Light to Mass Variations with Environment

Large and well defined variations exist between the distribution of mass and the light of stars on extragalactic scales. Mass concentrations in the range 10^12 - 10^13 M_sun manifest the most light per unit mass. Group halos in this range are typically the hosts of spiral and irregular galaxies with ongoing star formation. On average M/L_B ~ 90 M_sun/L_sun in these groups . More massive halos have less light per unit mass. Within a given mass range, halos that are dynamically old as measured by crossing times and galaxy morphologies have distinctly less light per unit mass. At the other end of the mass spectrum, below 10^12 M_sun, there is a cutoff in the manifestation of light. Group halos in the range 10^11 - 10^12 M_sun can host dwarf galaxies but with such low luminosities that M/L_B values can range from several hundred to several thousand. It is suspected that there must be completely dark halos at lower masses. Given the form of the halo mass function, it is the low relative luminosities of the high mass halos that has the greatest cosmological implications. Of order half the clustered mass may reside in halos with greater than 10^14 M_sun. By contrast, only 5-10% of clustered mass would lie in entities with less than 10^12 M_sun.Comment: 15 pages, 9 figures, 2 tables, Accepted Astrophysical Journal 619, 000, 2005 (Jan 1

An Inversion Disrupting FAM134B Is Associated with Sensory Neuropathy in the Border Collie Dog Breed

Sensory neuropathy in the Border Collie is a severe neurological disorder caused by the degeneration of sensory and, to a lesser extent, motor nerve cells with clinical signs starting between 2 and 7 months of age. Using a genome-wide association study approach with three cases and 170 breed matched controls, a suggestive locus for sensory neuropathy was identified that was followed up using a genome sequencing approach. An inversion disrupting the candidate gene FAM134B was identified. Genotyping of additional cases and controls and RNAseq analysis provided strong evidence that the inversion is causal. Evidence of cryptic splicing resulting in novel exon transcription for FAM134B was identified by RNAseq experiments. This investigation demonstrates the identification of a novel sensory neuropathy associated mutation, by mapping using a minimal set of cases and subsequent genome sequencing. Through mutation screening, it should be possible to reduce the frequency of or completely eliminate this debilitating condition from the Border Collie breed population

The RASSCALS: An X-ray and Optical Study of 260 Galaxy Groups

We describe the ROSAT All-Sky Survey-Center for Astrophysics Loose Systems (RASSCALS), the largest X-ray and optical survey of low mass galaxy groups to date. We draw 260 groups from the combined Center for Astrophysics and Southern Sky Redshift Surveys, covering one quarter of the sky to a limiting Zwicky magnitude of 15.5. We detect 61 groups (23%) as extended X-ray sources. The statistical completeness of the sample allows us to make the first measurement of the X-ray selection function of groups, along with a clean determination of their fundamental scaling laws. We find robust evidence of similarity breaking in the relationship between the X-ray luminosity and velocity dispersion. Groups with sigma < 340 km/s are overluminous by several orders of magnitude compared to the familiar LX ~ sigma^4 law for higher velocity dispersion systems. An understanding of this break depends on the detailed structure of groups with small velocity dispersions sigma < 150 km/s.Comment: 16 pages, including 6 figures. To appear in The Astrophysical Journa

A Richness Study of 14 Distant X-ray Clusters From the 160 Square Degree Survey

We have measured the surface density of galaxies toward 14 X-ray-selected cluster candidates at redshifts greater than z=0.46, and we show that they are associated with rich galaxy concentrations. We find that the clusters range between Abell richness classes 0-2, and have a most probable richness class of one. We compare the richness distribution of our distant clusters to those for three samples of nearby clusters with similar X-ray luminosities. We find that the nearby and distant samples have similar richness distributions, which shows that clusters have apparently not evolved substantially in richness since redshift z =0.5. We compare the distribution of distant X-ray clusters in the L_x--richness plane to the distribution of optically-selected clusters from the Palomar Distant Cluster Survey. The optically-selected clusters appear overly rich for their X-ray luminosities when compared to X-ray-selected clusters. Apparently, X-ray and optical surveys do not necessarily sample identical mass concentrations at large redshifts. This may indicate the existence of a population of optically rich clusters with anomalously low X-ray emission. More likely, however, it reflects the tendency for optical surveys to select unvirialized mass concentrations, as might be expected when peering along large-scale filaments.Comment: The abstract has been abridged. Accepted for publication in the Astrophysical Journa

El agronegocio del cultivo de tartago em el mundo.

bitstream/CNPA/18351/1/CIRTEC101.pd

Acid-sensing ion channel 1a drives AMPA receptor plasticity following ischemia and acidosis in hippocampal CA1 neurons

The CA1 region of the hippocampus is particularly vulnerable to ischemic damage. While NMDA receptors play a major role in excitotoxicity, it is thought to be exacerbated in this region by two forms of post-ischemic AMPA receptor (AMPAR) plasticity - namely, anoxic long-term potentiation (a-LTP), and a delayed increase in the prevalence of Ca2+ -permeable GluA2-lacking AMPARs (CP-AMPARs). The acid-sensing ion channel 1a (ASIC1a) which is expressed in CA1 pyramidal neurons, is also known to contribute to post-ischemic neuronal death and to physiologically induced LTP. This raises the question - does ASIC1a activation drive the post-ischemic forms of AMPAR plasticity in CA1 pyramidal neurons? We have tested this by examining organotypic hippocampal slice cultures (OHSCs) exposed to oxygen glucose deprivation (OGD), and dissociated cultures of hippocampal pyramidal neurons (HPN) exposed to low pH (acidosis). We find that both a-LTP and the delayed increase in the prevalence of CP-AMPARs are dependent on ASIC1a activation during ischemia. Indeed, acidosis alone is sufficient to induce the increase in CP-AMPARs. We also find that inhibition of ASIC1a channels circumvents any potential neuroprotective benefit arising from block of CP-AMPARs. By demonstrating that ASIC1a activation contributes to post-ischemic AMPAR plasticity, our results identify a functional interaction between acidotoxicity and excitotoxicity in hippocampal CA1 cells, and provide insight into the role of ASIC1a and CP-AMPARs as potential drug targets for neuroprotection. We thus propose that ASIC1a activation can drive certain forms of CP-AMPAR plasticity, and that inhibiting ASIC1a affords neuroprotection

Intra-Arterial Blood Pressure Characteristics during Submaximal Cycling and Recovery

The purpose of this study was to measure intra-arterial (IA) blood pressure from rest to steady-state submaximal exercise and immediately post-exercise. Beat-to-beat blood pressure was compared to breath-by-breath VO2 during steady-state and maximal exercise. Fourteen normotensive subjects volunteered. Systolic (SBP), diastolic (DBP) and mean (mBP) blood pressure was measured from rest to steady state during cycling at 45, 60, and 75% maximal power output (POmax). BP was assessed during recovery from VO2peak through 2 min of cycling at 50 W. During the rest to exercise transition, mBP decreased from 103.41 ± 9.4 to 90.1 ± 8.9 mmHg after 11.6 ± 6.2 s (