human cyber vulnerability. Theories which guide user human behavioral intent, such as protection motivation theory (PMT, introduced by Rogers, 1975) and technology threat avoidance theory (TTAT, introduced by Liang and Xue, 2009) have not been widely investigated as antecedents of risky cybersecurity behavior (RScB). This dissertation describes exploratory research that analyzed and evaluated PMT/TTAT factors as predictors of RScB by enterprise IT users. This work uniquely contributes to the literature by investigating associations between accepted behavioral motivation models and RScB. Findings are intended to provide human resource development (HRD) practitioners and researchers innovative techniques to identify factors which may compel enterprise IT users to avoid risky cybersecurity behaviors in the workplace. Findings, based on survey responses by 184 working professionals in the United States, were largely consistent with previous TTAT-focused works. New insights arose regarding the predictive impact of perceived cost as a predictor of RScB (p = .003) with small-to-medium effect sizes. Predictability was further leveraged using discriminant analysis to predict RScB category membership derived from k-means clustering. Significant outcomes were noted with practical utility. An overarching goal of this study was to more fully inform the HRD community of scholar-practitioners of the urgent need to design, deliver, implement, and evaluate initiatives that could be utilized to diminish inappropriate and costly cybersecurity behaviors in various workplace environments

The Relationship between both Partial and Complete Denture Wearers and the Presence of Oral Malodour and the Effect of Denture Cleansers on the Oral Microbiota

Oral malodour may be considered a substantial concern for a sizeable percentage of the general population and as such it is important for clinicians to identify the causes of oral malodour, to treat the problem effectively. Aim: The aim of the present study was therefore to review the published literature on the presence and perception of oral malodour (halitosis) in patients wearing both removable partial or complete dentures and the effect of denture cleansers on the oral microbiota. Materials & Methods: A comprehensive electronic search of databases such as PUBMED, Cochrane, Google Scholar, EmBase and Web of Science was performed up to February 2016. Results: 55 potentially relevant reports were identified with six studies included in the review. Of the six included papers, only one study was randomised, and five studies were either non-randomised controlled clinical trials or, quasi randomised trials. The results from these studies would suggest that there was an indirect association between the presence and perception of oral malodour in both RPD and complete denture wearing patients. Conclusions: The strength of evidence was however insufficient to draw any definitive conclusions on a potential correlation of oral malodour in patients with RPDs