Triggered release in lipid bilayer-capped mesoporous silica nanoparticles containing SPION using an alternating magnetic field

[EN] We report here the on-command cargo controlled delivery using an alternating magnetic field (AMF) from magnetic silica mesoporous supports capped with a lipid bilayer. © 2012 The Royal Society of Chemistry.Financial support from the Spanish Government (projects MAT2009-14564-C04-01 and CTQ2008-00690) and the Generalitat Valenciana (project PROMETEO/2009/016) is gratefully acknowledged. E. B. thanks the Spanish Ministry of Education (MEC) for his Jose Castillejo fellowship (JC2010-0090).Bringas, E.; Köysüren, Ö.; Quach, DV.; Mahmoudi, M.; Aznar Gimeno, E.; Roehling, JD.; Marcos Martínez, MD.... (2012). Triggered release in lipid bilayer-capped mesoporous silica nanoparticles containing SPION using an alternating magnetic field. Chemical Communications. 48:5647-5649. https://doi.org/10.1039/C2CC31563GS5647564948Aznar, E., Martínez-Máñez, R., & Sancenón, F. (2009). Controlled release using mesoporous materials containing gate-like scaffoldings. Expert Opinion on Drug Delivery, 6(6), 643-655. doi:10.1517/17425240902895980Cotí, K. K., Belowich, M. E., Liong, M., Ambrogio, M. W., Lau, Y. A., Khatib, H. A., … Stoddart, J. F. (2009). Mechanised nanoparticles for drug delivery. Nanoscale, 1(1), 16. doi:10.1039/b9nr00162jLai, C.-Y., Trewyn, B. G., Jeftinija, D. M., Jeftinija, K., Xu, S., Jeftinija, S., & Lin, V. S.-Y. (2003). A Mesoporous Silica Nanosphere-Based Carrier System with Chemically Removable CdS Nanoparticle Caps for Stimuli-Responsive Controlled Release of Neurotransmitters and Drug Molecules. Journal of the American Chemical Society, 125(15), 4451-4459. doi:10.1021/ja028650lPark, C., Oh, K., Lee, S. C., & Kim, C. (2007). Controlled Release of Guest Molecules from Mesoporous Silica Particles Based on a pH-Responsive Polypseudorotaxane Motif. Angewandte Chemie International Edition, 46(9), 1455-1457. doi:10.1002/anie.200603404Casasús, R., Climent, E., Marcos, M. D., Martínez-Máñez, R., Sancenón, F., Soto, J., … Ruiz, E. (2008). Dual Aperture Control on pH- and Anion-Driven Supramolecular Nanoscopic Hybrid Gate-like Ensembles. Journal of the American Chemical Society, 130(6), 1903-1917. doi:10.1021/ja0756772Liu, R., Liao, P., Liu, J., & Feng, P. (2011). Responsive Polymer-Coated Mesoporous Silica as a pH-Sensitive Nanocarrier for Controlled Release. Langmuir, 27(6), 3095-3099. doi:10.1021/la104973jCliment, E., Martínez-Máñez, R., Sancenón, F., Marcos, M. D., Soto, J., Maquieira, A., & Amorós, P. (2010). Controlled Delivery Using Oligonucleotide-Capped Mesoporous Silica Nanoparticles. Angewandte Chemie International Edition, 49(40), 7281-7283. doi:10.1002/anie.201001847Mal, N. K., Fujiwara, M., & Tanaka, Y. (2003). Photocontrolled reversible release of guest molecules from coumarin-modified mesoporous silica. Nature, 421(6921), 350-353. doi:10.1038/nature01362Aznar, E., Marcos, M. D., Martínez-Máñez, R., Sancenón, F., Soto, J., Amorós, P., & Guillem, C. (2009). pH- and Photo-Switched Release of Guest Molecules from Mesoporous Silica Supports. Journal of the American Chemical Society, 131(19), 6833-6843. doi:10.1021/ja810011pFu, Q., Rao, G. V. R., Ista, L. K., Wu, Y., Andrzejewski, B. P., Sklar, L. A., … López, G. P. (2003). Control of Molecular Transport Through Stimuli-Responsive Ordered Mesoporous Materials. Advanced Materials, 15(15), 1262-1266. doi:10.1002/adma.200305165Thomas, C. R., Ferris, D. P., Lee, J.