Use of rare earth oxides as tracers to identify sediment source areas for agricultural hillslopes

Understanding sediment sources is essential to enable more effective targeting of in-field mitigation approaches to reduce diffuse pollution from agricultural land. In this paper we report on the application of rare earth element oxides to arable soils at hillslope scale in order to determine sediment source areas and their relative importance, using a non-intrusive method of surface spraying. Runoff, sediments and rare earth elements lost from four arable hillslope lengths at a site in the UK with clay soils were monitored from three rainfall events after tracer application. Measured erosion rates were low, reflecting the typical event conditions occurring at the site, and less than 1% of the applied REO tracers were recovered, which is consistent with the results of comparable studies. Tracer recovery at the base of the hillslope was able to indicate the relative importance of different hillslope sediment source areas, which were found to be consistent between events. The principal source of eroded sediments was the upslope area, implying that the wheel tracks were principally conduits for sediment transport, and not highly active sites of erosion. Mitigation treatments for sediment losses from arable hillslopes should therefore focus on methodologies for trapping mobile sediments within wheel track areas through increasing surface roughness or reducing the connectivity of sediment transport processes

Effects of piperaquine, chloroquine, and amodiaquine on drug uptake and of these in combination with dihydroartemisinin against drug-sensitive and -resistant Plasmodium falciparum strains.

Piperaquine is being developed as a long-acting component in artemisinin combination therapies. It was highly active in vitro and drug interaction studies showed that dihydroartemisinin combinations with piperaquine, chloroquine, and amodiaquine were indifferent tending toward antagonism. Competitive uptake of radiolabeled chloroquine and dihydroartemisinin in combination with other antimalarials was observed

Design of a Purlin System

This paper is concerned with the design of cold-formed steel structural members which span between the frames of a building and carry cladding which is usually either single- or double-skin profiled metal sheeting or a sandwich panel. The cladding is fIxed to these purlins or sheeting rails at regular intervals and the performance in service, and therefore the design, is strongly influenced by interaction with the sheeting. The connection between the purlins and the supporting structure also has a significant influence on performance so that, historically, the emphasis has tended to be on empirical methods of design rather than detailed calculations of the structural behaviour. In a previous paper[1], the fIrst author described the design of a purlin system, known as Multibeam Mark 2, based on a cold-formed steel Sigma profile. The alternative approaches to design were reviewed and a semi-empirical design procedure was described which resulted in safe but competitive load-span tables. This paper describes the design of Multibeam Mark 3. This involves a further evolution of the cross-section together with further improvement of the design procedure. The tendency is to continue to move away from reliance on testing and towards an approach which is much more orientated towards design by calculation, a trend which is becoming increasingly necessary in view of the proliferation of different cladding types, all offering different degrees of restraint to the purlin. It is shown that, in the present state-of-the-art, a design procedure based entirely on calculation, while taking into account such practical factors as restraint from alternative cladding systems and distortion and partial plasticity at internal supports, is now feasible. However, as the profession may not yet be ready for such a radical approach, the design procedure used for Multibeam Mark 3 is backed up by a comprehensive test programme

Investigating source areas of eroded sediments transported in concentrated overland flow using rare earth element tracers

Rare earth element oxides (REOs) have excellent potential for use as tracers in erosion studies. Using laboratory and field experiments we aimed to develop and test a simple application method for spreading REOs and to use REOs to determine the source of sediment to concentrated overland flow paths. Tracks left by farm machinery (tramlines) in fields act as concentrated flow paths, delivering a large amount of surface runoff and entrained sediment to the field boundary however little is known regarding where this sediment is sourced from. Two field experiments were conducted to investigate this, one looking at whether sediment is entrained from different points along the length of the tramline and one looking at the area over which sediment is entrained from either side of a tramline. Results from leaching tests and rainfall simulations clearly demonstrated the potential of this method for tracing sediment, there was very little movement of REOs through the soil profile and they were transported with sediment in overland flow. In the field experiment a large proportion of the sediment transported in the tramline originated within the first metre either side of it. However, the total area over which eroded sediment collects and flows into the tramline is potentially large with small amounts of sediment eroded from the between 4 and 6 m being transported in the tramline. REOs have an excellent potential for use as a tracer of soil erosion. They provide a quick and cheap method of identifying sources of eroded sediments and have good potential for use in determining erosion rates

An unusual suicidal death by automobile antenna: a case report

Worldwide, over one million people commit suicide every year. In the United States, the majority of these cases consist of gunshot wounds, hangings, and drug overdoses. Nevertheless, on rare occasions will individuals exhibit extraordinary creativity in how they decide to end their lives

How does an external electrical field affect adsorption patterns of thiol and thiolate on the gold substrate ?

The responsive behavior of methanethiol and methylthiolate molecules on the Au(111) surface with an applied electrical potential is studied, and it is shown how the sulfur adsorption site, the S-H bond orientation and the interacting energy change with an external electric field strength. The electron charge density corresponding to an electric field minus that obtained in zero field, with zero-field optimal geometry, is calculated to explain the responsive behavior. The interacting energy for the intact methanethiol adsorption is larger than that for the dissociative one, showing that an external electric field can not make the hydrogen dissociate from the sulfur.Comment: 11 pages, 3 figures, LaTe

Epithelial cell–derived secreted and transmembrane 1a signals to activated neutrophils during pneumococcal pneumonia

Airway epithelial cell responses are critical to the outcome of lung infection. In this study, we aimed to identify unique contributions of epithelial cells during lung infection. To differentiate genes induced selectively in epithelial cells during pneumonia, we compared genome-wide expression profiles from three sorted cell populations: epithelial cells from uninfected mouse lungs, epithelial cells from mouse lungs with pneumococcal pneumonia, and nonepithelial cells from those same infected lungs. Of 1,166 transcripts that were more abundant in epithelial cells from infected lungs compared with nonepithelial cells from the same lungs or from epithelial cells of uninfected lungs, 32 genes were identified as highly expressed secreted products. Especially strong signals included two related secreted and transmembrane (Sectm) 1 genes, Sectm1a and Sectm1b. Refinement of sorting strategies suggested that both Sectm1 products were induced predominantly in conducting airway epithelial cells. Sectm1 was induced during the early stages of pneumococcal pneumonia, and mutation of NF-kB RelA in epithelial cells did not diminish its expression. Instead, type I IFN signaling was necessary and sufficient for Sectm1 induction in lung epithelial cells, mediated by signal transducer and activator of transcription 1. For target cells, Sectm1a bound to myeloid cells preferentially, in particular Ly6GbrightCD11bbright neutrophils in the infected lung. In contrast, Sectm1a did not bind to neutrophils from uninfected lungs. Sectm1a increased expression of the neutrophil-attracting chemokine CXCL2 by neutrophils from the infected lung. We propose that Sectm1a is an epithelial product that sustains a positive feedback loop amplifying neutrophilic inflammation during pneumococcal pneumonia