Futurismo, cultura e politica

Nell’ambito della mostra “Futurismo e Futurismi”, curata da Palazzo Grassi a Venezia nel 1986, la Fondazione Giovanni Agnelli organizzò a Venezia, il 15 e 16 maggio 1986, il convegno “Futurismo, Cultura e Politica”, volto ad esplorare la dimensione politica e meta-politica del movimento e della cultura futurista, in Italia ed all’estero. Il volume raccoglie i saggi nati dalle relazioni presentate in quella occasione.- Indice #5- Introduzione di Renzo De Felice #9- Parte Prima. Gli aspetti generali del rapporto tra futurismo, cultura e politica #13- Futurismo e culture politiche in Europa: una prospettiva globale, George L. Mosse #15- Il ruolo di Marinetti nella costruzione del futurismo, Luciano De Maria #35- Il futurismo nel dibattito intellettuale italiano dalle origini al 1920, Alberto Asor Rosa #51- Futurismo e sinistra politica, Umberto Carpi #69- Macchine e rarimerletti. Alcune fonti del futurismo nell’ideologia e nella letteratura, Roberto Tessari #81- Parte Seconda. L’esperienza politica del futurismo italiano #105- II futurismo e la politica. Dal nazionalismo modernista al fascismo (1909-1920), Emilio Gentile #107- Futurismo e fascismo, Niccolò Zapponi #163- Settimelli e Carli dal futurismo al fascismo, Paolo Buchignani #179- Bottai: da intellettuale futurista a leader fascista, Giordano Bruno Guerri #223- La politica culturale del fascismo, le avanguardie e il problema del futurismo, Enrico Crispolti #249- Parte Terza. Futurismo, cultura e politica fuori d’Italia #287- Futurismo e culture politiche in Francia, Pasquale A. Jannini #289- Futurismo e rivoluzione conservatrice in Germania, Ferruccio Masini #307- Il futurismo italiano e l’avanguardia ungherese, Gianpiero Cavaglià #323- I contatti politico-culturali tra futuristi italiani e Russia, Cesare G. De Michelis #355- Il secondo futurismo russo: la dimensione politica, Halina Stephan #385- Futurismo, ultraismo e culture politiche nell’area ispanica, Jaime Brihuega #411- Futurismo, vorticismo e “mondomoderno”, William C. Wees #443- Interventi #459- Arti liberali e diritto dell’individuo in F. T. Marinetti, Leonardo Clerici #461- Futurismo e dibattito politico, Emilio R. Papa #483- Spettacolo politico e “18 BL”, Marco Verdone #48

Characterising biomolecular interactions and dynamics with mass photometry

We review recent advances in our ability to characterise biomolecular structure, interactions and associated dynamics by mass photometry (MP), the label-free detection and mass measurement of individual biomolecules in solution. Molecular counting and identification provides direct access to relative abundance, and thereby affinities, while associated dynamics yield on- and off-rates. The molecular resolution afforded by MP enables these measurements as a function of stoichiometry and assembly at equilibrium, as opposed to the majority of existing solution-based methods. Together with future improvements in terms of assays and technological performance, MP is likely to provide mechanistic details of complex biomolecular processes

Piazza di Porta S. Giovanni. Riscoperta di un tratto di Mura Aureliane (2013-2015)

L'articolo tratta della riscoperta di un tratto delle Mura Aureliane situato subito ad Ovest di Porta Asinara, nell'ambito di uno scavo per la messa in sicurezza delle Mura durante i lavori per la Metro C di Roma. Lo scavo ha documentato gli interri moderni e contemporanei di piazza S. Giovanni, che obliteravano un utilizzo medievale del circuito difensivo

Biotransformation and oxidative stress responses in relation to tissue contaminant burden in Clarias gariepinus exposed to simulated leachate from a solid waste dumpsite in Calabar, Nigeria

In this study, we have investigated biotransformation and oxidative stress responses in relation to tissue contaminant burden in the African sharptooth catfish (Clarias gariepinus) exposed to simulated leachate from a solid waste dumpsite in Calabar, Nigeria. Fish were exposed to simulated leachate, diluted to 0:0 (negative control), 1:10, 1:50, 1:100 and phenanthrene (a PAH: 50 μg/L used as a positive control) for 3, 7 and 14 days. Hepatic transcripts for cat, sod1, gpx1, gr, gst, cyp1a, cyp2d3, and cyp27 were analyzed by real-time PCR, while enzymatic assays for ethoxyresorufin O-deethylase (EROD), buthoxyresorufin O-deethylase (BROD), methoxyresorufin O-deethylase (MROD), pentoxyresorufin O-deethylase (PROD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST), uridine diphospho-glucuronosyltransferase (UDPGT) and lipid peroxidase (LPO) were measured using standard methods. In addition, protein expression for CYP1A, CYP3A and metallotheionin (MT) were measured by immunoblotting. Fish muscle samples were analyzed for selected group of contaminants after 14 days exposure showing significantly high uptake of heavy metals (Cd, Hg and Pb), polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), chlorophenols, organochlorine (OC) and organophosphate pesticides in exposed fish. We observed significant concentration- and time-specific increases in biotransformation and oxidative stress responses at transcript and functional (enzyme and protein) levels, that paralleled tissue contaminants bioaccumulation patterns, after exposure to the simulated leachates. Our results highlighted the potential environmental, wildlife and public health consequences from improper solid waste disposal. In addition, it also provides a scientific basis for local sensitization and inform legislative decisions and policy formulation towards sustainable environmental management of solid wastes in Nigeria and other developing countries

Sarpi, Paolo

none1Il saggio ricostruisce il percorso biografico, di studio e professionale di Paolo Sarpi sulla base delle acquisizioni della recente storiografia.restrictedBarzazi, AntonellaBarzazi, Antonell

Oligomerization-driven avidity correlates with SARS-CoV-2 cellular binding and inhibition

Cellular processes are controlled by the thermodynamics of the underlying biomolecular interactions. Frequently, structural investigations use one monomeric binding partner, while ensemble measurements of binding affinities generally yield one affinity representative of a 1:1 interaction, despite the majority of the proteome consisting of oligomeric proteins. For example, viral entry and inhibition in SARS-CoV-2 involve a trimeric spike surface protein, a dimeric angiotensin-converting enzyme 2 (ACE2) cell-surface receptor and dimeric antibodies. Here, we reveal that cooperativity correlates with infectivity and inhibition as opposed to 1:1 binding strength. We show that ACE2 oligomerizes spike more strongly for more infectious variants, while exhibiting weaker 1:1 affinity. Furthermore, we find that antibodies use induced oligomerization both as a primary inhibition mechanism and to enhance the effects of receptor-site blocking. Our results suggest that naive affinity measurements are poor predictors of potency, and introduce an antibody-based inhibition mechanism for oligomeric targets. More generally, they point toward a much broader role of induced oligomerization in controlling biomolecular interactions