Investigating social dominance in a prison population

This study using a prison sample to explore Social Dominance Orientation (SDO), socially dominant inmate behaviour, index offence, age and length of time served in secure environments. A sample of 397 adult male prisoners completed the Direct and Indirect Prisoner Behaviour Checklist- Scaled (prisoner behaviour towards other inmates and staff) and the Social Dominance Orientation (SDO) Scale. It was predicted that prisoners would report higher SDO than non-incarcerated populations and that among inmates those with approach orientated index offences would be higher in SDO than those whose offenses were more remote. It was also predicted that SDO would be related to younger age, higher lifetime rates of incarceration, more negative behaviour towards other inmates and staff, and more resource focused behaviour. The results broadly supported predictions, and possible implications for practice and directions for future research are discussed

Pseudovirus rVSVΔG-ZEBOV-GP Infects Neurons in Retina and CNS, Causing Apoptosis and Neurodegeneration in Neonatal Mice

Summary: Zaire Ebola virus (ZEBOV) survivors experience visual and CNS sequelae that suggests the ZEBOV glycoprotein can mediate neurotropism. Replication-competent rVSVΔG-ZEBOV-GP vaccine candidate is generally well tolerated; however, its potential neurotropism requires careful study. Here, we show that a single inoculation of rVSVΔG-ZEBOV-GP virus in neonatal C57BL/6 mice results in transient viremia, neurological symptoms, high viral titers in eyes and brains, and death. rVSVΔG-ZEBOV-GP infects the inner layers of the retina, causing severe retinitis. In the cerebellum, rVSVΔG-ZEBOV-GP infects neurons in the granular and Purkinje layers, resulting in progressive foci of apoptosis and neurodegeneration. The susceptibility to infection is not due to impaired type I IFN responses, although MDA5−/−, IFNβ−/−, and IFNAR1−/− mice have accelerated mortality. However, boosting interferon levels by co-administering poly(I:C) reduces viral titers in CNS and improves survival. Although these data should not be directly extrapolated to humans, they challenge the hypothesis that VSV-based vaccines are non-neurotropic. : Survivors of Ebola infections can experience neurologic and ocular symptoms, raising some concern that replication-competent vaccines expressing Ebola components could infect neurons in susceptible subjects. McWilliams et al. show that the rVSVΔG-EBOV-GP pseudovirus infects neurons in the eyes and brains of neonatal mice, causing tissue damage and lethality. Keywords: Ebola virus, ebolavirus, filovirus, Ebola glycoprotein, VSV, pseudotyped virus, VSV vaccine, innate immunity, neurotropism, neurovirulence, Ebola vaccin