-H., Choi, E., Cho, M. H., Kim, E. S., … Zink, J. I. (2010). Noninvasive Remote-Controlled Release of Drug Molecules in Vitro Using Magnetic Actuation of Mechanized Nanoparticles. Journal of the American Chemical Society, 132(31), 10623-10625. doi:10.1021/ja1022267Ruiz-Hernández, E., Baeza, A., & Vallet-Regí, M. (2011). Smart Drug Delivery through DNA/Magnetic Nanoparticle Gates. ACS Nano, 5(2), 1259-1266. doi:10.1021/nn1029229Aznar, E., Mondragón, L., Ros-Lis, J. V., Sancenón, F., Marcos, M. D., Martínez-Máñez, R., … Amorós, P. (2011). Finely Tuned Temperature-Controlled Cargo Release Using Paraffin-Capped Mesoporous Silica Nanoparticles. Angewandte Chemie International Edition, 50(47), 11172-11175. doi:10.1002/anie.201102756Bruce, I. J., Taylor, J., Todd, M., Davies, M. J., Borioni, E., Sangregorio, C., & Sen, T. (2004). Synthesis, characterisation and application of silica-magnetite nanocomposites. Journal of Magnetism and Magnetic Materials, 284, 145-160. doi:10.1016/j.jmmm.2004.06.032Sen, T., Magdassi, S., Nizri, G., & Bruce, I. J. (2006). Dispersion of magnetic nanoparticles in suspension. Micro & Nano Letters, 1(1), 39. doi:10.1049/mnl:20065033Zhang, L., Longo, M. L., & Stroeve, P. (2000). Mobile Phospholipid Bilayers Supported on a Polyion/Alkylthiol Layer Pair. Langmuir, 16(11), 5093-5099. doi:10.1021/la9913405Liu, J., Stace-Naughton, A., Jiang, X., & Brinker, C. J. (2009). Porous Nanoparticle Supported Lipid Bilayers (Protocells) as Delivery Vehicles. Journal of the American Chemical Society, 131(4), 1354-1355. doi:10.1021/ja808018yLiu, J., Jiang, X., Ashley, C., & Brinker, C. J. (2009). Electrostatically Mediated Liposome Fusion and Lipid Exchange with a Nanoparticle-Supported Bilayer for Control of Surface Charge, Drug Containment, and Delivery. Journal of the American Chemical Society, 131(22), 7567-7569. doi:10.1021/ja902039yAshley, C. E., Carnes, E. C., Phillips, G. K., Padilla, D., Durfee, P. N., Brown, P. A., … Brinker, C. J. (2011). The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers. Nature Materials, 10(5), 389-397. doi:10.1038/nmat2992Hoare, T., Timko, B. P., Santamaria, J., Goya, G. F., Irusta, S., Lau, S., … Kohane, D. S. (2011). Magnetically Triggered Nanocomposite Membranes: A Versatile Platform for Triggered Drug Release. Nano Letters, 11(3), 1395-1400. doi:10.1021/nl200494tNappini, S., Bonini, M., Bombelli, F. B., Pineider, F., Sangregorio, C., Baglioni, P., & Nordèn, B. (2011). Controlled drug release under a low frequency magnetic field: effect of the citrate coating on magnetoliposomes stability. Soft Matter, 7(3), 1025-1037. doi:10.1039/c0sm00789gMalam, Y., Loizidou, M., & Seifalian, A. M. (2009). Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer. Trends in Pharmacological Sciences, 30(11), 592-599. doi:10.1016/j.tips.2009.08.004Mahmoudi, M., Laurent, S., Shokrgozar, M. A., & Hosseinkhani, M. (2011). Toxicity Evaluations of Superparamagnetic Iron Oxide Nanoparticles: Cell «Vision» versus Physicochemical Properties of Nanoparticles. ACS Nano, 5(9), 7263-7276. doi:10.1021/nn2021088Mahmoudi, M., Azadmanesh, K., Shokrgozar, M. A., Journeay, W. S., & Laurent, S. (2011). Effect of Nanoparticles on the Cell Life Cycle. Chemical Reviews, 111(5), 3407-3432. doi:10.1021/cr100316

Constraints on the χ_(c1) versus χ_(c2) polarizations in proton-proton collisions at √s = 8 TeV

The polarizations of promptly produced χ_(c1) and χ_(c2) mesons are studied using data collected by the CMS experiment at the LHC, in proton-proton collisions at √s=8  TeV. The χ_c states are reconstructed via their radiative decays χ_c → J/ψγ, with the photons being measured through conversions to e⁺e⁻, which allows the two states to be well resolved. The polarizations are measured in the helicity frame, through the analysis of the χ_(c2) to χ_(c1) yield ratio as a function of the polar or azimuthal angle of the positive muon emitted in the J/ψ → μ⁺μ⁻ decay, in three bins of J/ψ transverse momentum. While no differences are seen between the two states in terms of azimuthal decay angle distributions, they are observed to have significantly different polar anisotropies. The measurement favors a scenario where at least one of the two states is strongly polarized along the helicity quantization axis, in agreement with nonrelativistic quantum chromodynamics predictions. This is the first measurement of significantly polarized quarkonia produced at high transverse momentum