Convergence analysis of a Crank-Nicolson Galerkin method for an inverse source problem for parabolic equations with boundary observations

This work is devoted to an inverse problem of identifying a source term depending on both spatial and time variables in a parabolic equation from single Cauchy data on a part of the boundary. A Crank-Nicolson Galerkin method is applied to the least squares functional with an quadratic stabilizing penalty term. The convergence of finite dimensional regularized approximations to the sought source as measurement noise levels and mesh sizes approach to zero with an appropriate regularization parameter is proved. Moreover, under a suitable source condition, an error bound and corresponding convergence rates are proved. Finally, several numerical experiments are presented to illustrate the theoretical findings.Comment: Inverse source problem, Tikhonov regularization, Crank-Nicolson Galerkin method, Source condition, Convergence rates, Ill-posedness, Parabolic proble

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead