Dynamic analysis of MCF-10A and MCF-7: A simulation approach

Cancer is one of the leading causes of death in the world. Breast cancer is the most common form of cancer among women and is responsible for 15 % of all cancer related deaths. Though there are significant advancements in cancer treatment strategies, clinical tumour treatment methods currently employed are often accompanied by severe side effects as they induce damage to the normal cells along with the cancer cells. The alterations in the biophysical and biomechanical properties of a cell as it undergoes transformation from a normal to cancerous cell results in changes in its dynamic characteristics. These changes can be utilised to induce selective cytotoxicity of tumour cells. In the present study, two simulation models (homogenous and non-homogenous) of normal (MCF-10A) and cancerous (MCF-7) breast cells are developed. A finite element approach using Ansys is adopted to investigate the variation in dynamic characteristics of the cells using the two modelling approaches. Results indicate that the natural frequencies of cells modelled as a homogenous system is greater than that of cells whose sub-cellular material properties are considered for analysis. A comparison of the first four natural frequencies using the two modelling approaches for both MCF-10A and MCF-7 cells are illustrated and the corresponding mode shapes reported. A plot highlighting the variation in the natural frequencies of MCF-10A and MCF-7 using the two modelling approaches is presented

Cell dynamics and natural frequencies: scaling and shape matters

Cell dynamics is one of the most investigated areas under the field of biomechanics. Scaling plays a crucial role in determining the dynamic characteristics of biological systems. In the present investigation, cuboidal and cylindrical models of different scales are analysed to depict the dependence of natural frequency on the scaling factors. Three approaches, namely lumped mass system, finite element model (FEM) and numerical approach using Ansys are used to determine the fundamental natural frequencies. Different scaling factors, namely nano, micro (original size), millimeter and meter are considered for the analysis. The results indicate that the natural frequency varies inversely with the size of the cell by the same factor. A simple mathematical relation is derived to support this claim. Results are illustrated with numerical examples and corresponding mode shapes are reported