Efficacy of a Dissolvable Strip with Calcium Sodium Phosphosilicate (NovaMin®) in Providing Rapid Dentine Hypersensitivity Relief

Objective To evaluate the efficacy of a dissolvable strip containing 15% w/w calcium sodium phosphosilicate (CSPS) (Novamin®) in providing rapid relief from dentine hypersensitivity (DH). Methods In this examiner-blind, proof-of-principle study, 120 healthy adults with DH were randomized 1:1 to the Test strip, professionally applied to facial surfaces of two selected teeth, or to No treatment. Sensitivity was assessed at baseline and 10 min, 2 h and 4 h post-application in response to evaporative (air) and tactile stimuli (measured by Schiff sensitivity scale/a numeric rating scale and tactile threshold, respectively). Change from baseline was analyzed by ANCOVA. Results At 10 min post-application, mean Schiff score change from baseline (primary endpoint) was statistically significant with the Test strip (−0.46; 95% confidence intervals [CI]: −0.563, −0.356; p \u3c 0.0001) but not with No treatment (−0.02; 95% CI: −0.119, 0.088; p = 0.7664). The between-treatment group difference favored the Test strip (difference: −0.44; 95% CI: −0.591, −0.297; p \u3c 0.0001). Similar improvements with the Test strip were reported for all other evaporative (air) and tactile sensitivity endpoints (p \u3c 0.0001 vs no-treatment) at all timepoints (10 min, 2 h, 4 h). Test strips were considered by most staff and participants slightly/moderately easy to apply (98%). Many participants rated the overall usage experience as “like moderately” (40%) or “like extremely” (20%). There were no treatment-related adverse events. Conclusion This new CSPS-based technology may provide a novel treatment option for rapid relief from DH (Clinicaltrials.gov NCT02937623). Clinical significance A dissolvable strip containing 15% w/w calcium sodium phosphosilicate (CSPS) demonstrated significantly greater dentine hypersensitivity reductions following a single application compared with no treatment. Strips were well-liked by participants and generally well tolerated. A strip containing CSPS, which dissolves within 10 min, may provide rapid relief from dentine hypersensitivity

Search for a low mass neutral Higgs boson in Z0 decay

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Search for leptoquarks in Z0^{0} decays

We have searched for direct leptoquark production in Z 0 decays from a scan of the Z 0 resonance, in the energy range 88.2 ≤ √s ≤94.2 GeV, using 5.2 pb -1 of data. We exclude the existence of scalar leptoquarks with masses less than 41 to 44 GeV, depending on the charge assignments, at the 95% confidence level

Search for leptoquarks in Z 0 decays

We have searched for direct leptoquark production in Z 0 decays from a scan of the Z 0 resonance, in the energy range 88.2 ≤ √s ≤94.2 GeV, using 5.2 pb -1 of data. We exclude the existence of scalar leptoquarks with masses less than 41 to 44 GeV, depending on the charge assignments, at the 95% confidence level