Implications of post-pneumonectomy compensatory lung growth in pulmonary physiology and disease

In a number of species, partial pneumonectomy initiates hormonally regulated compensatory growth of the remaining lung lobes that restores normal mass, structure and function. Compensation is qualitatively similar across species, but differs with gender, age and hormonal status. Although the biology of response is best characterized in rats, dogs have proven valuable in defining post-operative physiological adaptations. Most recently, mice were recognized to offer unique opportunities to explore the genetic basis of the response, as well as to evaluate associated detrimental effects of pathophysiological significance in animals exposed to carcinogens. The pneumonectomy model thus offers powerful insight concerning adaptive organ growth

Quantum Magnetism with Polar Alkali Dimers

We show that dipolar interactions between ultracold polar alkali dimers in optical lattices can be used to realize a highly tunable generalization of the t-J model, which we refer to as the t-J-V-W model. The model features long-range spin-spin interactions J_z and J_perp of XXZ type, long-range density-density interaction V, and long-range density-spin interaction W, all of which can be controlled in both magnitude and sign independently of each other and of the tunneling t. The "spin" is encoded in the rotational degree of freedom of the molecules, while the interactions are controlled by applied static electric and continuous-wave microwave fields. Furthermore, we show that nuclear spins of the molecules can be used to implement an additional (orbital) degree of freedom that is coupled to the original rotational degree of freedom in a tunable way. The presented system is expected to exhibit exotic physics and to provide insights into strongly correlated phenomena in condensed matter systems. Realistic experimental imperfections are discussed.Comment: 24 pages, 8 figure

Family Members\u27 Influence on Family Meal Vegetable Choices

Objective—Characterize the process of family vegetable selection (especially cruciferous, deep orange, and dark green leafy vegetables); demonstrate the usefulness of Exchange Theory (how family norms and past experiences interact with rewards and costs) for interpreting the data. Design—Eight focus groups, two with each segment (men/women vegetable-likers/dislikers based on a screening form). Participants completed a vegetable intake form. Setting—Rural Appalachian Pennsylvania. Participants—61 low-income, married/cohabiting men (n=28) and women (n=33). Analysis—Thematic analysis within Exchange Theory framework for qualitative data. Descriptive analysis, t-tests and chi-square tests for quantitative data. Results—Exchange Theory proved useful for understanding that regardless of sex or vegetable liker/ disliker status, meal preparers see more costs than rewards to serving vegetables. Past experience plus expectations of food preparer role and of deference to family member preferences supported a family norm of serving only vegetables acceptable to everyone. Emphasized vegetables are largely ignored due to unfamiliarity; family norms prevented experimentation and learning through exposure. Conclusions and Implications—Interventions to increase vegetable consumption of this audience could 1) alter family norms about vegetables served, 2) change perceptions of past experiences, 3) reduce social and personal costs of serving vegetables and 4) increase tangible and social rewards of serving vegetables

Possible Stratification Mechanism in Granular Mixtures

We propose a mechanism to explain what occurs when a mixture of grains of different sizes and different shapes (i.e. different repose angles) is poured into a quasi-two-dimensional cell. Specifically, we develop a model that displays spontaneous stratification of the large and small grains in alternating layers. We find that the key requirement for stratification is a difference in the repose angles of the two pure species, a prediction confirmed by experimental findings. We also identify a kink mechanism that appears to describe essential aspects of the dynamics of stratification.Comment: 4 pages, 4 figures, http://polymer.bu.edu/~hmakse/Home.htm

Reduction of fecal coliform levels in two created wetlands at the Olentangy River Wetland Research Park

The University Archives has determined that this item is of continuing value to OSU's history

