Health-related quality of life in pediatric patients with leukemia in Singapore: a cross-sectional pilot study

There has been a paradigm shift in health service delivery to a more holistic approach, which considers Quality of Life (QoL) and overall functioning. Health-Related Quality of Life (HRQoL) is a multidimensional construct that encompasses physical functioning as well as psychosocial aspects of emotional and social functioning. This study explored factors related to HRQoL in Asian pediatric patients with leukemia in Singapore. The available variables included: age, treatment duration, household income, gender, ethnicity, religion, diagnosis, and phase of treatment. It is hypothesized that the relationships will be significant. In the current study, there were 60 patients (60% males) with leukemia; their ages ranged from 1 to 21 years (Mean = 8.03, Standard Deviation = 4.55). The hypothesis was partially supported. Age had a significant positive relationship with physical functioning, r(60) = 0.28, p < 0.05, physical health, r(60) = 0.28, p < 0.05, and the total HRQoL score, r(60) = 0.29, p < 0.05. Treatment duration had a positive relationship with school functioning, r(60) = 0.28, p < 0.05. All other correlations were statistically non-significant. The effects of the available psychosocial variables of gender, ethnicity, and religion were examined on scores from the Pediatric Quality of Life Inventory (PedsQL). Ethnicity had a significant effect on social functioning, U = 292.00, p < 0.05, r = 0.3 (medium effect size). Specifically, Chinese (Median = 85.00, n = 33) had significantly higher scores on social functioning than others (Median = 70.00, n = 27). The remaining comparisons were statistically non-significant. The current findings added to QoL research, and provided an impetus for more research in the area of HRQoL for children with leukemia in Singapore

Expression of early B cell and NK cell markers in acute megakaryoblastic leukemia

Cancer Research Therapy and Control4131-37CRTC

AB109. Novel constitutional and somatic RB1 mutations underlying retinal cancers in addition to TNFα, KIF13A and MGMT alterations

10.21037/atm.2017.s1095S2AB109-AB10

A "Wait-and-See" Approach to Quiescent Single-System Langerhans Cell Histiocytosis to Spare Children From Chemotherapy

10.3389/fped.2020.00466FRONTIERS IN PEDIATRICS

Parental origin of allelic loss.

<p>Parental origin of allelic loss.</p

Incidence of germline and somatic <i>RB1</i> point mutations in 50 RB cases.

<p>A total of 61 <i>RB1</i> point mutations were identified in 50 RB probands. The distribution of mutations by type of tumor (unilateral and bilateral) and whether they were detected in blood (germline) or only tumor (somatic) is shown.</p

Spectrum of germline <i>RB1</i> point mutations detected in blood of probands.

<p>Spectrum of germline <i>RB1</i> point mutations detected in blood of probands.</p

Distribution of total <i>RB1</i> point mutations by Type.

<p>The frequency of nonsense, frameshift, splice site, missense and promoter mutations among all the point mutations identified in our cohort.</p