Estudio de la formación de contaminantes fotoquímicos mediante la modelación matemática y sus efectos en la salud en el Valle de Aburra

IP 1210-13-234-98PONENCIA(S) EN CONGRESO: Numeral investigation of meteorologicalconditions leading to elevated ozone;concentrations in Medellin, Colombia / P. Sahm ... [et al.]. --En: International Conference on Urban Air;Quality and Saturn Workshop (3, 5 : 2001 Mar. 19-23 : Loutraki,Grecia). -- [s.l. : s.n.], 2001. -- p. ; 28;cm. -- Emission inventory in Medellin (Colombia) city : anaproximation /M.V. Toro ... [et al.]. -- En:;contaminantes atmosfericos en la ciudad de Medellin mediante factores de emision Corinar / M. Victoria Toro G.;... [et al.] -- En: Acodal -- Vol. 191 (2002); p. -- ISSN120798 -- Diagnostico de la calidad del aire en el;ancon sur del valle de Aburra / Maria Victoria Toro ... [et al.]'-- en: Contaminacion ambiental. -- Vol. 17,;no. 30-31 (2000); p. 93-103. -- ISSN 01200674.;International Conference on Urban Air Quality and Saturn Workshop (3, 5 :2001 Mar. 19-23 : Loutraki, Grecia).; [s.l. : s.n.], 2001. -- p. ; 28 cm. -- ARTICULO(S) EN REVISTA: Calculode la emision vehicular d

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele