Difference of <i>ADTRP</i> mRNA expression between groups with different genotypes of rs7753407, and between early-onset CAD cases and controls.

<p>Levels of <i>ADTRP</i> mRNA expression in leukocytes from 134 randomly selected subjects were measured using real-time qRT-PCR. The average level of it in 61 subjects with the risk genotype AA of rs7753407 was significantly lower than that in 73 subjects with genotype GG or GA (<i>P</i> < 0.01, bars represent mean±S.E.). The average level in 37 early-onset CAD cases was significantly lower than that in 49 controls (<i>P</i> < 0.05, bars represent mean±S.E.).</p

Analysis of allelic association of eight SNPs with CAD.

<p>MAF, minor allele frequency; <i>P</i>_HWE, <i>P</i> values for Hardy-Weinberg equilibrium tests; <i>P</i>_obs, observed <i>P</i> value; <i>P</i>_adj, <i>P</i> value after adjustment for covariates of gender, age, hypertension, diabetes, blood lipid profiles, smoking; OR_obs, observed odds ratio; OR_adj, odds ratio after adjustment for the covariates; CI, confidence interval.</p><p>Analysis of allelic association of eight SNPs with CAD.</p

Analysis of genotypic association of eight SNPs with CAD.

<p><i>P</i>_obs, observed <i>P</i> value; <i>P</i>_adj, <i>P</i> value after adjusted for covariates of gender, age, hypertension, diabetes, blood lipid profiles, smoking; OR_adj, odds ratio after adjustment for the covariates; CI, confidence interval.</p><p>Analysis of genotypic association of eight SNPs with CAD.</p

Overview of LD structure among eight SNPs.

<p>A was constructed based on the genotype data of all the subjects in this work, B was constructed based on the genotype data of subjects excluding late-onset CAD patients. D’ was signed with a number in a diamond. Red diamond without a number refers to D’ = 100. F refers to exon 1, L refers to the last exon. Arrow refers to the transcription direction of <i>ADTRP</i>.</p

Clinical and biochemical characteristics of the study subjects.

<p>^aAge at the first diagnosis for CAD and age at the time of enrollment for control. T2DM, type 2 diabetes mellitus; Tch, total cholesterol; TG, triglyceride; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol.</p><p>Clinical and biochemical characteristics of the study subjects.</p