Direct Patterning of Organic Functional Polymers through Conventional Photolithography and Noninvasive Cross-Link Agents

A new technique for direct patterning of functional organic polymers using commercial photolithography setups with a minimal loss of the materials' performances is reported. This result is achieved through novel cross-link agents made by boron- and fluorine-containing heterocycles that can react between themselves upon UV- and white-light exposure

Human β-defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2

There is increasing evidence that innate and adaptive immune responses are intimately linked. This linkage is in part mediated through the recognition of conserved microbial products by Toll-like receptors (TLRs). Detection of microbial products by TLRs can result in induction of inflammatory cytokines and activation of professional antigen-presenting cells, thereby enhancing adaptive immune responses. Here, we show that human β-defensin-3 (hBD-3), an innate antimicrobial peptide, can induce expression of the costimulatory molecules CD80, CD86, and CD40, on monocytes and myeloid dendritic cells in a TLR-dependent manner. Activation of monocytes by hBD-3 is mediated by interaction with TLRs 1 and 2, resulting in signaling that requires myeloid differentiating factor 88 and results in IL-1 receptor-associated kinase-1 phosphorylation. In studies with HEK cells engineered to express various TLRs, we show that activation of NF-κB by hBD-3 depends on the expression of both TLR1 and TLR2. Thus, human TLR signaling is not restricted to recognition of microbial patterns but also can be initiated by host-derived peptides such as hBD-3

Torture and Love: Wives of Chinese Gay Men and Their Cyber Communities

It is estimated that there are at least 14 million women in China who are married to gay men. Called tongqi (同妻) these women often have unknowingly entered into such marriages, with their dreams of a happily family life crushed. For many gay men, these marriages become a useful camouflage that protect them from social pressure and discrimination. While sustaining their heterosexual marriages, they also maintain relationships with gay partners. The women, on the other hand, live tortured lives. They are filled with anger and feel they have been cheated and trapped in their marriages. They are also frightened of the social stigma that they might have contracted HIV from their husbands. With the proliferation of ICTs, especially smartphones, in China, the tongqis are now increasingly afforded the ability to form cybercommunities, which serve as both their social network as well as their political network. This chapter examines the posts and comments of tongqis on open online platforms such as Tianya Luntan and Tongqi Ba. Using this data set, I argue that ICTs, particularly in mobile platforms, allow tongqis to find and build community as well as to educate the public and advocate for social and political change. I also point out, however, the limits of what such technologies can allow tongqis to do, given how laws and societal attitudes about intimate relationships in China have yet to change