Cooling electrons from 1 K to 400 mK with V-based nanorefrigerators

The fabrication and operation of V-based superconducting nanorefrigerators is reported. Specifically, electrons in an Al island are cooled thanks to hot-quasiparticle extraction provided by tunnel-coupled V electrodes. Electronic temperature reduction down to 400 mK starting from 1 K is demonstrated with a cooling power ~20 pW at 1 K for a junction area of 0.3 micron^2. The present architecture extends to higher temperatures refrigeration based on tunneling between superconductors and paves the way to the implementation of a multi-stage on-chip cooling scheme operating from above 1 K down to the mK regime.Comment: 3+ pages, 4 color figure

Knowledge, attitudes, and behavior concerning dental trauma among parents of children attending primary school

BACKGROUND: Traumatic dental injuries occur frequently in children and adolescents. The purpose of the present study is to examine the levels of knowledge and behaviors regarding dental trauma among parents of children attending primary schools in the Apulia region of Italy. METHODS: The study was carried out using an anonymous questionnaire with closed answers distributed to 2,775 parents who were enrolled based on the entire regional school population. Analyses were conducted using the PROC CORRESP (procedure to perform multiple correspondence analysis) and PROC FASTCLUS (procedure to perform cluster analysis). Statistical significance was set at p-value <0.05. RESULTS: A total 15.5% of the sample reported that their children had experienced dental trauma. Overall, 53.8% of respondents stated that they knew what to do in cases of dental injury. Regarding the time limit within which it is possible to usefully intervene for dental trauma, 56.8% of respondents indicated "within 30 minutes". Of the total sample, 56.5% knew how to preserve a displaced tooth. A total 62.9% of parents felt it was appropriate for their children to use dental guards during sports activities. The multivariate analysis showed that wrong knowledge are distributed among all kinds of subject. Parents with previous experience of dental trauma referred right behaviours, instead weak knowledge and wrong behaviours are associated with parents that easily worried for dental events. CONCLUSIONS: This study showed that most parents reported no experience of dental trauma in their children, and half of them did not know what to do in case of traumatic dental injury and they would intervene within 30 minutes, suggesting that dental trauma may trigger panic. However, they did not have the information needed to best assist the affected child. Motivating parents to assume a preventive approach towards dental trauma may produce positive changes that would result an increase of long-term health benefits among both parents and children

Quantification of energy-related parameters for near-fault pulse-like seismic ground motions

An energy-based approach facilitates the explicit consideration of the damage associated with both maximum displacements and cumulative plastic deformations under earthquakes. For structural systems that can undergo pulse-like seismic ground motions close to causative faults, an energy-based approach is deemed especially appropriate with respect to well-established force-or displacement-based strategies. In such a case, in fact, most of the damage is attributable to the dominant pulse-like component, which usually occurs into the velocity time history of the seismic ground motion, thus implying high energy levels imparted to a structural system. In order to enable the implementation of an energy-based approach in the analysis and design of structures under near-fault pulse-like seismic ground motions, this study presents a comprehensive numerical investigation about the influence of seismological parameters and hysteretic behavior on the spectra of the following energy-related parameters: inelastic absolute and relative input energy; input energy reduction factor; hysteretic energy dissipation demand; hysteretic energy reduction factor; dimensionless cumulative plastic deformation ratio. Closed-form approximations are proposed for these spectra, and the numerical values of the corresponding parameters have been also calibrated (with reference to both mean and standard deviation values) as functions of earthquake magnitude, type of hysteretic behavior (i.e., non-degrading or degrading) and ductility level. The outcomes of this study are meant to support the derivation of design spectra for the energy-based seismic design of structures under near-fault pulse-like seismic ground motions

New laboratory predictive tools in deep neck space infections

Introduction. Deep neck space infections (DNSIs) are a group of infective suppurative dis-eases involving deep neck spaces and cervical fascia. Necrotising and septic evolutions are rare, but severe complications can dramatically affect the prognosis and should be promptly managed. Clinical examination often has low sensitivity, although instrumental diagnosis may delay te treatment. We investigated two laboratory tools, LRINEC (Laboratory Risk Indicator for the Necrotizing fasciitis) and NLR (neutrophil to lymphocyte ratio), in the expectation to find a rapidly available predictive indicator that may help in distinguishing necrotising complications and/or systemic septic involvement. Methods. A retrospective observational cohort study was performed on 118 patients who had underwent surgical treatment for DNSIs at our Surgical Unit. LRINEC, NLR and the product LRINEC x NLR were calculated. Results. Statistical analysis showed that these scores may have utility in rapidly predicting the risk of necrotising fasciitis and systemic involvement at an early diagnostic stage. Conclusions. Further studies with a larger cohort may be necessary in order to increase the sensitivity and specificity

