Genetic Analysis in UK Biobank Links Insulin Resistance and Transendothelial Migration Pathways to Coronary Artery Disease

UK Biobank is among the world’s largest repositories for phenotypic and genotypic information in individuals of European ancestry1. We performed a genome-wide association study in UK Biobank testing ~9 million DNA sequence variants for association with coronary artery disease (4,831 cases; 115,455 controls) and carried out meta-analysis with previously published results. We identified fifteen novel loci, bringing the total number of coronary artery disease-associated loci to 95. Phenome-wide association scanning revealed that CCDC92 likely affects coronary artery disease through insulin resistance pathways whereas experimental analysis suggests that ARHGEF26 impacts the transendothelial migration of leukocytes

Global nighttime atomic oxygen abundances from GOMOS hydroxyl airglow measurements in the mesopause region

This paper presents a new dataset of nighttime atomic oxygen density [O], derived from OH(8–4) ro-vibrational band emissions, using a non-local thermal equilibrium model, with the aim of offering new insight into the atomic oxygen abundances in the mesopause region. The dataset is derived from the level-1 atmospheric background measurements observed by the Global Ozone Monitoring by Occultation of Stars (GOMOS) instrument aboard Envisat, with the Sounding of the Atmosphere using Broadband Emission Radiometry (SABER) measurements for the atmospheric background. Raw data are reprocessed into monthly zonal mean values in 10∘ latitude bins with a fixed altitude grid of 3 km. The dataset spans from 70∘ S to 70∘ N in latitude and from 80 to 100 km in altitude, covering a time period from May 2002 to December 2011 at local times from 22:00 to 00:00 LT.The atomic oxygen density peaks at about 95 km and the highest values are in the range of 3–8 × 1011 atoms cm−3, depending on latitude and season. There is a rapid decrease of [O] below the peak. The annual oscillation (AO), semiannual oscillation (SAO) and the solar cycle impact are distinguished from the [O] longtime series variations. This new GOMOS [O] dataset conforms to other published datasets and is consistent with the [O] datasets obtained from the Scanning Imaging Absorption Spectrometer for Atmospheric CHartographY (SCIAMACHY) OH airglow measurements within about ±20 %

A comparison of OH nightglow volume emission rates as measured by SCIAMACHY and SABER

Hydroxyl (OH) short-wave infrared emissions arising from OH(4-2, 5-2, 8-5, 9-6) as measured by channel 6 of the SCanning Imaging Absorption spectroMeter for Atmospheric CHartographY (SCIAMACHY) are used to derive concentrations of OH(v=4, 5, 8, and 9) between 80 and 96 km. Retrieved concentrations are used to simulate OH(5-3, 4-2) integrated radiances at 1.6 µm and OH(9-7, 8-6) at 2.0 µm as measured by the Sounding of the Atmosphere using Broadband Emission Radiometry (SABER) instrument, which are not fully covered by the spectral range of SCIAMACHY measurements. On average, SABER “unfiltered” data are on the order of 40 % at 1.6 µm and 20 % at 2.0 µm larger than the simulations using SCIAMACHY data. “Unfiltered” SABER data are a product, which accounts for the shape, width, and transmission of the instrument's broadband filters, which do not cover the full ro-vibrational bands of the corresponding OH transitions. It is found that the discrepancy between SCIAMACHY and SABER data can be reduced by up to 50 %, if the filtering process is carried out manually using published SABER interference filter characteristics and the latest Einstein coefficients from the HITRAN database. Remaining differences are discussed with regard to model parameter uncertainties and radiometric calibration

Modeling and correction of fringe patterns in Doppler asymmetric spatial heterodyne interferometry

Doppler asymmetric spatial heterodyne (DASH) interferometry is a novel concept for observing atmospheric winds. This paper discusses a numerical model for the simulation of fringe patterns and a methodology to correct fringe images for extracting Doppler information from ground-based DASH measurements. Based on the propagation of optical waves, the fringe pattern was modeled considering different angular deviations and optical aberrations. A dislocation between two gratings can introduce an additional spatial modulation associated with the diffraction order, which was seen in laboratory measurements. A phase correction is proposed to remove phase differences between different row interferograms, which is the premise for calculating the average interferogram to improve the signal-to-noise ratio. Laboratory tests, simulation results, and Doppler velocity measurements indicate that a matrix determined in the laboratory can be applied to correct interferograms obtained from ground-based DASH measurements

On the assembly and calibration of a spatial heterodyne interferometer for limb sounding of the middle atmosphere

Spatial heterodyne interferometers are an enabling technology to build highly miniaturized optical instruments for the observation of faint emissions in the atmosphere. They are particularly suited for the deployment on nano- or micro-satellite constellations. One application of the SHI technology is a middle atmosphere temperature sounder based on the measurement of relative intensities emitted by the O2 atmospheric band system. Beside basic design considerations, aspects of the opto-mechanical design and assembly of a monolithic SHI for a space application are addressed. For the characterization of such an instrument, a light stimulus based on a Köhler illuminator is presented