Ultrasound Assisted Synthesis of 1,5-Disubstituted Tetrazoles Containing Propargyl or 2-Azidophenyl Moieties via Ugi-Azide Reaction

A series of ten 1,5-disubstituted-1H-tetrazoles (1,5-DS-T) were synthesized via Ugi-azide isocyanide-based multicomponent reactions (IMCR) in low to good yields (30–85%), using propargyl amine or 2-azidobenzaldehyde as a component, and using ultrasound irradiation (USI) as an alternative energy source. 1,5-DS-T are useful heterocyclic moieties, present in many bioactive compounds and drugs. Moreover, 1,5-DS-T are used as bidentate ligands, in coordination chemistry, metal–organic framework science, bioimaging, photo-imaging, explosives, propellants, and high-energy materials. The generated products can be used as synthetic platforms for subsequent post-transformations

Synthesis of novel tetrahydroindeno[1,2-<i>b</i>]pyrrolidines via Ugi multicomponent and palladium-catalyzed aerobic oxidative cyclization

<p>Novel tetrahydroindeno[1,2-<i>b</i>]pyrrolidines were conveniently prepared in moderate to good yields via a sequential Ugi multicomponent reaction or Staudinger/aza-Wittig/Ugi combination, followed by the palladium-catalyzed aerobic oxidative cyclization of the resulting Ugi adducts.</p

Multicomponent Syntheses of Macrocycles

How to access efficiently the macrocyclic structure remained to be a challenging synthetic topic. Although many elegant approaches/reactions have been developed, construction of diverse collection of macrocycles is still elusive. This chapter summarized the recently emerged research area dealing with multicomponent synthesis of macrocycles, with particular emphasis on the approach named “multiple multicomponent reaction using two bifunctional building blocks”