Investigation of the Effects of Autorotative Flare Index Variation on Helicopter Flight Dynamics in Autorotation

Autorotation is a flight condition whereby the engine of a helicopter is no longer supplying power to the main rotor system, which is driven solely by the upward flow of the air moving through the rotor. For helicopters, autorotation is a common emergency procedure performed by pilots to safely land the vehicle in the event of a power failure or tail-rotor failure. In the classic analysis of dynamic stability of helicopters in powered flight, it is common practice to neglect the effect of variation of rotor angular velocity, as the rotorspeed is constant. However, this assumption is no longer justified in case of autorotative flight. Therefore, the rotorspeed becomes an additional degree-of-freedom in autorotation, giving rise to a new stability mode that couples with classical rigid-body modes. The present paper aims at understanding the role of the rotorspeed degree-of-freedom in modifying the stability characteristics in autorotation of rotor systems with different autorotative flare indexes. Results show that the helicopter dynamics are considerably affected in autorotation as a consequence of the fact that the rotorspeed degree of freedom couples with the heave subsidence mode. Therefore, autorotation requires a different control strategy by the pilot and should not be mistakenly considered only as an energy management task. Furthermore, the autorotative flare index, used to characterize the autorotative performance during the preliminary design phase of a new helicopter, provides only energy information. Indeed, this paper demonstrates that high values of this index, representative of good autorotative performance in terms of available energy over required energy, may lead to degraded stability characteristics of the helicopter in autorotation.Control & Simulatio

Performance of horn-coupled transition edge sensors for L- and S-band optical detection on the SAFARI instrument

We describe the geometry, architecture, dark- and optical performance of ultra-low-noise transition edge sensors as THz detectors for the SAFARI instrument. The TESs are fabricated from superconducting Mo/Au bilayers coupled to impedance-matched superconducting ß-phase Ta thin-film absorbers. The detectors have phonon-limited dark noise equivalent powers of order 0.5 - 1.0 aW/$\sqrt{Hz}$ and saturation powers of order 20 - 40 fW. The low temperature test configuration incorporating micro-machined backshorts is also described, and construction and typical performance characteristics for the optical load are shown. We report preliminary measurements of the optical performance of these TESs for two SAFARI bands; L-band at 110 - 210 µm and S-band 34 - 60 µm .European Space AgencyThis is the final version of the article. It first appeared from SPIE via http://dx.doi.org/10.1117/12.223274

FEM analysis of RF breast ablation: Multiprobe versus cool-tip electrode

Background: Radio-frequency ablation (RFA) has recently received much attention as an effective minimally invasive strategy for the local treatment of tumors. The purpose of this study was to evaluate the efficacy of single-needle cool-tip RF breast ablation in terms of temperature distribution and duration of the procedure as compared to multiprobe RF breast ablation. Materials and Methods: Two different commercially available radiofrequency ablation needle electrodes were compared. Finite-element method (FEM) models were developed to simulate the thermoablation procedures. A series of ex vivo radiofrequency thermal lesions were induced to check the response of the FEM calculations. Results: Data obtained from FEM models and from ex vivo procedures showed that cool-tip RF breast ablation assures better performances than multiprobe RF breast ablation in terms of temperature distribution and duration of the procedure. Histopathological analysis of the cool-tip RF thermoablated specimens showed successful induction of coagulation necrosis in the thermoablated specimens. Conclusion: Data obtained from FEM models and from ex vivo procedures suggest that the proposed cool-tip RF breast ablation may kill more tumor cells in vivo with a single application than the multiprobe RF breast ablation

Left gaze bias in humans, rhesus monkeys and domestic dogs

While viewing faces, human adults often demonstrate a natural gaze bias towards the left visual field, that is, the right side of the viewee’s face is often inspected first and for longer periods. Using a preferential looking paradigm, we demonstrate that this bias is neither uniquely human nor limited to primates, and provide evidence to help elucidate its biological function within a broader social cognitive framework. We observed that 6-month-old infants showed a wider tendency for left gaze preference towards objects and faces of different species and orientation, while in adults the bias appears only towards upright human faces. Rhesus monkeys showed a left gaze bias towards upright human and monkey faces, but not towards inverted faces. Domestic dogs, however, only demonstrated a left gaze bias towards human faces, but not towards monkey or dog faces, nor to inanimate object images. Our findings suggest that face- and species-sensitive gaze asymmetry is more widespread in the animal kingdom than previously recognised, is not constrained by attentional or scanning bias, and could be shaped by experience to develop adaptive behavioural significance