Internal conversion coefficients for superheavy elements

The internal conversion coefficients (ICC) were calculated for all atomic subshells of the elements with 104<=Z<=126, the E1...E4, M1...M4 multipolarities and the transition energies between 10 and 1000 keV. The atomic screening was treated in the relativistic Hartree-Fock-Slater model. The Tables comprising almost 90000 subshell and total ICC were recently deposited at LANL preprint server.Comment: 6 pages including 3 figures, needs files myown.sty and epsfig.sty (both included

Absolute Triple Differential Cross Section for Ionization of Helium Near Threshold

Absolute measurements with an accuracy of 22% and theoretical results in a distorted-wave Born approximation (DWBA) are reported for the triple-differential cross section for 26.6-eV electron-impact ionization of helium. An apparatus is used that allows all scattering angles to be independently varied for both coplanar and noncoplanar geometries. The measurements are compared with a DWBA calculation that includes exchange distortion in the calculation of the distorted waves, as well as with earlier calculations by Crothers [J. Phys. B 19, 463 (1986)] and Pan and Starace [Phys. Rev. Lett. 67, 185 (1991)]. Emphasis is placed on understanding the mechanisms for near-threshold ionization

Implications of surface flooding on airborne estimates of snow depth on sea ice

Snow depth observations from airborne snow radars, such as the NASA's Operation IceBridge (OIB) mission, have recently been used in altimeter-derived sea ice thickness estimates, as well as for model parameterization. A number of validation studies comparing airborne and in situ snow depth measurements have been conducted in the western Arctic Ocean, demonstrating the utility of the airborne data. However, there have been no validation studies in the Atlantic sector of the Arctic. Recent observations in this region suggest a significant and predominant shift towards a snow-ice regime caused by deep snow on thin sea ice. During the Norwegian young sea Ice, Climate and Ecosystems (ICE) expedition (N-ICE2015) in the area north of Svalbard, a validation study was conducted on 19 March 2015. This study collected ground truth data during an OIB overflight. Snow and ice thickness measurements were obtained across a two-dimensional (2-D) 400 m × 60 m grid. Additional snow and ice thickness measurements collected in situ from adjacent ice floes helped to place the measurements obtained at the gridded survey field site into a more regional context. Widespread negative freeboards and flooding of the snowpack were observed during the N-ICE2015 expedition due to the general situation of thick snow on relatively thin sea ice. These conditions caused brine wicking into and saturation of the basal snow layers. This causes the airborne radar signal to undergo more diffuse scattering, resulting in the location of the radar main scattering horizon being detected well above the snow–ice interface. This leads to a subsequent underestimation of snow depth; if only radar-based information is used, the average airborne snow depth was 0.16 m thinner than that measured in situ at the 2-D survey field. Regional data within 10 km of the 2-D survey field suggested however a smaller deviation between average airborne and in situ snow depth, a 0.06 m underestimate in snow depth by the airborne radar, which is close to the resolution limit of the OIB snow radar system. Our results also show a broad snow depth distribution, indicating a large spatial variability in snow across the region. Differences between the airborne snow radar and in situ measurements fell within the standard deviation of the in situ data (0.15–0.18 m). Our results suggest that seawater flooding of the snow–ice interface leads to underestimations of snow depth or overestimations of sea ice freeboard measured from radar altimetry, in turn impacting the accuracy of sea ice thickness estimates.</p

Contribution of deformation to sea-ice mass balance: a case study from an N-ICE2015 storm

The fastest and most efficient process of gaining sea ice volume is through the mechanical redistribution of mass as a consequence of deformation events. During the ice growth season divergent motion produces leads where new ice grows thermodynamically, while convergent motion fractures the ice and either piles the resultant ice blocks into ridges or rafts one floe under the other. Here we present an exceptionally detailed airborne dataset from a 9km2 area of first and second year ice in the Transpolar Drift north of Svalbard that allowed us to estimate the redistribution of mass from an observed deformation event. To achieve this level of detail we analyzed changes in sea ice freeboard acquired from two airborne laser scanner surveys just before and right after a deformation event brought on by a passing low pressure system. A linear regression model based on divergence during this storm can explain 64% of freeboard variability. Over the survey region we estimated that about 1.3% of level sea ice volume was pressed together into deformed ice and the new ice formed in leads in a week after the deformation event would increase the sea ice volume by 0.5%. As the region is impacted by about 15 storms each winter a simple linear extrapolation would result in about 7% volume increase and 20% deformed ice fraction at the end of the seaso

