The Engineering Hubs and Spokes Project - institutional cooperation in educational design and delivery

The emergence of blended learning techniques that embrace a combination of face-to-face and online learning environments offers a raft of opportunity for flexibility in education. While much writing has focused on the opportunities for flexibility for the students and teachers, this paper focuses on the opportunities for effective sharing of expertise and effort between institutions. The Engineering 'Hubs and Spokes' project is a collaboration between The Australian National University and the University of South Australia. It draws on the strengths of each to improve the range and quality of educational opportunities for students. Two components of the project are underpinned by blended teaching and learning techniques: sharing of courses at the advanced undergraduate level; and development of an integrated graduate development program. We describe choices made, benefits identified, and the challenges encountered in the early stages of the project. We discuss recommendations for the future of cooperation in educational design and delivery, and comment on the opportunities that arise for structural reform of the higher education sector

Occurrence and Ecosystem Effects of Hiking Off-Trail in Michaux State Forest

American public lands provide significant outdoor recreational opportunities that enhance an individual\u27s physical and mental well-being. Hiking is an example of a highly accessible and affordable recreational activity that is popular and easy for people to engage in no matter how experienced they are. While hiking has improved the well-being of many individuals, its impacts on local ecosystems are often disregarded. For our research, we focused on the impacts that hikers deviating off-trail may have on a local ecosystem in Michaux State Forest in Southern Pennsylvania. Through partnering with the foresters at Michaux State Forest and using AllTrails data, we identified heavily trafficked, unmaintained trail areas and conducted numerous field visits to observe the ecological impacts of this continued off-trail use. At each of the sites, we set up trail cameras in order to measure trail traffic, measured trail dimensions at numerous locations, and used quadrats to examine noticeable impacts on ground cover and plant ecology. We found substantial off-trail use at Michaux State Forest, from legal trail “shortcuts” to fully illegal trails. Surprisingly, we found no evidence that off-trail use impacted overall vegetative cover. In all of the study sites, the official trail was wider than the beginning of the illegal trail area and the beginning of the illegal trail was wider than the trail at the placement of the trail camera. For future analysis, we recommend that soil analyses and longer data collection periods potentially through different seasons should be conducted, as our quadrat photos and physical observations were limited due to the leafy ground cover. Our recommendations for future management include increased signage intended to prevent off-trail travel as well as improved hiker education on the principles of Leave No Trace

Blinded patient preference for morphine compared to placebo in the setting of chronic refractory breathlessness – an exploratory study

Context Patients’ preference for morphine therapy has received little attention in the setting of chronic refractory breathlessness. However, this is one important factor in considering longer term therapy. Objectives The aim of this secondary analysis is to explore blinded patient preference of morphine compared to placebo for this indication and to define any predictors of preference. Methods Data were pooled from three randomized, double-blind, crossover, placebo-controlled studies of morphine (four days each) in chronic refractory breathlessness. Blinded patient preferences were chosen at the end of each study. A multivariable regression model was used to establish patient predictors of preference. Results Sixty-five participants provided sufficient data (60 males; median age 74 years; heart failure 55%, chronic obstructive pulmonary disease 45%; median Eastern Cooperative Oncology Group performance status 2). Forty-three percent of participants preferred morphine (32% placebo and 25% no preference). Morphine preference and younger age were strongly associated: odds ratio = 0.85, 95% confidence interval 0.78, 0.93;

Characterisation of multiple regulatory domains spanning the major transcriptional start site of the FUS gene, a candidate gene for motor neurone disease

Fused-In-Sarcoma (FUS) is a candidate gene for neurological disorders including motor neurone disease and Parkinson’s disease in addition to various types of cancer. Recently it has been reported that over expression of FUS causes motor neurone disease in mouse models hence mutations leading to changes in gene expression may contribute to the development of neurodegenerative disease. Genome evolutionary conservation was used to predict important cis-acting DNA regulators of the FUS gene promoter that direct transcription. The putative regulators identified were analysed in reporter gene assays in cells and in chick embryos. Our analysis indicated in addition to regulatory domains 5’ of the transcriptional start site an important regulatory domain resides in intron 1 of the gene itself. This intronic domain functioned both in cell lines and in vivo in the neural tube of the chick embryo including developing motor neurones. Our data suggests the interaction of multiple domains including intronic domains are involved in expression of FUS. A better understanding of the regulation of expression of FUS may give insight into how its stimulus inducible expression may be associated with neurological disorders

How Old We Are & How Old We Feel

Many researchers assess differences in age as a distinct independent variable for a wide range of empirical analyses. However, subjective age (how old people feel) is a construct that has been relatively neglected in the literature. The purpose of the current study was to assess the relationship between chronological age and subjective age, as well as subjective age differences between genders. As part of a larger study, 95 participants completed the Subjective Age Questionnaire (Montepare, Rierdan, Koff, & Stubbs, 1989) including 5 items on a 7-point Likert scale. Reported subjective age was subtracted by chronological age (age discrepancy) for comparison between genders. A significant negative correlation emerged, such that as chronological age increased, subjective age scores subsequently decreased. A comparison of mean age discrepancy scores between genders revealed a difference that was marginally significant, with males reporting a subjective age slightly younger than their actual age, and females reporting subjective age slightly older than their actual age

Astro2020 Science White Paper: Toward Finding Earth 2.0: Masses and Orbits of Small Planets with Extreme Radial Velocity Precision