On the Applicability of Weak-Coupling Results in High Density QCD

Quark matter at asymptotically high baryon chemical potential is in a color superconducting state characterized by a gap Delta. We demonstrate that although present weak-coupling calculations of Delta are formally correct for mu -> Infinity, the contributions which have to this point been neglected are large enough that present results can only be trusted for mu >> mu_c ~ 10^8 MeV. We make this argument by using the gauge dependence of the present calculation as a diagnostic tool. It is known that the present calculation yields a gauge invariant result for mu -> Infinity; we show, however, that the gauge dependence of this result only begins to decrease for mu > mu_c, and conclude that the result can certainly not be trusted for mu < mu_c. In an appendix, we set up the calculation of the influence of the Meissner effect on the magnitude of the gap. This contribution to Delta is, however, much smaller than the neglected contributions whose absence we detect via the resulting gauge dependence.Comment: 21 pages, 3 figures, uses LaTeX2e and ReVTeX, updated figures, made minor text change

Opening the Crystalline Color Superconductivity Window

Cold dense quark matter is in a crystalline color superconducting phase wherever pairing occurs between species of quarks with chemical potentials whose difference \delta\mu lies within an appropriate window. If the interaction between quarks is modeled as point-like, this window is rather narrow. We show that when the interaction between quarks is modeled as single-gluon exchange, the window widens by about a factor of ten at accessible densities and by much larger factors at higher density. This striking enhancement reflects the increasingly (1+1)-dimensional nature of the physics at weaker and weaker coupling. Our results indicate that crystalline color superconductivity is a generic feature of the phase diagram of cold dense quark matter, occurring wherever one finds quark matter which is not in the color-flavor locked phase. If it occurs within the cores of compact stars, a crystalline color superconducting region may provide a new locus for glitch phenomena.Comment: 14 pages, 2 figure

Safety and efficacy of subcutaneous tanezumab in patients with knee or hip osteoarthritis

Background/objective: The objective of this study was to investigate the safety and efficacy of subcutaneous (SC) and intravenous (IV) tanezumab administration in osteoarthritis (OA) patients. Materials and methods: Study 1027 (NCT01089725), a placebo-controlled trial, evaluated the efficacy of SC tanezumab (ie, 2.5, 5, and 10 mg) and the therapeutic equivalence of 10 mg tanezumab given subcutaneously versus intravenously every 8 weeks in the symptomatic treatment of OA. Coprimary endpoints were: change from baseline in Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) Pain and Physical Function indices, and Patient\u27s Global Assessment (PGA) of OA. Study 1043 (NCT00994890) was a long-term, noncontrolled safety study of tanezumab (ie, 2.5, 5, and 10 mg) subcutaneously administered every 8 weeks. Both studies were discontinued prematurely due to a US Food and Drug Administration partial clinical hold. Results: Due to the clinical hold, Study 1027 was underpowered, and no statistical analyses were performed. Mean (standard error [SE]) change from baseline to week 8 in WOMAC Pain in tanezumab groups ranged from -3.59 (0.26) to -3.89 (0.32), versus -2.74 (0.25) with placebo. Mean (SE) change from baseline to week 8 in WOMAC Physical Function ranged from -3.13 (0.25) to -3.51 (0.28) with tanezumab and was -2.26 (0.24) with placebo. PGA mean (SE) change from baseline to week 8 ranged from -0.90 (0.11) to -1.08 (0.12) with tanezumab and was -0.78 (0.10) with placebo. Similar effectiveness was associated with tanezumab in Study 1043. Few patients in either study (1.4%-5.2%) discontinued due to adverse events. Five patients required total joint replacements in Study 1027 (placebo, n=2 [2.8%]; tanezumab 2.5 mg, n=3 [4.1%]) and 34 patients in Study 1043 (tanezumab 2.5 mg, n=11 [4.8%]; tanezumab 5 mg, n=8 [3.6%]; tanezumab 10 mg, n=15 [6.6%]). Conclusion: Preliminary results show similar efficacy and safety for both SC and IV administration of tanezumab based on the direct comparisons reported here and indirect comparisons with published results, confirming pharmacokinetic/pharmacodynamic modeling predictions