Alzheimer’s Disease and Rheumatoid Arthritis: A Mendelian Randomization Study

Alzheimer’s disease (AD) is the most common neurodegenerative disease. In recent years, multiple pathway analyses of AD genome-wide association studies (GWAS) have been conducted, and provided strong support for immune pathways in AD. Rheumatoid arthritis (RA) is a chronic autoimmune disease. It is reported that antirheumatic drugs had protective effect on dementia in RA patients. However, observational studies have reported a controversial inverse relationship between AD and RA. In addition, Mendelian randomization studies have also been performed to evaluate the association of RA with AD. However, these studies reported inconsistent association of RA with AD. Until now, it is still unclear that AD is a causally associated with RA. Here, we performed a Mendelian randomization study to investigate the causal association of AD with RA. We analyzed the large-scale AD GWAS dataset (74,046 individuals) and RA GWAS dataset (58,284 individuals) from the European descent. However, we did not identify any significant association of AD with RA using inverse-variance weighted meta-analysis (IVW), weighted median regression and MR-Egger regression

Survey on data analysis in social media: A practical application aspect

© 2018 Tsinghua University Press. Social media has more than three billion users sharing events, comments, and feelings throughout the world. It serves as a critical information source with large volumes, high velocity, and a wide variety of data. The previous studies on information spreading, relationship analyzing, and individual modeling, etc., have been heavily conducted to explore the tremendous social and commercial values of social media data. This survey studies the previous literature and the existing applications from a practical perspective. We outline a commonly used pipeline in building social media-based applications and focus on discussing available analysis techniques, such as topic analysis, time series analysis, sentiment analysis, and network analysis. After that, we present the impacts of such applications in three different areas, including disaster management, healthcare, and business. Finally, we list existing challenges and suggest promising future research directions in terms of data privacy, 5G wireless network, and multilingual support

Research on a Variable-Leakage-Flux Permanent Magnet Motor Control System Based on an Adaptive Tracking Estimator

Due to the characteristics of inductance parameter mismatch and back electromotive force harmonics caused by novel leakage flux branches and other non-ideal factors for the variable-leakage-flux permanent magnet (VLF-PM) motor, its control system suffers from a deteriorated performance of the rotor position estimation. To overcome the problems mentioned above, an adaptive tracking estimator of the rotor position is proposed in this paper for the VLF-PM motor control system. First, the proposed method simplifies the VLF-PM motor mathematical model and reduces the effect of inductance parameter variations according to the active flux concept. Then, robust and gradient descent algorithms are utilized to maintain the robustness of inductance parameter variations and eliminate the specific order harmonics owing to the novel leakage flux branches. Meanwhile, the accuracy and stability are enhanced. Furthermore, the position compensation based on the current adaptive tracking strategy is proposed to compensate the rotor position error caused by other non-ideal factors. Finally, the feasibility of the proposed estimated system is verified

Fracture properties and response surface methodology model of alkali-slag concrete under freeze-thaw cycles.pdf

<p>In this paper, response surface methodology is used to study alkali-slag concrete(ASC) fracture toughness; the influence on fracture toughness from high to low is slag content, age and sol ratio, the interaction of slag content and age is the most significant; initiation fracture toughness is about 50%~70% of unstable fracture toughness, crack initiation should be the warning indicator of ASC structure; fracture toughness decreases with freeze-thaw times increasing, its declining rate and degree increase with sol ratio and slag content; increase of sol ratio reduces internal density and hinders depolymerization. Cementitious material content reduces ASC toughness.</p

Bias Evaluation of the Accuracy of Two Extraoral Scanners and an Intraoral Scanner Based on ADA Standards

The spread and application of computer-aided design/computer-aided manufacturing (CAD/CAM) technology have contributed to the rapid development of digitalization in dentistry. The accuracy of scan results is closely related to the devising subsequent treatment plans and outcomes. Professional standards for evaluating scanners are specified in the American National Standard/American Dental Association Standard 132 (ANSI/ADA No. 132). The aims of this study were to use the three samples mentioned in ANSI/ADA No. 132 and evaluate the accuracy and reproducibility of two extraoral scanners and an intraoral scanner based on the inspection standards recommended by ANSI/ADA No. 132. In this study, two trained operators used two extraoral scanners (E4, 3Shape, Denmark & SHINING DS100+, Shining, China) and an intraoral scanner (TRIOS SERIES3, 3Shape, Denmark) to perform 30 scans of each of the three samples at a temperature of 25±2°C and export standard tessellation language files and used reverse engineering software to perform measurements and iterative nearest point matching experiments. The measured values obtained were compared with the reference values measured by a coordinate measuring machine (NC8107, Leader Metrology, USA). We performed a normal distribution test (Shapiro-Wilk test), the nonparametric Kruskal-Wallis test, and an independent-samples t-test to analyze the reproducibility of each scan for different models. The experimental results indicate that the trueness and precision of the two extraoral scanners and the intraoral scanner had a slight mean deviation. The trueness and precision of the three scanners on the curved surface and groove areas are poor. The accuracy and reproducibility of E4 outperformed SHINING and TRIOS. The iterative closest point matching experiment also showed good matching results. The two extraoral scanners and the intraoral scanner in this study can meet the basic clinical requirements in terms of accuracy, and we hope that digital technology will be more widely used in dentistry in the future