Incidence, risk factors and mortality of tuberculosis in Danish HIV patients 1995-2007

<p>Abstract</p> <p>Background</p> <p>Human Immunodeficiency Virus (HIV) infection predisposes to tuberculosis (TB). We described incidence, risk factors and prognosis of TB in HIV-1 infected patients during pre (1995-1996), early (1997-1999), and late Highly Active Antiretroviral Therapy (HAART) (2000-2007) periods.</p> <p>Methods</p> <p>We included patients from a population-based, multicenter, nationwide cohort. We calculated incidence rates (IRs) and mortality rates (MRs). Cox's regression analysis was used to estimate risk factors for TB infection with HAART initiation included as time updated variable. Kaplan-Meier was used to estimate mortality after TB.</p> <p>Results</p> <p>Among 2,668 patients identified, 120 patients developed TB during the follow-up period. The overall IR was 8.2 cases of TB/1,000 person-years of follow-up (PYR). IRs decreased during the pre-, early and late-HAART periods (37.1/1000 PYR, 12.9/1000 PYR and 6.5/1000 PYR respectively). African and Asian origin, low CD4 cell count and heterosexual and injection drug user route of HIV transmission were risk factors for TB and start of HAART reduced the risk substantially. The overall MR in TB patients was 34.4 deaths per 1,000 PYR (95% Confidence Interval: 22.0-54.0) and was highest in the first two years after the diagnosis of TB.</p> <p>Conclusions</p> <p>Incidence of TB still associated with conventional risk factors as country of birth, low CD4 count and route of HIV infection while HAART reduces the risk substantially. The mortality in this patient population is high in the first two years after TB diagnosis.</p

Free and Unfree Labor in Atlantic and Indian Ocean Port Cities (Seventeenth–Nineteenth Centuries)

Colonial and postcolonial port cities in the Atlantic and Indian Ocean regions functioned as crucial hubs in the commodity flows that accompanied the emergence and expansion of global capitalism. They did so by bringing together laboring populations of many different backgrounds and statuses-legally free or semi-free wage laborers, soldiers, sailors, and the self-employed, indentured servants, convicts, and slaves. Focusing on the period from the seventeenth to the mid-nineteenth centuries, a crucial moment in the establishment of the world market, the transformation of colonial states, and the reorganization of labor and labor migration on a transoceanic scale, the contributions in this special issue address the consequences of the presence of these motley crews on and around the docks and the neighborhoods that stretched behind them. The introduction places the articles within the context of the development of the field of Global Labor History more generally. It argues that the dense daily interaction that took place in port cities makes them an ideal vantage point from which to investigate the consequences of the simultaneity of different labor relations for questions such as the organization of the work process under developing capitalism, the emergence of new forms of social control, the impact of forced and free migration on class formation, and the role of social diversity in shaping different forms of group and class solidarity. The introduction also discusses the significance of the articles presented in this special issue for three prevailing but problematic dichotomies in labor historiography: The sharp borders drawn between so-called free and unfree labor, between the Atlantic and the Indian oceans, and the pre-modern and modern eras

L'Origine et le parler des Canadiens-Français (publication de la Société du parler français au Canada)

Langlois Ernest. L'Origine et le parler des Canadiens-Français (publication de la Société du parler français au Canada). In: Bibliothèque de l'école des chartes. 1904, tome 65. pp. 621-622

A Precise and Efficient Stereological Method for Determining Murine Lung Metastasis Volumes

We have developed a computer-assisted stereological method based on unbiased principles for estimating metastasis volumes in mouse lungs. We evaluated this method using the transplantable Lewis lung carcinoma. Twenty-one days after subcutaneous inoculation of 106 Lewis lung cells into C57BL/6J mice, the mice had primary tumors with an average volume of 2300 mm3. After perfusion fixation, the lungs were removed, embedded in OCT compound, snap-frozen, and processed for stereology. The metastasis volumes were estimated by application of the Cavalieri principle after evaluation of single sections from several evenly distributed tissue levels. The metastasis volume in a group of nine mice varied between 0.01 and 14.4 mm3, with an average of 6.1 mm3. The coefficient of variation was 0.9. The coefficient of error of the volume estimation was determined in five cases and varied from 0.08 to 0.23. Thus, the variation on the metastasis volumes that is achieved by this method contributes very little, 2.5%, to the total variance within the group of mice. In conclusion, we have developed an efficient and unbiased method to determine the metastasis burden in mouse lungs