On the reliability of the theoretical internal conversion coefficients

Possible sources of uncertainties in the calculations of the internal conversion coefficients are studied. The uncertainties induced by them are estimated.Comment: 16 pages (including 3 figures inserted by 'epsfig' macro

The role of the tissue microenvironment in the regulation of cancer cell motility and invasion

During malignant neoplastic progression the cells undergo genetic and epigenetic cancer-specific alterations that finally lead to a loss of tissue homeostasis and restructuring of the microenvironment. The invasion of cancer cells through connective tissue is a crucial prerequisite for metastasis formation. Although cell invasion is foremost a mechanical process, cancer research has focused largely on gene regulation and signaling that underlie uncontrolled cell growth. More recently, the genes and signals involved in the invasion and transendothelial migration of cancer cells, such as the role of adhesion molecules and matrix degrading enzymes, have become the focus of research. In this review we discuss how the structural and biomechanical properties of extracellular matrix and surrounding cells such as endothelial cells influence cancer cell motility and invasion. We conclude that the microenvironment is a critical determinant of the migration strategy and the efficiency of cancer cell invasion

Sea-ice-free Arctic during the Last Interglacial supports fast future loss

The Last Interglacial (LIG), a warmer period 130-116 ka before present, is a potential analog for future climate change. Stronger LIG summertime insolation at high northern latitudes drove Arctic land summer temperatures 4-5 °C higher than the preindustrial era. Climate model simulations have previously failed to capture these elevated temperatures, possibly because they were unable to correctly capture LIG sea-ice changes. Here, we show the latest version of the fully-coupled UK Hadley Center climate model (HadGEM3) simulates a more accurate Arctic LIG climate, including elevated temperatures. Improved model physics, including a sophisticated sea-ice melt-pond scheme, result in a complete simulated loss of Arctic sea ice in summer during the LIG, which has yet to be simulated in past generations of models. This ice-free Arctic yields a compelling solution to the longstanding puzzle of what drove LIG Arctic warmth and supports a fast retreat of future Arctic summer sea ice

DEAD-Box Protein Ddx46 Is Required for the Development of the Digestive Organs and Brain in Zebrafish

Spatially and temporally controlled gene expression, including transcription, several mRNA processing steps, and the export of mature mRNA to the cytoplasm, is essential for developmental processes. It is well known that RNA helicases of the DExD/H-box protein family are involved in these gene expression processes, including transcription, pre-mRNA splicing, and rRNA biogenesis. Although one DExD/H-box protein, Prp5, a homologue of vertebrate Ddx46, has been shown to play important roles in pre-mRNA splicing in yeast, the in vivo function of Ddx46 remains to be fully elucidated in metazoans. In this study, we isolated zebrafish morendo (mor), a mutant that shows developmental defects in the digestive organs and brain, and found that it encodes Ddx46. The Ddx46 transcript is maternally supplied, and as development proceeds in zebrafish larvae, its ubiquitous expression gradually becomes restricted to those organs. The results of whole-mount in situ hybridization showed that the expression of various molecular markers in these organs is considerably reduced in the Ddx46 mutant. Furthermore, splicing status analysis with RT-PCR revealed unspliced forms of mRNAs in the digestive organ and brain tissues of the Ddx46 mutant, suggesting that Ddx46 may be required for pre-mRNA splicing during zebrafish development. Therefore, our results suggest a model in which zebrafish Ddx46 is required for the development of the digestive organs and brain, possibly through the control of pre-mRNA splicing

C4.4A as a candidate marker in the diagnosis of colorectal cancer

C4.4A is a member of the Ly-6 family with restricted expression in non-transformed tissues. C4.4A expression in human cancer has rarely been evaluated. Thus, it became important to explore C4.4A protein expression in human tumour tissue to obtain an estimate on the frequency of expression and the correlation with tumour progression, the study focusing on colorectal cancer. The analysis of C4.4A in human tumour lines by western blot and immunoprecipitation using polyclonal rabbit antibodies that recognize different C4.4A epitopes revealed C4.4A oligomer and heavily glycosylated C4.4A isoform expression that, in some instances, inhibited antibody binding and interaction with the C4.4A ligand galectin-3. In addition, tumour cell lines released C4.4A by vesicle shedding and proteolytic cleavage. C4.4A was expressed in over 80% of primary colorectal cancer and liver metastasis with negligible expression in adjacent colonic mucosa, inflamed colonic tissue and liver. This compares well with EpCAM and CO-029 expression in over 90% of colorectal cancer. C4.4A expression was only observed in about 50% of pancreatic cancer and renal cell carcinoma. By de novo expression in colonic cancer tissue, we consider C4.4A as a candidate diagnostic marker in colorectal cancer, which possibly can be detected in body fluids