Having discovered that Earth-sized planets are common, we are now embarking on a journey to determine if Earth-like planets are also common. Finding Earth-like planets is one of the most compelling endeavors of the 21st century - leading us toward finally answering the question: Are we alone? To achieve this forward-looking goal, we must determine the masses of the planets; the sizes of the planets, by themselves, are not sufficient for the determination of the bulk and atmospheric compositions. Masses, coupled with the radii, are crucial constraints on the bulk composition and interior structure of the planets and the composition of their atmospheres, including the search for biosignatures. Precision radial velocity is the most viable technique for providing essential mass and orbit information for spectroscopy of other Earths. The development of high quality precision radial velocity instruments coupled to the building of the large telescope facilities like TMT and GMT or space-based platforms like EarthFinder can enable very high spectral resolution observations with extremely precise radial velocities on minute timescales to allow for the modeling and removal of radial velocity jitter. Over the next decade, the legacy of exoplanet astrophysics can be cemented firmly as part of humankind's quest in finding the next Earth - but only if we can measure the masses and orbits of Earth-sized planets in habitable zone orbits around Sun-like stars.Comment: Science White Paper Submitted to the Astro2020 Decadal Survey (35 co-signers in addition to co-authors

New Frontiers for Terrestrial-sized to Neptune-sized Exoplanets In the Era of Extremely Large Telescopes

Surveys reveal that terrestrial- to Neptune-sized planets (1 $< R <$ 4 R$_{\rm{Earth}}$) are the most common type of planets in our galaxy. Detecting and characterizing such small planets around nearby stars holds the key to understanding the diversity of exoplanets and will ultimately address the ubiquitousness of life in the universe. The following fundamental questions will drive research in the next decade and beyond: (1) how common are terrestrial to Neptune-sized planets within a few AU of their host star, as a function of stellar mass? (2) How does planet composition depend on planet mass, orbital radius, and host star properties? (3) What are the energy budgets, atmospheric dynamics, and climates of the nearest worlds? Addressing these questions requires: a) diffraction-limited spatial resolution; b) stability and achievable contrast delivered by adaptive optics; and c) the light-gathering power of extremely large telescopes (ELTs), as well as multi-wavelength observations and all-sky coverage enabled by a comprehensive US ELT Program. Here we provide an overview of the challenge, and promise of success, in detecting and comprehensively characterizing small worlds around the very nearest stars to the Sun with ELTs. This white paper extends and complements the material presented in the findings and recommendations published in the National Academy reports on Exoplanet Science Strategy and Astrobiology Strategy for the Search for Life in the Universe.Comment: Astro2020 Science White Pape

Translating drug resistant tuberculosis treatment guidelines to reality in war-torn Kandahar, Afghanistan: a retrospective cohort study

Introduction Afghanistan is affected by one of the world’s longest protracted armed conflicts, frequent natural disasters, disease outbreaks and large population movements and it suffers from a high burden of tuberculosis (TB), including rifampicin-resistant TB (RR-TB). The study shows Médecins Sans Frontières’ experiences with care for patients with RR-TB in Kandahar Province. We describe the uptake of RR-TB treatment, how World Health Organisation criteria for the choice between the short and an individualized regimen were implemented, and treatment outcomes. Methods This is a retrospective cohort analysis of routinely collected data from RR-TB patients enrolled in care from 2016 until 2019. Descriptive analysis was performed to present characteristics of patients and treatment outcomes. Multivariable Cox analysis was performed to identify risk factors for having an unfavourable treatment outcome. Results Out of 146 enrolled RR-TB patients, 112 (76.7%) started treatment: 41 (36.6%) and 71 (63.4%) with the short and individualized treatment regimen, respectively. Of 82 with results for fluoroquinolone susceptibility, 39 (47.6%) had fluoroquinolone-resistant TB. Seven patients with initially fluoroquinolone-resistant TB and three pregnant women started the short regimen and 18 patients eligible for the short regimen started the injectable-free individualized regimen. Overall, six-month smear and culture conversion were 98.7% and 97.1%, respectively; treatment success was 70.1%. Known initial fluoroquinolone resistance (aHR 3.77, 95%CI:1.53–9.27) but not choice of regimen predicted having an unfavourable outcome. Conclusion Even though criteria for the choice of treatment regimen were not applied strictly, we have achieved acceptable outcomes in this cohort. To expand RR-TB care, treatment regimens should fit provision at primary health care level and take patient preferences into account

TESS Discovery of an ultra-short-period planet around the nearby M dwarf LHS 3844

Data from the newly-commissioned \textit{Transiting Exoplanet Survey Satellite} (TESS) has revealed a "hot Earth" around LHS 3844, an M dwarf located 15 pc away. The planet has a radius of $1.32\pm 0.02$ $R_\oplus$ and orbits the star every 11 hours. Although the existence of an atmosphere around such a strongly irradiated planet is questionable, the star is bright enough ($I=11.9$, $K=9.1$) for this possibility to be investigated with transit and occultation spectroscopy. The star's brightness and the planet's short period will also facilitate the measurement of the planet's mass through Doppler spectroscopy.Comment: 10 pages, 4 figures. Submitted to ApJ Letters. This letter makes use of the TESS Alert data, which is currently in a beta test phase, using data from the pipelines at the TESS Science Office and at the TESS Science Processing Operations Cente