8 research outputs found
Respiratory Syncytial Virus and Other Viral Infections among Children under Two Years Old in Southern Vietnam 2009-2010: Clinical Characteristics and Disease Severity
<div><p>Background</p><p>Despite a high burden of respiratory syncytial virus (RSV) infections among children, data on demographic and clinical characteristics of RSV are scarce in low and middle income countries. This study aims to describe the viral etiologies, the demographic, epidemiological, and clinical characteristics of children under two years of age who were hospitalized with a lower respiratory tract infections (LRTI), focusing on RSV (prevalence, seasonality, subgroups, viral load) and its association with disease severity.</p><p>Methods</p><p>A prospective study among children under two years of age, hospitalized with LRTI was conducted in two referral pediatric hospitals in Ho Chi Minh City, Vietnam, from May 2009 to December 2010. Socio-demographic, clinical data and nasopharyngeal swabs were collected on enrolment and discharge. Multiplex real-time RT-PCR (13 viruses) and quantitative RSV RT-PCR were used to identify viral pathogens, RSV load and subgroups.</p><p>Results</p><p>Among 632 cases, 48% were RSV positive. RSV infections occurred at younger age than three other leading viral infections i.e rhinovirus (RV), metapneumovirus (MPV), parainfluenza virus (PIV-3) and were significantly more frequent in the first 6 months of life. Clinical severity score of RSV infection was significantly higher than PIV-3 but not for RV or MPV. In multivariate analysis, RV infection was significantly associated with severity while RSV infection was not. Among RSV infections, neither viral load nor viral co-infections were significantly associated with severity. Young age and having fever at admission were significantly associated with both RSV and LRTI severity. A shift in RSV subgroup predominance was observed during two consecutive rainy seasons but was not associated with severity.</p><p>Conclusion</p><p>We report etiologies, the epidemiological and clinical characteristics of LRTI among hospitalized children under two years of age and risk factors of RSV and LRTI severity.</p></div
Viral single and co-infections among all enrolled patients.
<p>Viral single and co-infections among all enrolled patients.</p
Comparison of demographic and clinical characteristics among patients with RSV, RV, MPV and PIV-3.
<p>Comparison of demographic and clinical characteristics among patients with RSV, RV, MPV and PIV-3.</p
Factors independently predicting disease severity or long hospitalization among LRTI hospitalized children and among RSV-infected children.
<p>Factors independently predicting disease severity or long hospitalization among LRTI hospitalized children and among RSV-infected children.</p
Number of cases enrolled and total numbers of LRTI children hospitalized in two referral pediatric hospitals in southern Vietnam, May 2009 to December 2010.
<p>A total of 106/632 (17%)of cases met at least one clinical criterion for severe disease, and 43% (271/632) were hospitalized for >7 days. Among the children requiring supplemental oxygen or ventilatory support, 16/93 (17%) received NCPAP, 2/93 (2%) were intubated.</p
Clinical score index<sup>*</sup>.
<p>Clinical score index<sup><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0160606#t001fn001" target="_blank">*</a></sup>.</p
RSV, RSV subgroups, other viruses and severe cases distribution.
<p>RSV, RSV subgroups, other viruses and severe cases distribution.</p