Influence of Reciprocal links in Social Networks

In this Letter, we empirically study the influence of reciprocal links, in order to understand its role in affecting the structure and function of directed social networks. Experimental results on two representative datesets, Sina Weibo and Douban, demonstrate that the reciprocal links indeed play a more important role than non-reciprocal ones in both spreading information and maintaining the network robustness. In particular, the information spreading process can be significantly enhanced by considering the reciprocal effect. In addition, reciprocal links are largely responsible for the connectivity and efficiency of directed networks. This work may shed some light on the in-depth understanding and application of the reciprocal effect in directed online social networks

2,10-Dibromo-6,6-dimethyl­dibenzo[d,f][1,3]dioxepine

In the crystal structure of the title compound, C15H12Br2O2, which was synthesized from 2,10-dibromo-2,2′-dihydroxy­biphenyl and 2,2-dimethoxy­propane, the aromatic rings are twisted by 35 (1)°. The heterocyclic ring exhibits a twisted conformation

2,10-Dibromo-6-isobutyl-6-methyl­dibenzo[d,f][1,3]dioxepine

In the crystal structure of the title compound, C18H18Br2O2, the two benzene rings of the bridged biphenyl unit are twisted by 38.0 (1)°

3,9-Dibromo-5,7-dihydro­dibenzo[c,e]oxepine

The title compound, C14H10Br2O, is a biphenyl derivative containing a –CH2—O—CH2– bridge in the 2,2′-position. The compound displays a twisted conformation with the two benzene rings making a dihedral angle of 45.02 (5)°, while the central seven-membered ring is in a boat conformation. The mol­ecule lies on a crystallographic twofold axis of symmetry passing through the O atom and bis­ecting the 1,1′ C—C bond

A simulated study on the performance of diesel engine with ethanol-diesel blend fuel

This paper describes the simulated study on atomization, wall-film formation, combustion and emission forming process of ethanol-diesel blend fuels in a high speed light duty diesel engine. The result shows that increased ethanol volume percentage of the blend fuels could improve atomization and reduce wall-film formation. However, in the meanwhile, with the increased ethanol volume percentage, low heat values of blend fuels decrease, while both total heat releases and cylinder pressures drop. By adding codes into the FIRE software, the NOx and soot formation region mass fractions are outputted. The simulated results display a good correlation with the NOx and soot formation. Besides, the NOx, soot and CO emissions decrease with the increased ethanol volume percentage. The power output of engine penalize, while energy utilization of blend fuels improve and combustion noise reduce, owing to the increased ethanol volume percentage

2′,10′-Dibromo­spiro­[cylohexane-1,6-di­benzo[d,f][1,3]dioxepine]

In the title compound, C18H16Br2O2, the dihedral angle between the aromatic rings is 35.55 (17)° and the cyclohexyl ring adopts a chair-like conformation. In the crystal, molecules are linked by van der Waals forces

3,9-Dibromo-6,7-dihydro-5H-dibenzo[c,e]thiepine

In the title mol­ecule, C14H10Br2S, the two benzene rings form a dihedral angle of 48.35 (14)°. The seven-membered ring adopts a boat conformation. In the crystal structure, mol­ecules are related by translation along the b axis and exhibit C—H⋯π inter­actions

Significantly reduced radiation dose to operators during percutaneous vertebroplasty using a new cement delivery device

BACKGROUND: Percutaneous vertebroplasy (PVP) might lead to significant radiation exposure to patients, operators, and operating room personnel. Therefore, radiaton exposure is a concern. The aim of this study was to present a remote control cement delivery device and study whether it can reduce dose exposue to operators. METHODS: After meticulous preoperative preparation, a series of 40 osteoporosis patients were treated with unilateral approach PVP using the new cement delivery divice. We compared levels of fluoroscopic exposure to operator standing on different places during operation. group A: operator stood about 4 meters away from X-ray tube behind the lead sheet. group B: operator stood adjacent to patient as using conventional manual cement delivery device. RESULTS: During whole operation process, radiation dose to the operator (group A) was 0.10 ± 0.03 (0.07-0.15) μSv, group B was 12.09 ± 4.67 (10–20) μSv. a difference that was found to be statistically significant (P < 0.001) between group A and group B. CONCLUSION: New cement delivery device plus meticulous preoperative preparation can significantly decrease radiation dose to operators

MicroRNA-101 Exerts Tumor-Suppressive Functions in Non-small Cell Lung Cancer through Directly Targeting Enhancer of Zeste Homolog 2

Introduction:Overexpression of the enhancer of zeste homolog 2 (EZH2) protein has been found in broad range of cancer types, including non-small cell lung cancer (NSCLC). Nevertheless, the mechanisms by which EZH2 becomes overexpressed in NSCLC remain unclear. MicroRNAs (miRNAs) can regulate target gene expression through translational control. In this study, we investigate whether miRNA (miR-101) regulates EZH2 expression in NSCLC.Methods:We evaluated the expression of miR-101 and EZH2 in 20 matched NSCLC and adjacent nontumor lung tissues by reverse-transcriptase polymerase chain reaction and immunohistochemistry, respectively. Luciferase reporter assay was used to determine whether miR-101 directly targets EZH2. To assess the effect of miR-101 on NSCLC biological behavior, cell proliferation, invasion, and response to chemotherapy were analyzed using NSCLC cells transfected with miR-101 mimics or transfected with specific small interfering RNA to deplete EZH2 (small interfering RNA-EZH2).Results:Reduced expression of miR-101 was associated with overexpression of EZH2 in NSCLC tumor tissues. Transfection of miR-101 mimics significantly suppressed the activity of the luciferase reporter containing wild type but not mutant EZH2 3′-UTR and decreased EZH2 expression in NSCLC cell lines. Furthermore, enforced expression of miR-101 or knockdown of EZH2 led to reduced NSCLC cell proliferation and invasion and sensitized cancer cells to paclitaxel-mediated apoptosis through inducing expression of the proapoptotic protein Bim.Conclusions:miR-101 inhibits cell proliferation and invasion and enhances paclitaxel-induced apoptosis in NSCLC cells, at least in part, by directly repressing EZH2 expression. Therapeutic strategies to rescue miR-101 expression or silence EZH2 may be beneficial to patients with NSCLC in the future